Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study.
INTRODUCTION:Screening of young women is often discouraged because of the high risk of unnecessary diagnostics or overtreatment. Multiple countries therefore use cytology instead of high risk human papillomavirus (hrHPV)-testing as screening method for young women because of the limited specificity...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6200272?pdf=render |
| _version_ | 1818317913758629888 |
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| author | Renée M F Ebisch Pleun J W Ketelaars Wouter M H van der Sanden Channa E Schmeink Charlotte H Lenselink Albert G Siebers Leon F A G Massuger Willem J G Melchers Ruud L M Bekkers |
| author_facet | Renée M F Ebisch Pleun J W Ketelaars Wouter M H van der Sanden Channa E Schmeink Charlotte H Lenselink Albert G Siebers Leon F A G Massuger Willem J G Melchers Ruud L M Bekkers |
| author_sort | Renée M F Ebisch |
| collection | DOAJ |
| description | INTRODUCTION:Screening of young women is often discouraged because of the high risk of unnecessary diagnostics or overtreatment. Multiple countries therefore use cytology instead of high risk human papillomavirus (hrHPV)-testing as screening method for young women because of the limited specificity of hrHPV-testing. The objective of this study was to investigate how hrHPV screening before the age of 30, can be used to reduce the future prevalence of high-grade cervical lesions in young women. METHODS:We retrospectively analyzed follow-up data from a cohort study on HPV prevalence in unscreened Dutch women aged 18-29 years. Women performed multiple self-collected cervico-vaginal samples for HPV detection and genotyping. At least one valid cervical pathology result was obtained from 1,018 women. Women were categorized as hrHPV negative, cleared- or persistent hrHPV infection. Anonymized follow-up data for each group was obtained. Composite outcome measures were defined as; normal, low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL). The association between prior hrHPV status and cytology and histology outcome was analyzed. RESULTS:After exclusion, a pathology result was registered for 962 women. The prevalence of HSIL was 19.3% in women with a persistent HPV infection at a younger age. This is significantly higher (p<0,001) compared with the HSIL prevalence of 1.5% in HPV-negative women, and 3.1% (n = 8) in women who cleared the hrHPV infection in the past. CONCLUSION:Women with a persistent hrHPV infection in their 20s, show an increased prevalence of HSIL lesions in their early 30s. Screening for persistent hrHPV infections, instead of cytology screening before the age of 30, can be used to reduce the future prevalence of cervical cancer in young women. |
| first_indexed | 2024-12-13T09:44:53Z |
| format | Article |
| id | doaj.art-19212f300f7c42f6a4d9cfaeee7281e0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T09:44:53Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-19212f300f7c42f6a4d9cfaeee7281e02022-12-21T23:52:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020621910.1371/journal.pone.0206219Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study.Renée M F EbischPleun J W KetelaarsWouter M H van der SandenChanna E SchmeinkCharlotte H LenselinkAlbert G SiebersLeon F A G MassugerWillem J G MelchersRuud L M BekkersINTRODUCTION:Screening of young women is often discouraged because of the high risk of unnecessary diagnostics or overtreatment. Multiple countries therefore use cytology instead of high risk human papillomavirus (hrHPV)-testing as screening method for young women because of the limited specificity of hrHPV-testing. The objective of this study was to investigate how hrHPV screening before the age of 30, can be used to reduce the future prevalence of high-grade cervical lesions in young women. METHODS:We retrospectively analyzed follow-up data from a cohort study on HPV prevalence in unscreened Dutch women aged 18-29 years. Women performed multiple self-collected cervico-vaginal samples for HPV detection and genotyping. At least one valid cervical pathology result was obtained from 1,018 women. Women were categorized as hrHPV negative, cleared- or persistent hrHPV infection. Anonymized follow-up data for each group was obtained. Composite outcome measures were defined as; normal, low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL). The association between prior hrHPV status and cytology and histology outcome was analyzed. RESULTS:After exclusion, a pathology result was registered for 962 women. The prevalence of HSIL was 19.3% in women with a persistent HPV infection at a younger age. This is significantly higher (p<0,001) compared with the HSIL prevalence of 1.5% in HPV-negative women, and 3.1% (n = 8) in women who cleared the hrHPV infection in the past. CONCLUSION:Women with a persistent hrHPV infection in their 20s, show an increased prevalence of HSIL lesions in their early 30s. Screening for persistent hrHPV infections, instead of cytology screening before the age of 30, can be used to reduce the future prevalence of cervical cancer in young women.http://europepmc.org/articles/PMC6200272?pdf=render |
| spellingShingle | Renée M F Ebisch Pleun J W Ketelaars Wouter M H van der Sanden Channa E Schmeink Charlotte H Lenselink Albert G Siebers Leon F A G Massuger Willem J G Melchers Ruud L M Bekkers Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study. PLoS ONE |
| title | Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study. |
| title_full | Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study. |
| title_fullStr | Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study. |
| title_full_unstemmed | Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study. |
| title_short | Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study. |
| title_sort | screening for persistent high risk hpv infections may be a valuable screening method for young women a retrospective cohort study |
| url | http://europepmc.org/articles/PMC6200272?pdf=render |
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