Vascular Calcification in Diabetic Kidney Disease
The pathogenesis of vascular calcification (VC) in diabetes mellitus (DM) has not been completely elucidated. VC often occur in patients with DM and chronic kidney disease (CKD). The incidence of VC in diabetic patients is more frequent than in nondiabetic patients, which is an important cause of ca...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Kidney and Dialysis |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-8236/2/4/54 |
| _version_ | 1797456770721906688 |
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| author | Olivier Phan Nobuhiko Joki |
| author_facet | Olivier Phan Nobuhiko Joki |
| author_sort | Olivier Phan |
| collection | DOAJ |
| description | The pathogenesis of vascular calcification (VC) in diabetes mellitus (DM) has not been completely elucidated. VC often occur in patients with DM and chronic kidney disease (CKD). The incidence of VC in diabetic patients is more frequent than in nondiabetic patients, which is an important cause of cardiovascular (CV) morbidity and mortality. VC is a progressive transformation of the vascular wall; it results from an active and complex phenomenon affecting particularly the vascular smooth muscle cells (VSMCs). It leads to a change in the phenotype of the VSMCs towards an osteoblastic-like phenotype. DM is associated with specific risk factors in addition to hyperglycemia, such as increased oxidative stress, proinflammatory state, hypertension, and chronic kidney disease (CKD) promoting endothelial dysfunction. This article provides an overview and update of the pathophysiological data on the role of DM in VC progression. |
| first_indexed | 2024-03-09T16:12:38Z |
| format | Article |
| id | doaj.art-191b9eb370a54c23b816e77e6c1cade6 |
| institution | Directory Open Access Journal |
| issn | 2673-8236 |
| language | English |
| last_indexed | 2024-03-09T16:12:38Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Kidney and Dialysis |
| spelling | doaj.art-191b9eb370a54c23b816e77e6c1cade62023-11-24T16:05:09ZengMDPI AGKidney and Dialysis2673-82362022-12-012459560610.3390/kidneydial2040054Vascular Calcification in Diabetic Kidney DiseaseOlivier Phan0Nobuhiko Joki1Service of Nephrology and Hypertension, University Hospital of Lausanne, 1011 Lausanne, SwitzerlandDivision of Nephrology, TOHO University Ohashi Medical Center, Tokyo 153-8515, JapanThe pathogenesis of vascular calcification (VC) in diabetes mellitus (DM) has not been completely elucidated. VC often occur in patients with DM and chronic kidney disease (CKD). The incidence of VC in diabetic patients is more frequent than in nondiabetic patients, which is an important cause of cardiovascular (CV) morbidity and mortality. VC is a progressive transformation of the vascular wall; it results from an active and complex phenomenon affecting particularly the vascular smooth muscle cells (VSMCs). It leads to a change in the phenotype of the VSMCs towards an osteoblastic-like phenotype. DM is associated with specific risk factors in addition to hyperglycemia, such as increased oxidative stress, proinflammatory state, hypertension, and chronic kidney disease (CKD) promoting endothelial dysfunction. This article provides an overview and update of the pathophysiological data on the role of DM in VC progression.https://www.mdpi.com/2673-8236/2/4/54vascular calcificationdiabeteschronic kidney disease |
| spellingShingle | Olivier Phan Nobuhiko Joki Vascular Calcification in Diabetic Kidney Disease Kidney and Dialysis vascular calcification diabetes chronic kidney disease |
| title | Vascular Calcification in Diabetic Kidney Disease |
| title_full | Vascular Calcification in Diabetic Kidney Disease |
| title_fullStr | Vascular Calcification in Diabetic Kidney Disease |
| title_full_unstemmed | Vascular Calcification in Diabetic Kidney Disease |
| title_short | Vascular Calcification in Diabetic Kidney Disease |
| title_sort | vascular calcification in diabetic kidney disease |
| topic | vascular calcification diabetes chronic kidney disease |
| url | https://www.mdpi.com/2673-8236/2/4/54 |
| work_keys_str_mv | AT olivierphan vascularcalcificationindiabetickidneydisease AT nobuhikojoki vascularcalcificationindiabetickidneydisease |