A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!
<p>Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone ref...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2011-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v07p0815.htm |
| _version_ | 1819171544644976640 |
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| author | Zhiyong Guo, Yun Qiu |
| author_facet | Zhiyong Guo, Yun Qiu |
| author_sort | Zhiyong Guo, Yun Qiu |
| collection | DOAJ |
| description | <p>Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone refractory) prostate cancer. The underlying mechanisms are the focus of intensive investigation for development of more effective treatment. Mounting evidence from both clinical and basic research has demonstrated that the activity of the androgen receptor (AR) is still required for castration-resistant prostate cancer. Multiple mechanisms by which AR is re-activated under androgen-depleted conditions may be involved in the development of castration resistance. The recent identification of AR splicing variants may add another layer of complexity in AR biology. The present review summarizes recent progress in study of AR splicing variants in prostate cancer.</p> |
| first_indexed | 2024-12-22T19:52:59Z |
| format | Article |
| id | doaj.art-1925e5a9c5ec4471bc500aaab35c383a |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-12-22T19:52:59Z |
| publishDate | 2011-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-1925e5a9c5ec4471bc500aaab35c383a2022-12-21T18:14:29ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882011-01-0176815822A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!Zhiyong Guo, Yun Qiu<p>Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone refractory) prostate cancer. The underlying mechanisms are the focus of intensive investigation for development of more effective treatment. Mounting evidence from both clinical and basic research has demonstrated that the activity of the androgen receptor (AR) is still required for castration-resistant prostate cancer. Multiple mechanisms by which AR is re-activated under androgen-depleted conditions may be involved in the development of castration resistance. The recent identification of AR splicing variants may add another layer of complexity in AR biology. The present review summarizes recent progress in study of AR splicing variants in prostate cancer.</p>http://www.biolsci.org/v07p0815.htm |
| spellingShingle | Zhiyong Guo, Yun Qiu A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?! International Journal of Biological Sciences |
| title | A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?! |
| title_full | A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?! |
| title_fullStr | A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?! |
| title_full_unstemmed | A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?! |
| title_short | A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?! |
| title_sort | new trick of an old molecule androgen receptor splice variants taking the stage |
| url | http://www.biolsci.org/v07p0815.htm |
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