Detection of mutant antigen-specific T cell receptors against multiple myeloma for T cell engineering

Detection of mutant antigen-specific T cell receptors against multiple myeloma for T cell engineering

Multiple myeloma (MM) remains an incurable hematological neoplasm. Neoantigen-specific T cell receptor (TCR)-engineered T (TCR-T) cell therapy is a potential alternative treatment. Particularly, TCRs derived from a third-party donor may cover broad ranges of neoantigens, whereas TCRs in patients suf...

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Bibliographic Details
Main Authors: Masahiro Okada, Kanako Shimizu, Hiroshi Nakazato, Satoru Yamasaki, Shin-ichiro Fujii
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
neoantigens
multiple myeloma
TCR-T cell
single-cell TCR sequence
TCR cloning
adoptive cell transfer
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123000761

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