Mitochondrial Impairment in Sarcopenia
Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/1/31 |
| _version_ | 1827698248875245568 |
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| author | Francesco Bellanti Aurelio Lo Buglio Gianluigi Vendemiale |
| author_facet | Francesco Bellanti Aurelio Lo Buglio Gianluigi Vendemiale |
| author_sort | Francesco Bellanti |
| collection | DOAJ |
| description | Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting in loss of muscle mass and function. Thus, mitochondrial dysfunction contributes significantly to the complex pathogenesis of sarcopenia, and mitochondria are indicated as potential targets to prevent and treat this age-related condition. After a concise presentation of the age-related modifications in skeletal muscle quality and mitochondrial homeostasis, the present review summarizes the most relevant findings related to mitochondrial alterations in sarcopenia. |
| first_indexed | 2024-03-10T13:26:46Z |
| format | Article |
| id | doaj.art-191a4ee4e57e40f7ac89eecbe02d30a5 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T13:26:46Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-191a4ee4e57e40f7ac89eecbe02d30a52023-11-21T08:43:12ZengMDPI AGBiology2079-77372021-01-011013110.3390/biology10010031Mitochondrial Impairment in SarcopeniaFrancesco Bellanti0Aurelio Lo Buglio1Gianluigi Vendemiale2Department of Medical and Surgical Sciences, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDepartment of Medical and Surgical Sciences, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDepartment of Medical and Surgical Sciences, University of Foggia, viale Pinto 1, 71122 Foggia, ItalySarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting in loss of muscle mass and function. Thus, mitochondrial dysfunction contributes significantly to the complex pathogenesis of sarcopenia, and mitochondria are indicated as potential targets to prevent and treat this age-related condition. After a concise presentation of the age-related modifications in skeletal muscle quality and mitochondrial homeostasis, the present review summarizes the most relevant findings related to mitochondrial alterations in sarcopenia.https://www.mdpi.com/2079-7737/10/1/31protein homeostasisaging skeletal musclemitochondrial dysfunction |
| spellingShingle | Francesco Bellanti Aurelio Lo Buglio Gianluigi Vendemiale Mitochondrial Impairment in Sarcopenia Biology protein homeostasis aging skeletal muscle mitochondrial dysfunction |
| title | Mitochondrial Impairment in Sarcopenia |
| title_full | Mitochondrial Impairment in Sarcopenia |
| title_fullStr | Mitochondrial Impairment in Sarcopenia |
| title_full_unstemmed | Mitochondrial Impairment in Sarcopenia |
| title_short | Mitochondrial Impairment in Sarcopenia |
| title_sort | mitochondrial impairment in sarcopenia |
| topic | protein homeostasis aging skeletal muscle mitochondrial dysfunction |
| url | https://www.mdpi.com/2079-7737/10/1/31 |
| work_keys_str_mv | AT francescobellanti mitochondrialimpairmentinsarcopenia AT aureliolobuglio mitochondrialimpairmentinsarcopenia AT gianluigivendemiale mitochondrialimpairmentinsarcopenia |