Promiscuous Lipase-Catalyzed Markovnikov Addition of H-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives

Promiscuous Lipase-Catalyzed Markovnikov Addition of H-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives

An enzymatic route for phosphorous-carbon- bond formation is developed by discovering new promiscuous activity of lipase. This biocatalytic transformation of phosphorous-carbon- bond addition leads to biologically and pharmacologically relevant α-acyloxy phosphonates with methyl group in α-position....

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Bibliographic Details
Main Authors: Paweł Kowalczyk, Dominik Koszelewski, Barbara Gawdzik, Jan Samsonowicz-Górski, Karol Kramkowski, Aleksandra Wypych, Rafał Lizut, Ryszard Ostaszewski
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Materials
Subjects:
α-acyloxy phosphonates
enzymatic Markovnikov addition
lipase promiscuity
Fpg protein-formamidopyrimidine
lipopolysaccharide (LPS)
HIV-human immunodeficiency virus
Online Access:https://www.mdpi.com/1996-1944/15/5/1975

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