Polymorphisms at rs368698783 and rs7482144 loci in the promoter region of the HBG gene are associated with HbF expression

Polymorphisms at rs368698783 and rs7482144 loci in the promoter region of the HBG gene are associated with HbF expression

Objective To investigate the correlation between rs368698783 and rs7482144 locus and fetal hemoglobin (HbF) expression in β-thalassemia patients of Yunan province. Methods A total of 579 samples were collected, including 51 samples of β-thalassaemia, 40 samples with HbE, 113 samples of HbF＞5%(βN/β...

Full description

Bibliographic Details
Main Author:	DENG Ling, LONG Lan, YANG Yang, JIN Chanchan, LI Suyun, FENG Na, HE Jing
Format:	Article
Language:	zho
Published:	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2023-02-01
Series:	Jichu yixue yu linchuang
Subjects:	β-thalassemia\|fetal hemoglobin\|rs368698783\|rs7482144
Online Access:	http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-2-211.pdf

Similar Items

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the <i>Aγ-Globin</i> Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
by: Cristina Zuccato, et al.
Published: (2023-01-01)

HBG2 -158 (C>T) polymorphism and its contribution to fetal hemoglobin variability in Iraqi Kurds with beta-thalassemia minor
by: Dilan J. Albarawi, et al.
Published: (2018-10-01)

Combined approaches for increasing fetal hemoglobin (HbF) and de novo production of adult hemoglobin (HbA) in erythroid cells from β-thalassemia patients: treatment with HbF inducers and CRISPR-Cas9 based genome editing
by: Alessia Finotti, et al.
Published: (2023-07-01)

Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis
by: Vasileios Siokas, et al.
Published: (2022-03-01)

Association of single nucleotide polymorphisms rs7164665, rs71461059, rs74765750, rs6762529 with sudden cardiac death
by: A. A. Ivanova, et al.
Published: (2019-11-01)

BDNF rs10501087, rs1491850 and rs11030094 polymorphisms associated with delayed progression in early-stage Parkinson's disease
by: D. Luke Fischer, et al.
Published: (2022-11-01)

Influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis subject to sex belonging in Russian ethnic group
by: Ye. V. Khanokh, et al.
Published: (2011-04-01)

Associations of the APOB rs693 and rs17240441 polymorphisms with plasma APOB and lipid levels: a meta-analysis
by: Caiqin Niu, et al.
Published: (2017-09-01)

Single nucleotide variants rs6582147, rs10010305, rs2136810, rs17797829 as new molecular genetic markers of sudden cardiac death
by: A. A. Ivanova, et al.
Published: (2018-11-01)

Assessment of post-menopausal osteoporosis development risk: role of polymorphisms RS1800012, RS1107946 of a gene of COL1A1 and RS731236 and RS11568820 of a gene of VDR
by: D. S. Zyablicev, et al.
Published: (2015-02-01)

Optic Neuritis: The Influence of Gene Polymorphisms and Serum Levels of <i>STAT4</i> (rs10181656, rs7574865, rs7601754, rs10168266)
by: Greta Gedvilaite, et al.
Published: (2023-12-01)

Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis
by: Xuemei Hu, et al.
Published: (2022-06-01)

Corrigendum: Association of single-nucleotide polymorphisms of rs2383206, rs2383207, and rs10757278 with stroke risk in the Chinese population: A meta-analysis
by: Xuemei Hu, et al.
Published: (2022-10-01)

Association of T715P (RS6136), M62I (RS2228315), S290N (RS6131), V640L (RS6133) polymorphisms in the P-selectin gene and its ligand with acetylsalicylic acid resistance in patients with coronary artery disease after coronary artery bypass grafting
by: A. A. Kosinova, et al.
Published: (2019-11-01)

Role of polymorphic loci <i>VDR</i> rs10735810, <i>MTHFR</i> rs1801131, <i>MTHFR</i> rs1801133, <i>MTR</i> rs1805087,<i> MTRR</i> rs1801394 AND <i>VEGFA</i> rs3025039 in missed abortion: A prospective cohort study
by: F. U. Ramazanova, et al.
Published: (2022-06-01)

The single nucleotide polymorphisms rs11761556 and rs12706832 of the leptin gene are associated with type 2 diabetes mellitus in the Iraqi population
by: Musafer Karar N.J., et al.
Published: (2021-01-01)

