Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides
Cystine-stabilized peptides represent a large family of peptides characterized by high structural stability and bactericidal, fungicidal, or insecticidal properties. Found throughout a wide range of taxa, this broad and functionally important family can be subclassified into distinct groups dependen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-06-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/10/6/251 |
| _version_ | 1811186337491976192 |
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| author | S M Ashiqul Islam Christopher Michel Kearney Erich Baker |
| author_facet | S M Ashiqul Islam Christopher Michel Kearney Erich Baker |
| author_sort | S M Ashiqul Islam |
| collection | DOAJ |
| description | Cystine-stabilized peptides represent a large family of peptides characterized by high structural stability and bactericidal, fungicidal, or insecticidal properties. Found throughout a wide range of taxa, this broad and functionally important family can be subclassified into distinct groups dependent upon their number and type of cystine bonding patters, tertiary structures, and/or their species of origin. Furthermore, the annotation of proteins related to the cystine-stabilized family are under-represented in the literature due to their difficulty of isolation and identification. As a result, there are several recent attempts to collate them into data resources and build analytic tools for their dynamic prediction. Ultimately, the identification and delivery of new members of this family will lead to their growing inclusion into the repertoire of commercial viable alternatives to antibiotics and environmentally safe insecticides. This review of the literature and current state of cystine-stabilized peptide biology is aimed to better describe peptide subfamilies, identify databases and analytics resources associated with specific cystine-stabilized peptides, and highlight their current commercial success. |
| first_indexed | 2024-04-11T13:44:44Z |
| format | Article |
| id | doaj.art-191a0e93ca6f40329ff1bb7fcbffb1ea |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T13:44:44Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-191a0e93ca6f40329ff1bb7fcbffb1ea2022-12-22T04:21:08ZengMDPI AGToxins2072-66512018-06-0110625110.3390/toxins10060251toxins10060251Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized PeptidesS M Ashiqul Islam0Christopher Michel Kearney1Erich Baker2Institute of Biomedical Studies, Baylor University, Waco, TX 76798, USADepartment of Biology, Baylor University, Waco, TX 76798, USAInstitute of Biomedical Studies, Baylor University, Waco, TX 76798, USACystine-stabilized peptides represent a large family of peptides characterized by high structural stability and bactericidal, fungicidal, or insecticidal properties. Found throughout a wide range of taxa, this broad and functionally important family can be subclassified into distinct groups dependent upon their number and type of cystine bonding patters, tertiary structures, and/or their species of origin. Furthermore, the annotation of proteins related to the cystine-stabilized family are under-represented in the literature due to their difficulty of isolation and identification. As a result, there are several recent attempts to collate them into data resources and build analytic tools for their dynamic prediction. Ultimately, the identification and delivery of new members of this family will lead to their growing inclusion into the repertoire of commercial viable alternatives to antibiotics and environmentally safe insecticides. This review of the literature and current state of cystine-stabilized peptide biology is aimed to better describe peptide subfamilies, identify databases and analytics resources associated with specific cystine-stabilized peptides, and highlight their current commercial success.http://www.mdpi.com/2072-6651/10/6/251cystine-stabilized peptidesdatabasesprediction toolsknottinscyclotidesSTPsNTPs |
| spellingShingle | S M Ashiqul Islam Christopher Michel Kearney Erich Baker Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides Toxins cystine-stabilized peptides databases prediction tools knottins cyclotides STPs NTPs |
| title | Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides |
| title_full | Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides |
| title_fullStr | Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides |
| title_full_unstemmed | Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides |
| title_short | Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides |
| title_sort | classes databases and prediction methods of pharmaceutically and commercially important cystine stabilized peptides |
| topic | cystine-stabilized peptides databases prediction tools knottins cyclotides STPs NTPs |
| url | http://www.mdpi.com/2072-6651/10/6/251 |
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