The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 study
Abstract Background The use of psychotropics is high among the older population and may have detrimental effects on their physical and mental health. Cardiorespiratory fitness (CRF) is a strong and modifiable measure of health and declines with age. We aimed to study the association of change in CRF...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-03262-6 |
| _version_ | 1811293622203580416 |
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| author | Trude Carlsen Dorthe Stensvold Ulrik Wisløff Linda Ernstsen Thomas Halvorsen |
| author_facet | Trude Carlsen Dorthe Stensvold Ulrik Wisløff Linda Ernstsen Thomas Halvorsen |
| author_sort | Trude Carlsen |
| collection | DOAJ |
| description | Abstract Background The use of psychotropics is high among the older population and may have detrimental effects on their physical and mental health. Cardiorespiratory fitness (CRF) is a strong and modifiable measure of health and declines with age. We aimed to study the association of change in CRF with use of psychotropics in community-dwelling older adults. Methods We analyzed longitudinal data from 1531 older adults from the Generation 100 study, aged 70–77 years at inclusion, and with a permanent address in Trondheim, Norway. Data on objectively measured peak oxygen uptake (VO2peak) were linked with register data from the Norwegian Prescription Database on prescribed psychotropics. The included psychotropics were antidepressants (N06A), antipsychotics (N05A), anxiolytics (N05B), hypnotics and sedatives (N05C), and N03AE (benzodiazepine derivatives). Analyses were done on any psychotropics as one group, and on the following separate groups: antidepressants (N06A), benzodiazepines (N05BA, N05CD, and N03AE), and z-hypnotics (N05CF). Peak oxygen uptake was measured four times over a five-year period and corresponding medication use was measured as defined daily doses (DDD). A random effects estimator was applied to investigate the association of change in VO2peak with the use of psychotropics. Results We found a statistically significant curvilinear association of change in VO2peak with use of any psychotropics and antidepressants. For VO2peak up to ~ 40 ml/kg/min, each 1 ml/kg/min increase was associated by a 3.3 DDD and 2.5 DDD decrease in use of any psychotropics and antidepressants, respectively. A bottoming-out effect was found and increases in VO2peak above ~ 40 ml/kg/min showed increased use of any psychotropics and antidepressants. However, the association of change in VO2peak with use was stronger for changes in the lower continuum of VO2peak levels and decreased with increasing VO2peak. No statistically significant association of change in VO2peak with use of benzodiazepines and z-hypnotics were found. However, because of a non-randomized design, we cannot rule out the possibility of confounding by indication. Conclusions The results of this study show a curvilinear association of change in VO2peak with use of any psychotropics and antidepressants in older adults. This relationship adds a new viewpoint on the adverse effects of psychotropic use and should be considered in interventions and policies aimed at reducing psychotropic medication use among the older population. |
| first_indexed | 2024-04-13T05:04:12Z |
| format | Article |
| id | doaj.art-19234e6b5023494f9afea4b8c036071c |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-13T05:04:12Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-19234e6b5023494f9afea4b8c036071c2022-12-22T03:01:14ZengBMCBMC Geriatrics1471-23182022-07-0122111010.1186/s12877-022-03262-6The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 studyTrude Carlsen0Dorthe Stensvold1Ulrik Wisløff2Linda Ernstsen3Thomas Halvorsen4The Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyThe Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyThe Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Geography, Faculty of Social and Educational Sciences, Norwegian University of Science and TechnologyAbstract Background The use of psychotropics is high among the older population and may have detrimental effects on their physical and mental health. Cardiorespiratory fitness (CRF) is a strong and modifiable measure of health and declines with age. We aimed to study the association of change in CRF with use of psychotropics in community-dwelling older adults. Methods We analyzed longitudinal data from 1531 older adults from the Generation 100 study, aged 70–77 years at inclusion, and with a permanent address in Trondheim, Norway. Data on objectively measured peak oxygen uptake (VO2peak) were linked with register data from the Norwegian Prescription Database on prescribed psychotropics. The included psychotropics were antidepressants (N06A), antipsychotics (N05A), anxiolytics (N05B), hypnotics and sedatives (N05C), and N03AE (benzodiazepine derivatives). Analyses were done on any psychotropics as one group, and on the following separate groups: antidepressants (N06A), benzodiazepines (N05BA, N05CD, and N03AE), and z-hypnotics (N05CF). Peak oxygen uptake was measured four times over a five-year period and corresponding medication use was measured as defined daily doses (DDD). A random effects estimator was applied to investigate the association of change in VO2peak with the use of psychotropics. Results We found a statistically significant curvilinear association of change in VO2peak with use of any psychotropics and antidepressants. For VO2peak up to ~ 40 ml/kg/min, each 1 ml/kg/min increase was associated by a 3.3 DDD and 2.5 DDD decrease in use of any psychotropics and antidepressants, respectively. A bottoming-out effect was found and increases in VO2peak above ~ 40 ml/kg/min showed increased use of any psychotropics and antidepressants. However, the association of change in VO2peak with use was stronger for changes in the lower continuum of VO2peak levels and decreased with increasing VO2peak. No statistically significant association of change in VO2peak with use of benzodiazepines and z-hypnotics were found. However, because of a non-randomized design, we cannot rule out the possibility of confounding by indication. Conclusions The results of this study show a curvilinear association of change in VO2peak with use of any psychotropics and antidepressants in older adults. This relationship adds a new viewpoint on the adverse effects of psychotropic use and should be considered in interventions and policies aimed at reducing psychotropic medication use among the older population.https://doi.org/10.1186/s12877-022-03262-6AgedCardiorespiratory fitnessExerciseAntidepressantsBenzodiazepinesZ-hypnotics |
| spellingShingle | Trude Carlsen Dorthe Stensvold Ulrik Wisløff Linda Ernstsen Thomas Halvorsen The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 study BMC Geriatrics Aged Cardiorespiratory fitness Exercise Antidepressants Benzodiazepines Z-hypnotics |
| title | The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 study |
| title_full | The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 study |
| title_fullStr | The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 study |
| title_full_unstemmed | The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 study |
| title_short | The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 study |
| title_sort | association of change in peak oxygen uptake with use of psychotropics in community dwelling older adults the generation 100 study |
| topic | Aged Cardiorespiratory fitness Exercise Antidepressants Benzodiazepines Z-hypnotics |
| url | https://doi.org/10.1186/s12877-022-03262-6 |
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