Adipocyte “Fatty Acid Binding Protein” Gene Polymorphisms (rs1054135, rs16909196 and rs16909187) in Jordanians with Obesity and Type 2 Diabetes Mellitus
by: El-Ryalat S.W., et al.
Published: (2022-12-01)

Association of rs 10038177 and rs 1971050 Polymorphism of WDR 36 Gene with Clinical Profile in POAG Patients
by: Mehvish MALIK, et al.
Published: (2021-12-01)

ESR2 gene variants (rs1256049, rs4986938, and rs1256030) and their association with breast cancer risk
by: Martha Patricia Gallegos-Arreola, et al.
Published: (2022-05-01)

Novel therapeutic agents for HbF induction: a new era for treatment of β thalassemia?
by: S.P. Perrine
Published: (2011-12-01)

Haplotypic and Genotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia
by: Marina Sagud, et al.
Published: (2018-07-01)

Assessment of post-menopausal osteoporosis development risk: role of polymorphisms RS1800012, RS1107946 of a gene of COL1A1 and RS731236 and RS11568820 of a gene of VDR
by: D. S. Zyablicev, et al.
Published: (2015-02-01)

The survival rate of laryngeal squamous cell carcinoma: impact of IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, BLK rs13277113, and TIMP3 rs9621532 single nucleotide polymorphisms
by: Agne Pasvenskaite, et al.
Published: (2023-01-01)

IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients
by: Natalia Echeverría, et al.
Published: (2018-03-01)

Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population
by: Haibo Ma, et al.
Published: (2019-11-01)

Association of TP53 rs1042522 G > C, MDM2 rs2279744 T > G, and miR-34b/c rs4938723 T > C polymorphisms with aneuploidy pregnancy susceptibility
by: Ying Chan, et al.
Published: (2023-08-01)

Association of single-nucleotide polymorphisms rs10867772, rs4700290 with sudden cardiac death
by: A. A. Ivanova, et al.
Published: (2021-03-01)

Association of single nucleotide polymorphisms rs61999948, rs7172856 with sudden cardiac death
by: A. A. Ivanova, et al.
Published: (2019-12-01)

Molecular Analysis of rs2070744 and rs1799983 Polymorphisms of NOS3 Gene in Iranian Patients With Multiple Sclerosis
by: Mohammad Mehdi Heidari, et al.
Published: (2017-07-01)

The influence of rs53576 and rs2254298 oxytocin receptor gene polymorphisms on plasma oxytocin levels and measures of empathy
by: Bašić Jelena, et al.
Published: (2019-01-01)

Evaluation of the influence of single-nucleotide polymorphisms of vitamin D receptor (rs2228570), BDNF (rs6265), and NMDA (rs4880213) genes on gene expression in different tissues
by: I. Kamyshna, et al.
Published: (2023-04-01)

Association of HLA rs3135388 and rs9271366 Single-Nucleotide Polymorphisms With Multiple Sclerosis in the Chaharmahal and Bakhtiari Province, Iran
by: Shahrbanou Parchami Barjui, et al.
Published: (2023-12-01)

rs3761548 (C/A) and rs5902434 (del/ATT) polymorphisms of Foxp3 gene in Iranian patients with migraine
by: Fardin Faraji, et al.
Published: (2023-02-01)

Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer
by: Atefeh Liravi, et al.
Published: (2022-11-01)

Angiotensinogen (AGT) gene missense polymorphisms (rs699 and rs4762) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus
by: Jana Makuc, et al.
Published: (2017-08-01)

rs7041 and rs4588 Polymorphisms in Vitamin D Binding Protein Gene (VDBP) and the Risk of Diseases
by: Dominika Rozmus, et al.
Published: (2022-01-01)

Association of CCL4 rs10491121 and rs1634507 gene polymorphisms with cancer susceptibility: trial sequential analysis and meta-analysis
by: Changsen Yang, et al.
Published: (2023-08-01)

Molecular Analysis of HS-111 and 3`HS1 Variations in β-Thalassemia Intermedia Patients with High Levels of HbF
by: Mohammad Hamid, et al.
Published: (2010-01-01)

The MDR1/ABCB1 gene rs1045642 polymorphism in colorectal cancer
by: Beata Mrozikiewicz-Rakowska, et al.
Published: (2019-12-01)

Intronic polymorphisms in genes LRFN2 (rs2494938) and DNAH11 (rs2285947) are prognostic indicators of esophageal squamous cell carcinoma
by: Jiru Wang, et al.
Published: (2019-05-01)