The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE?
OBJECTIVE: To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM). METHODS: 146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to t...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-04-01
|
| Series: | Translational Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523317303790 |
| _version_ | 1818515484532801536 |
|---|---|
| author | Chao You Anna K. Kaiser Pascal Baltzer Julia Krammer Yajia Gu Weijun Peng Stefan O. Schönberg Clemens G. Kaiser |
| author_facet | Chao You Anna K. Kaiser Pascal Baltzer Julia Krammer Yajia Gu Weijun Peng Stefan O. Schönberg Clemens G. Kaiser |
| author_sort | Chao You |
| collection | DOAJ |
| description | OBJECTIVE: To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM). METHODS: 146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to the high-risk cases on the basis of age. The correlation of BPE with factors such as fibroglandular tissue (FGT), age, menopausal status, breast cancer, high-risk precondition as well as motion were investigated using linear regression. RESULTS: BPE positively correlated with FGT (P < .001) and negatively correlated with menopausal status (P < .001). Cancer did not show an effect on BPE (P > .05). A high-risk precondition showed a significant impact on the formation of BPE (P < .05). However, when corrected for motion, the correlation between BPE and a high-risk precondition became weak and insignificant, and a highly significant association between BPE and motion was revealed (P < .01). CONCLUSION: BPE positively correlated with FGT and negatively correlated with age. Cancer did not have an effect on BPE. A high-risk precondition appears to have a negative effect on BPE. However, when corrected for motion, high-risk preconditions became insignificant. Technical as well as physiological influences seem to play an important role in the formation of BPE. |
| first_indexed | 2024-12-11T00:29:27Z |
| format | Article |
| id | doaj.art-191ae2a61cf24d26984e402ca822a811 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-11T00:29:27Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-191ae2a61cf24d26984e402ca822a8112022-12-22T01:27:24ZengElsevierTranslational Oncology1936-52332018-04-01112243249The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE?Chao You0Anna K. Kaiser1Pascal Baltzer2Julia Krammer3Yajia Gu4Weijun Peng5Stefan O. Schönberg6Clemens G. Kaiser7Department of Radiology, Fudan University Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversitySchool of Social Science, University of MannheimDepartment of Neuroradiology, Friedrich-Alexander-University Hospital Erlangen-NürnbergInstitute of Clinical Radiology and Nuclear Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim-University of HeidelbergDepartment of Radiology, Fudan University Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Radiology, Fudan University Cancer Center, Department of Oncology, Shanghai Medical College, Fudan UniversityInstitute of Clinical Radiology and Nuclear Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim-University of HeidelbergInstitute of Clinical Radiology and Nuclear Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim-University of Heidelberg; Address all correspondence to: Clemens G. Kaiser, M.D., University Medical Centre Mannheim, Medical Faculty Mannheim - University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.OBJECTIVE: To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM). METHODS: 146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to the high-risk cases on the basis of age. The correlation of BPE with factors such as fibroglandular tissue (FGT), age, menopausal status, breast cancer, high-risk precondition as well as motion were investigated using linear regression. RESULTS: BPE positively correlated with FGT (P < .001) and negatively correlated with menopausal status (P < .001). Cancer did not show an effect on BPE (P > .05). A high-risk precondition showed a significant impact on the formation of BPE (P < .05). However, when corrected for motion, the correlation between BPE and a high-risk precondition became weak and insignificant, and a highly significant association between BPE and motion was revealed (P < .01). CONCLUSION: BPE positively correlated with FGT and negatively correlated with age. Cancer did not have an effect on BPE. A high-risk precondition appears to have a negative effect on BPE. However, when corrected for motion, high-risk preconditions became insignificant. Technical as well as physiological influences seem to play an important role in the formation of BPE.http://www.sciencedirect.com/science/article/pii/S1936523317303790 |
| spellingShingle | Chao You Anna K. Kaiser Pascal Baltzer Julia Krammer Yajia Gu Weijun Peng Stefan O. Schönberg Clemens G. Kaiser The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE? Translational Oncology |
| title | The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE? |
| title_full | The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE? |
| title_fullStr | The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE? |
| title_full_unstemmed | The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE? |
| title_short | The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE? |
| title_sort | assessment of background parenchymal enhancement bpe in a high risk population what causes bpe |
| url | http://www.sciencedirect.com/science/article/pii/S1936523317303790 |
| work_keys_str_mv | AT chaoyou theassessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT annakkaiser theassessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT pascalbaltzer theassessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT juliakrammer theassessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT yajiagu theassessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT weijunpeng theassessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT stefanoschonberg theassessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT clemensgkaiser theassessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT chaoyou assessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT annakkaiser assessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT pascalbaltzer assessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT juliakrammer assessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT yajiagu assessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT weijunpeng assessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT stefanoschonberg assessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe AT clemensgkaiser assessmentofbackgroundparenchymalenhancementbpeinahighriskpopulationwhatcausesbpe |