Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration
Engineered electrospun membranes have emerged as promising materials in guided tissue regeneration, as they provide an appropriate framework for the formation of new functional periodontal tissues. The development of multifunctional local drug delivery systems with sustained release of drugs for pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/5/850 |
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| author | Georgia K. Pouroutzidou Maria Lazaridou Chrysanthi Papoulia Ioannis Tsamesidis Konstantinos Chrissafis George Vourlias Konstantinos M. Paraskevopoulos Dimitrios Bikiaris Eleana Kontonasaki |
| author_facet | Georgia K. Pouroutzidou Maria Lazaridou Chrysanthi Papoulia Ioannis Tsamesidis Konstantinos Chrissafis George Vourlias Konstantinos M. Paraskevopoulos Dimitrios Bikiaris Eleana Kontonasaki |
| author_sort | Georgia K. Pouroutzidou |
| collection | DOAJ |
| description | Engineered electrospun membranes have emerged as promising materials in guided tissue regeneration, as they provide an appropriate framework for the formation of new functional periodontal tissues. The development of multifunctional local drug delivery systems with sustained release of drugs for prolonged infection control can be used in periodontal surgical interventions to simultaneously prohibit epithelium downgrowth and ensure proper healing and regeneration of damaged periodontal tissues. The aim of the present study was the fabrication of novel composite membranes from PLGA/moxifloxacin-loaded mesoporous nanocarriers through electrospinning and the evaluation of their drug release profiles. The addition of moxifloxacin-loaded mesoporous nanocarriers in PLGA yielded a sustained and prolonged drug release, while maintaining satisfactory mechanical strength. The freshly fabricated membranes were found to be biocompatible at masses less than 1 mg after exposure to healthy erythrocytes. Increase in the amount of polymer led to more uniform fibers with large diameters and pores. The study of the parameters of the electrospinning process indicated that increase in the applied voltage value and rotation speed of the collector led to more uniform fibers with higher diameter and larger pores, suitable for tissue regeneration applications, such as periodontal tissue regeneration. |
| first_indexed | 2024-03-09T20:27:53Z |
| format | Article |
| id | doaj.art-191be02ba4a94467bc73305dcc59763e |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T20:27:53Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-191be02ba4a94467bc73305dcc59763e2023-11-23T23:31:06ZengMDPI AGNanomaterials2079-49912022-03-0112585010.3390/nano12050850Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal RegenerationGeorgia K. Pouroutzidou0Maria Lazaridou1Chrysanthi Papoulia2Ioannis Tsamesidis3Konstantinos Chrissafis4George Vourlias5Konstantinos M. Paraskevopoulos6Dimitrios Bikiaris7Eleana Kontonasaki8Advanced Materials and Devices Laboratory, Faculty of Sciences, School of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceFaculty of Sciences, School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceAdvanced Materials and Devices Laboratory, Faculty of Sciences, School of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceAdvanced Materials and Devices Laboratory, Faculty of Sciences, School of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceAdvanced Materials and Devices Laboratory, Faculty of Sciences, School of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceAdvanced Materials and Devices Laboratory, Faculty of Sciences, School of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceFaculty of Sciences, School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceEngineered electrospun membranes have emerged as promising materials in guided tissue regeneration, as they provide an appropriate framework for the formation of new functional periodontal tissues. The development of multifunctional local drug delivery systems with sustained release of drugs for prolonged infection control can be used in periodontal surgical interventions to simultaneously prohibit epithelium downgrowth and ensure proper healing and regeneration of damaged periodontal tissues. The aim of the present study was the fabrication of novel composite membranes from PLGA/moxifloxacin-loaded mesoporous nanocarriers through electrospinning and the evaluation of their drug release profiles. The addition of moxifloxacin-loaded mesoporous nanocarriers in PLGA yielded a sustained and prolonged drug release, while maintaining satisfactory mechanical strength. The freshly fabricated membranes were found to be biocompatible at masses less than 1 mg after exposure to healthy erythrocytes. Increase in the amount of polymer led to more uniform fibers with large diameters and pores. The study of the parameters of the electrospinning process indicated that increase in the applied voltage value and rotation speed of the collector led to more uniform fibers with higher diameter and larger pores, suitable for tissue regeneration applications, such as periodontal tissue regeneration.https://www.mdpi.com/2079-4991/12/5/850electrospun membranesmesoporous nanoparticlesdrug deliveryMCM-41moxifloxacinPLGA |
| spellingShingle | Georgia K. Pouroutzidou Maria Lazaridou Chrysanthi Papoulia Ioannis Tsamesidis Konstantinos Chrissafis George Vourlias Konstantinos M. Paraskevopoulos Dimitrios Bikiaris Eleana Kontonasaki Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration Nanomaterials electrospun membranes mesoporous nanoparticles drug delivery MCM-41 moxifloxacin PLGA |
| title | Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration |
| title_full | Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration |
| title_fullStr | Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration |
| title_full_unstemmed | Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration |
| title_short | Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration |
| title_sort | electrospun plga membranes with incorporated moxifloxacin loaded silica based mesoporous nanocarriers for periodontal regeneration |
| topic | electrospun membranes mesoporous nanoparticles drug delivery MCM-41 moxifloxacin PLGA |
| url | https://www.mdpi.com/2079-4991/12/5/850 |
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