β-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in piglets
Objective Weaning is an important stage in the life of young mammals, which is associated with intestinal inflammation, gut microbiota disorders, and even death. β-Carotene displays anti-inflammatory and antioxidant activities, which can prevent the development of inflammatory diseases. However, whe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Asian-Australasian Association of Animal Production Societies
2021-07-01
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| Series: | Animal Bioscience |
| Subjects: | |
| Online Access: | http://www.animbiosci.org/upload/pdf/ajas-19-0499.pdf |
| _version_ | 1818656259320053760 |
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| author | Ruonan Li Lingqian Li Pan Hong Wuying Lang Junnan Hui Yu Yang Xin Zheng |
| author_facet | Ruonan Li Lingqian Li Pan Hong Wuying Lang Junnan Hui Yu Yang Xin Zheng |
| author_sort | Ruonan Li |
| collection | DOAJ |
| description | Objective Weaning is an important stage in the life of young mammals, which is associated with intestinal inflammation, gut microbiota disorders, and even death. β-Carotene displays anti-inflammatory and antioxidant activities, which can prevent the development of inflammatory diseases. However, whether β-carotene can affect intestinal microbiota remains unclear. Methods Twenty-four piglets were distributed into four groups: the normal suckling group (Con), the weaning group (WG), the weaning+β-carotene (40 mg/kg) group (LCBC), and the weaning+β-carotene (80 mg/kg) group (HCBC). The serum, jejunum, colon, and faeces were collected separately from each group. The effects of β-carotene on the phenotype, overall structure, and composition of gut microbiota were assessed in weaning piglets. Results The results showed that β-carotene improved the growth performance, intestinal morphology and relieved inflammation. Furthermore, β-carotene significantly decreased the species from phyla Bacteroidetes and the genus Prevotella, and Blautia, and increased the species from the phyla Firmicutes and the genera p-75-a5, and Parabacteroides compared to the WG group. Spearman’s correlation analysis showed that Prevotella and Blautia were positively correlated, and Parabacteroides and Synergistes were negatively correlated with the levels of interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-α (TNF-α), while p-75-a5 showed negative correlation with IL-6 in serum samples from piglets. Conclusion These findings indicate that β-carotene could alleviate weaning-induced intestinal inflammation by modulating gut microbiota in piglets. Prevotella may be a potential target of β-carotene in alleviating the weaning-induced intestinal inflammation in piglets. |
| first_indexed | 2024-12-17T03:22:44Z |
| format | Article |
| id | doaj.art-191997bb390b4eada53664531a9a586e |
| institution | Directory Open Access Journal |
| issn | 2765-0189 2765-0235 |
| language | English |
| last_indexed | 2024-12-17T03:22:44Z |
| publishDate | 2021-07-01 |
| publisher | Asian-Australasian Association of Animal Production Societies |
| record_format | Article |
| series | Animal Bioscience |
| spelling | doaj.art-191997bb390b4eada53664531a9a586e2022-12-21T22:05:28ZengAsian-Australasian Association of Animal Production SocietiesAnimal Bioscience2765-01892765-02352021-07-013471221123410.5713/ajas.19.049924446β-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in pigletsRuonan Li0Lingqian Li1Pan Hong2Wuying Lang3Junnan Hui4Yu Yang5Xin Zheng6 College of Animal Science and Technology, Jilin Agricultural University, Changchun 2888, China College of Animal Science and Technology, Jilin Agricultural University, Changchun 2888, China College of Animal Science and Technology, Jilin Agricultural University, Changchun 2888, China College of Animal Science and Technology, Jilin Agricultural University, Changchun 2888, China College of Animal Science and Technology, Jilin Agricultural University, Changchun 2888, China College of Animal Science and Technology, Jilin Agricultural University, Changchun 2888, China College of Animal Science and Technology, Jilin Agricultural University, Changchun 2888, ChinaObjective Weaning is an important stage in the life of young mammals, which is associated with intestinal inflammation, gut microbiota disorders, and even death. β-Carotene displays anti-inflammatory and antioxidant activities, which can prevent the development of inflammatory diseases. However, whether β-carotene can affect intestinal microbiota remains unclear. Methods Twenty-four piglets were distributed into four groups: the normal suckling group (Con), the weaning group (WG), the weaning+β-carotene (40 mg/kg) group (LCBC), and the weaning+β-carotene (80 mg/kg) group (HCBC). The serum, jejunum, colon, and faeces were collected separately from each group. The effects of β-carotene on the phenotype, overall structure, and composition of gut microbiota were assessed in weaning piglets. Results The results showed that β-carotene improved the growth performance, intestinal morphology and relieved inflammation. Furthermore, β-carotene significantly decreased the species from phyla Bacteroidetes and the genus Prevotella, and Blautia, and increased the species from the phyla Firmicutes and the genera p-75-a5, and Parabacteroides compared to the WG group. Spearman’s correlation analysis showed that Prevotella and Blautia were positively correlated, and Parabacteroides and Synergistes were negatively correlated with the levels of interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-α (TNF-α), while p-75-a5 showed negative correlation with IL-6 in serum samples from piglets. Conclusion These findings indicate that β-carotene could alleviate weaning-induced intestinal inflammation by modulating gut microbiota in piglets. Prevotella may be a potential target of β-carotene in alleviating the weaning-induced intestinal inflammation in piglets.http://www.animbiosci.org/upload/pdf/ajas-19-0499.pdfβ-caroteneweaninginflammationgut microbiota |
| spellingShingle | Ruonan Li Lingqian Li Pan Hong Wuying Lang Junnan Hui Yu Yang Xin Zheng β-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in piglets Animal Bioscience β-carotene weaning inflammation gut microbiota |
| title | β-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in piglets |
| title_full | β-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in piglets |
| title_fullStr | β-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in piglets |
| title_full_unstemmed | β-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in piglets |
| title_short | β-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in piglets |
| title_sort | β carotene prevents weaning induced intestinal inflammation by modulating gut microbiota in piglets |
| topic | β-carotene weaning inflammation gut microbiota |
| url | http://www.animbiosci.org/upload/pdf/ajas-19-0499.pdf |
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