Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)
In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Amon...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-03-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/9/3/23 |
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| author | Yutaka Yonemura Yoshio Endo Emel Canbay Yang Liu Haruaki Ishibashi Akiyoshi Mizumoto Masamitu Hirano Yuuki Imazato Nobuyuki Takao Masumi Ichinose Kousuke Noguchi Yan Li Satoshi Wakama Kazuhiro Yamada Koutarou Hatano Hiroshi Shintani Hiroyuki Yoshitake Shun-ichiro Ogura |
| author_facet | Yutaka Yonemura Yoshio Endo Emel Canbay Yang Liu Haruaki Ishibashi Akiyoshi Mizumoto Masamitu Hirano Yuuki Imazato Nobuyuki Takao Masumi Ichinose Kousuke Noguchi Yan Li Satoshi Wakama Kazuhiro Yamada Koutarou Hatano Hiroshi Shintani Hiroyuki Yoshitake Shun-ichiro Ogura |
| author_sort | Yutaka Yonemura |
| collection | DOAJ |
| description | In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM. |
| first_indexed | 2024-03-12T09:09:38Z |
| format | Article |
| id | doaj.art-19248d3c458742eba67281d1e4771a44 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:09:38Z |
| publishDate | 2017-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-19248d3c458742eba67281d1e4771a442023-09-02T15:04:26ZengMDPI AGCancers2072-66942017-03-01932310.3390/cancers9030023cancers9030023Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)Yutaka Yonemura0Yoshio Endo1Emel Canbay2Yang Liu3Haruaki Ishibashi4Akiyoshi Mizumoto5Masamitu Hirano6Yuuki Imazato7Nobuyuki Takao8Masumi Ichinose9Kousuke Noguchi10Yan Li11Satoshi Wakama12Kazuhiro Yamada13Koutarou Hatano14Hiroshi Shintani15Hiroyuki Yoshitake16Shun-ichiro Ogura17NPO Organization to support Peritoneal Surface Malignancy Treatment, 510 Fukushima-Cho, Shimogyou-Ku, Kyoto 600-8189, JapanCentral Research Resource Center, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, JapanNPO HIPEC Istanbul, Guzelbahce Sokak No:15 Nisantasi, Istanbul 34367, TurkeyPeritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, JapanNPO Organization to support Peritoneal Surface Malignancy Treatment, 510 Fukushima-Cho, Shimogyou-Ku, Kyoto 600-8189, JapanDepartment of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, JapanDepartment of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, JapanDepartment of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, JapanDepartment of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, JapanDepartment of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, JapanDepartment of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, JapanDepartment of Peritoneal Surface Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, ChinaPeritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, JapanPeritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, JapanPeritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, JapanPeritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, JapanPeritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, JapanGraduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsu-Cho, Midori-ku, Yokohama 226-8501, JapanIn the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM.http://www.mdpi.com/2072-6694/9/3/23aminolevulinic acidphotodynamic diagnosis (PDD)peritoneal surface malignanciesPEPT1ABCG2ferrochelatase |
| spellingShingle | Yutaka Yonemura Yoshio Endo Emel Canbay Yang Liu Haruaki Ishibashi Akiyoshi Mizumoto Masamitu Hirano Yuuki Imazato Nobuyuki Takao Masumi Ichinose Kousuke Noguchi Yan Li Satoshi Wakama Kazuhiro Yamada Koutarou Hatano Hiroshi Shintani Hiroyuki Yoshitake Shun-ichiro Ogura Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA) Cancers aminolevulinic acid photodynamic diagnosis (PDD) peritoneal surface malignancies PEPT1 ABCG2 ferrochelatase |
| title | Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA) |
| title_full | Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA) |
| title_fullStr | Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA) |
| title_full_unstemmed | Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA) |
| title_short | Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA) |
| title_sort | photodynamic detection of peritoneal metastases using 5 aminolevulinic acid ala |
| topic | aminolevulinic acid photodynamic diagnosis (PDD) peritoneal surface malignancies PEPT1 ABCG2 ferrochelatase |
| url | http://www.mdpi.com/2072-6694/9/3/23 |
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