Garcinol Attenuates Lipoprotein(a)-Induced Oxidative Stress and Inflammatory Cytokine Production in Ventricular Cardiomyocyte through α7-Nicotinic Acetylcholine Receptor-Mediated Inhibition of the p38 MAPK and NF-κB Signaling Pathways

Garcinol Attenuates Lipoprotein(a)-Induced Oxidative Stress and Inflammatory Cytokine Production in Ventricular Cardiomyocyte through α7-Nicotinic Acetylcholine Receptor-Mediated Inhibition of the p38 MAPK and NF-κB Signaling Pathways

Garcinol, a nicotinic acetylcholine receptor (nAChR) antagonist, has recently been established as an anti-inflammation agent. However, the molecular mechanism by which garcinol suppresses inflammation in the context of acute myocardial infarction (AMI) remains unclear. <b>Hypothesis:</b>...

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Bibliographic Details
Main Authors: Nen-Chung Chang, Chi-Tai Yeh, Yen-Kuang Lin, Kuang-Tai Kuo, Iat-Hang Fong, Nicholas G. Kounis, Patrick Hu, Ming-Yow Hung
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
garcinol
nicotinic receptor
α7-nAChR
NF-κB signaling
Online Access:https://www.mdpi.com/2076-3921/10/3/461

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