A Public Database of Memory and Naive B-Cell Receptor Sequences.
The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity has also limited our understanding of humoral immunity. We present a public database of more than 37 million unique BCR sequences from three...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4981401?pdf=render |
| _version_ | 1818026180355293184 |
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| author | William S DeWitt Paul Lindau Thomas M Snyder Anna M Sherwood Marissa Vignali Christopher S Carlson Philip D Greenberg Natalie Duerkopp Ryan O Emerson Harlan S Robins |
| author_facet | William S DeWitt Paul Lindau Thomas M Snyder Anna M Sherwood Marissa Vignali Christopher S Carlson Philip D Greenberg Natalie Duerkopp Ryan O Emerson Harlan S Robins |
| author_sort | William S DeWitt |
| collection | DOAJ |
| description | The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity has also limited our understanding of humoral immunity. We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. We estimate the clonal diversity of the naive and memory B-cell repertoires of healthy individuals, and provide a set of examples that illustrate the utility of the database, including several views of the basic properties of immunoglobulin heavy chain sequences, such as rearrangement length, subunit usage, and somatic hypermutation positions and dynamics. |
| first_indexed | 2024-12-10T04:27:54Z |
| format | Article |
| id | doaj.art-1920199887e44a0792c0ea7d7902df16 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T04:27:54Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1920199887e44a0792c0ea7d7902df162022-12-22T02:02:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01118e016085310.1371/journal.pone.0160853A Public Database of Memory and Naive B-Cell Receptor Sequences.William S DeWittPaul LindauThomas M SnyderAnna M SherwoodMarissa VignaliChristopher S CarlsonPhilip D GreenbergNatalie DuerkoppRyan O EmersonHarlan S RobinsThe vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity has also limited our understanding of humoral immunity. We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. We estimate the clonal diversity of the naive and memory B-cell repertoires of healthy individuals, and provide a set of examples that illustrate the utility of the database, including several views of the basic properties of immunoglobulin heavy chain sequences, such as rearrangement length, subunit usage, and somatic hypermutation positions and dynamics.http://europepmc.org/articles/PMC4981401?pdf=render |
| spellingShingle | William S DeWitt Paul Lindau Thomas M Snyder Anna M Sherwood Marissa Vignali Christopher S Carlson Philip D Greenberg Natalie Duerkopp Ryan O Emerson Harlan S Robins A Public Database of Memory and Naive B-Cell Receptor Sequences. PLoS ONE |
| title | A Public Database of Memory and Naive B-Cell Receptor Sequences. |
| title_full | A Public Database of Memory and Naive B-Cell Receptor Sequences. |
| title_fullStr | A Public Database of Memory and Naive B-Cell Receptor Sequences. |
| title_full_unstemmed | A Public Database of Memory and Naive B-Cell Receptor Sequences. |
| title_short | A Public Database of Memory and Naive B-Cell Receptor Sequences. |
| title_sort | public database of memory and naive b cell receptor sequences |
| url | http://europepmc.org/articles/PMC4981401?pdf=render |
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