POLYEXTRACTION OF HERBS OF ECHINACEA BY SYSTEMS OF EXTRACENTS WITH RISING POLARITY
The process of extracting the Echinacea herbs (Echinacea Moench) has been developed with a series of water-alcohol solutions with an alcohol concentration of 70%, 40%, 20%. Extraction was carried out in the vacuum boiling mode with periodic pulsations of the vacuum. Such a regime provided high speed...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/606 |
| _version_ | 1797875009785430016 |
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| author | V. A. Vainshtein I. E. Kauhova P. S. Amelina Yu. A. Koldashova S. A. Minina A. V. Ivanova |
| author_facet | V. A. Vainshtein I. E. Kauhova P. S. Amelina Yu. A. Koldashova S. A. Minina A. V. Ivanova |
| author_sort | V. A. Vainshtein |
| collection | DOAJ |
| description | The process of extracting the Echinacea herbs (Echinacea Moench) has been developed with a series of water-alcohol solutions with an alcohol concentration of 70%, 40%, 20%. Extraction was carried out in the vacuum boiling mode with periodic pulsations of the vacuum. Such a regime provided high speed of the process and the possibility of extracting both lipophilic (chlorophyll derivatives, carotenoids) and hydrophilic (chicory acid and its derivatives) BAS. The kinetics of BAS extraction at three stages of maceration was studied: chicory acid is extracted by the polar extractant at all stages of extracting; the lipophilic components pass into the extraction at the stage of treatment with an alcoholconcentration of 70%. Method of micropreparative thin-layer chromatography with eluting and UV-analysis of the eluates was used to determine the groups of extractable BAS. A comparison of dry extracts obtained by water extraction, 24% alcohol extraction and extraction of a number of extractants with sequentially increasing polarity was made. It is established that the method of polyextraction allows to obtain a product containing the widest spectrum of BAS Echinacea. |
| first_indexed | 2024-04-10T01:39:51Z |
| format | Article |
| id | doaj.art-19274593a9ae4b8ea1ec583f147d996b |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:39:51Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-19274593a9ae4b8ea1ec583f147d996b2023-03-13T09:13:59ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01035463606POLYEXTRACTION OF HERBS OF ECHINACEA BY SYSTEMS OF EXTRACENTS WITH RISING POLARITYV. A. Vainshtein0I. E. Kauhova1P. S. Amelina2Yu. A. Koldashova3S. A. Minina4A. V. Ivanova5ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииThe process of extracting the Echinacea herbs (Echinacea Moench) has been developed with a series of water-alcohol solutions with an alcohol concentration of 70%, 40%, 20%. Extraction was carried out in the vacuum boiling mode with periodic pulsations of the vacuum. Such a regime provided high speed of the process and the possibility of extracting both lipophilic (chlorophyll derivatives, carotenoids) and hydrophilic (chicory acid and its derivatives) BAS. The kinetics of BAS extraction at three stages of maceration was studied: chicory acid is extracted by the polar extractant at all stages of extracting; the lipophilic components pass into the extraction at the stage of treatment with an alcoholconcentration of 70%. Method of micropreparative thin-layer chromatography with eluting and UV-analysis of the eluates was used to determine the groups of extractable BAS. A comparison of dry extracts obtained by water extraction, 24% alcohol extraction and extraction of a number of extractants with sequentially increasing polarity was made. It is established that the method of polyextraction allows to obtain a product containing the widest spectrum of BAS Echinacea.https://www.pharmjournal.ru/jour/article/view/606природные иммуномодуляторытрава эхинацеиэкстрагированиеуф-спектроскопиятсхцикориевая кислотаэхинакозид |
| spellingShingle | V. A. Vainshtein I. E. Kauhova P. S. Amelina Yu. A. Koldashova S. A. Minina A. V. Ivanova POLYEXTRACTION OF HERBS OF ECHINACEA BY SYSTEMS OF EXTRACENTS WITH RISING POLARITY Разработка и регистрация лекарственных средств природные иммуномодуляторы трава эхинацеи экстрагирование уф-спектроскопия тсх цикориевая кислота эхинакозид |
| title | POLYEXTRACTION OF HERBS OF ECHINACEA BY SYSTEMS OF EXTRACENTS WITH RISING POLARITY |
| title_full | POLYEXTRACTION OF HERBS OF ECHINACEA BY SYSTEMS OF EXTRACENTS WITH RISING POLARITY |
| title_fullStr | POLYEXTRACTION OF HERBS OF ECHINACEA BY SYSTEMS OF EXTRACENTS WITH RISING POLARITY |
| title_full_unstemmed | POLYEXTRACTION OF HERBS OF ECHINACEA BY SYSTEMS OF EXTRACENTS WITH RISING POLARITY |
| title_short | POLYEXTRACTION OF HERBS OF ECHINACEA BY SYSTEMS OF EXTRACENTS WITH RISING POLARITY |
| title_sort | polyextraction of herbs of echinacea by systems of extracents with rising polarity |
| topic | природные иммуномодуляторы трава эхинацеи экстрагирование уф-спектроскопия тсх цикориевая кислота эхинакозид |
| url | https://www.pharmjournal.ru/jour/article/view/606 |
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