Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers

Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers

Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components. We have already published highly significant associa...

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Bibliographic Details
Main Authors: Andrzej Wiśniewski, Maciej Sobczyński, Konrad Pawełczyk, Irena Porębska, Monika Jasek, Marta Wagner, Wanda Niepiekło-Miniewska, Aneta Kowal, Joanna Dubis, Natalia Jędruchniewicz, Piotr Kuśnierczyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
non-small cell lung cancer
smokers versus never-smokers
antigen-processing machinery
genetics
ERAP1
ERAP2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.664474/full

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