Plasma Retinoid Concentrations Are Altered in Pregnant Women
Vitamin A is vital to maternal–fetal health and pregnancy outcomes. However, little is known about pregnancy associated changes in maternal vitamin A homeostasis and concentrations of circulating retinol metabolites. The goal of this study was to characterize retinoid concentrations in healthy women...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1365 |
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| author | Lindsay C. Czuba Emily E. Fay Jeffrey LaFrance Chase K. Smith Sara Shum Sue L. Moreni Jennie Mao Nina Isoherranen Mary F. Hebert |
| author_facet | Lindsay C. Czuba Emily E. Fay Jeffrey LaFrance Chase K. Smith Sara Shum Sue L. Moreni Jennie Mao Nina Isoherranen Mary F. Hebert |
| author_sort | Lindsay C. Czuba |
| collection | DOAJ |
| description | Vitamin A is vital to maternal–fetal health and pregnancy outcomes. However, little is known about pregnancy associated changes in maternal vitamin A homeostasis and concentrations of circulating retinol metabolites. The goal of this study was to characterize retinoid concentrations in healthy women (<i>n</i> = 23) during two stages of pregnancy (25–28 weeks gestation and 28–32 weeks gestation) as compared to ≥3 months postpartum. It was hypothesized that plasma retinol, retinol binding protein 4 (RBP4), transthyretin and albumin concentrations would decline during pregnancy and return to baseline by 3 months postpartum. At 25–28 weeks gestation, plasma retinol (−27%), 4-oxo-13-<i>cis</i>-retinoic acid (−34%), and albumin (−22%) concentrations were significantly lower, and <i>all-trans</i>-retinoic acid (+48%) concentrations were significantly higher compared to ≥3 months postpartum in healthy women. In addition, at 28–32 weeks gestation, plasma retinol (−41%), retinol binding protein 4 (RBP4; −17%), transthyretin (TTR; −21%), albumin (−26%), 13-<i>cis</i>-retinoic acid (−23%) and 4-oxo-13-<i>cis</i>-retinoic acid (−48%) concentrations were significantly lower, whereas plasma <i>all-trans</i>-retinoic acid concentrations (+30%) were significantly higher than ≥3 months postpartum. Collectively, the data demonstrates that in healthy pregnancies, retinol plasma concentrations are lower, but <i>all-trans</i>-retinoic acid concentrations are higher than postpartum. |
| first_indexed | 2024-03-09T11:33:15Z |
| format | Article |
| id | doaj.art-191dff43c9464008b5bde2c416c11ed3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:33:15Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-191dff43c9464008b5bde2c416c11ed32023-11-30T23:47:11ZengMDPI AGNutrients2072-66432022-03-01147136510.3390/nu14071365Plasma Retinoid Concentrations Are Altered in Pregnant WomenLindsay C. Czuba0Emily E. Fay1Jeffrey LaFrance2Chase K. Smith3Sara Shum4Sue L. Moreni5Jennie Mao6Nina Isoherranen7Mary F. Hebert8Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USADepartment of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USADepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USADepartment of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA 98195, USADepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USADepartment of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USADepartment of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USADepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USADepartment of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USAVitamin A is vital to maternal–fetal health and pregnancy outcomes. However, little is known about pregnancy associated changes in maternal vitamin A homeostasis and concentrations of circulating retinol metabolites. The goal of this study was to characterize retinoid concentrations in healthy women (<i>n</i> = 23) during two stages of pregnancy (25–28 weeks gestation and 28–32 weeks gestation) as compared to ≥3 months postpartum. It was hypothesized that plasma retinol, retinol binding protein 4 (RBP4), transthyretin and albumin concentrations would decline during pregnancy and return to baseline by 3 months postpartum. At 25–28 weeks gestation, plasma retinol (−27%), 4-oxo-13-<i>cis</i>-retinoic acid (−34%), and albumin (−22%) concentrations were significantly lower, and <i>all-trans</i>-retinoic acid (+48%) concentrations were significantly higher compared to ≥3 months postpartum in healthy women. In addition, at 28–32 weeks gestation, plasma retinol (−41%), retinol binding protein 4 (RBP4; −17%), transthyretin (TTR; −21%), albumin (−26%), 13-<i>cis</i>-retinoic acid (−23%) and 4-oxo-13-<i>cis</i>-retinoic acid (−48%) concentrations were significantly lower, whereas plasma <i>all-trans</i>-retinoic acid concentrations (+30%) were significantly higher than ≥3 months postpartum. Collectively, the data demonstrates that in healthy pregnancies, retinol plasma concentrations are lower, but <i>all-trans</i>-retinoic acid concentrations are higher than postpartum.https://www.mdpi.com/2072-6643/14/7/1365vitamin Aretinoidpregnancypostpartumretinol-binding protein 4 (RBP4)transthyretin (TTR) |
| spellingShingle | Lindsay C. Czuba Emily E. Fay Jeffrey LaFrance Chase K. Smith Sara Shum Sue L. Moreni Jennie Mao Nina Isoherranen Mary F. Hebert Plasma Retinoid Concentrations Are Altered in Pregnant Women Nutrients vitamin A retinoid pregnancy postpartum retinol-binding protein 4 (RBP4) transthyretin (TTR) |
| title | Plasma Retinoid Concentrations Are Altered in Pregnant Women |
| title_full | Plasma Retinoid Concentrations Are Altered in Pregnant Women |
| title_fullStr | Plasma Retinoid Concentrations Are Altered in Pregnant Women |
| title_full_unstemmed | Plasma Retinoid Concentrations Are Altered in Pregnant Women |
| title_short | Plasma Retinoid Concentrations Are Altered in Pregnant Women |
| title_sort | plasma retinoid concentrations are altered in pregnant women |
| topic | vitamin A retinoid pregnancy postpartum retinol-binding protein 4 (RBP4) transthyretin (TTR) |
| url | https://www.mdpi.com/2072-6643/14/7/1365 |
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