Endoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgery
Abstract Objective To investigate the application of endoscopic injection of human fibrin sealant in treatment of patients with intrathoracic anastomotic leakage after esophagectomy. Methods A total of 179 patients who underwent intrathoracic anastomosis after esophageal cancer surgery in our depart...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13019-020-01127-w |
| _version_ | 1828875689180266496 |
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| author | Xueyu Chen Xiaoqin Yuan Zhongyuan Chen Lianggang Zhu |
| author_facet | Xueyu Chen Xiaoqin Yuan Zhongyuan Chen Lianggang Zhu |
| author_sort | Xueyu Chen |
| collection | DOAJ |
| description | Abstract Objective To investigate the application of endoscopic injection of human fibrin sealant in treatment of patients with intrathoracic anastomotic leakage after esophagectomy. Methods A total of 179 patients who underwent intrathoracic anastomosis after esophageal cancer surgery in our department From December 2012 to May 2015 were retrospectively analyzed. The clinical data and treatment of 7 patients with postoperative intrathoracic anastomotic leakage were analyzed and discussed. On Day 28 after operation, the 7 patients were given endoscopic injection of human fibrin sealant to seal the anastomotic leakage, and the changes in drainage volume, body temperature, CRP, white blood cell count and other indicators were compared before and after endoscopic intervention. Results After endoscopic injection of human fibrin sealant in all 7 patients with intrathoracic anastomotic leakage, the volume of para-anastomotic drainage, CRP, and WBC count were improved compared with those before treatment. Relevant data were analyzed, and the differences were statistically significant (P = 0.019, P = 0.001, P = 0.014, respectively). No statistically significant difference was observed in the body temperature before and after treatment (P = 0.217). Conclusion For patients with intrathoracic anastomotic leakage after esophageal cancer surgery, endoscopic injection of human fibrin sealant to seal the anastomotic leakage has positive therapeutic effects of reducing exudation around the anastomotic leakage, reducing systemic inflammatory response, and improving clinical symptoms including dysphagia, weight loss without trying, chest pain, pressure or burning, worsening indigestion or heartburn and coughing or hoarseness. |
| first_indexed | 2024-12-13T08:05:26Z |
| format | Article |
| id | doaj.art-1927f4271cad49e59d583db596c69887 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-13T08:05:26Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-1927f4271cad49e59d583db596c698872022-12-21T23:54:20ZengBMCJournal of Cardiothoracic Surgery1749-80902020-05-011511610.1186/s13019-020-01127-wEndoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgeryXueyu Chen0Xiaoqin Yuan1Zhongyuan Chen2Lianggang Zhu3Department of Thoracic Surgery, Ruijin Hospital North, Shanghai Jiaotong University School of MedicineDepartment of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of MedicineDepartment of Thoracic Surgery, Ruijin Hospital North, Shanghai Jiaotong University School of MedicineDepartment of Thoracic Surgery, Ruijin Hospital North, Shanghai Jiaotong University School of MedicineAbstract Objective To investigate the application of endoscopic injection of human fibrin sealant in treatment of patients with intrathoracic anastomotic leakage after esophagectomy. Methods A total of 179 patients who underwent intrathoracic anastomosis after esophageal cancer surgery in our department From December 2012 to May 2015 were retrospectively analyzed. The clinical data and treatment of 7 patients with postoperative intrathoracic anastomotic leakage were analyzed and discussed. On Day 28 after operation, the 7 patients were given endoscopic injection of human fibrin sealant to seal the anastomotic leakage, and the changes in drainage volume, body temperature, CRP, white blood cell count and other indicators were compared before and after endoscopic intervention. Results After endoscopic injection of human fibrin sealant in all 7 patients with intrathoracic anastomotic leakage, the volume of para-anastomotic drainage, CRP, and WBC count were improved compared with those before treatment. Relevant data were analyzed, and the differences were statistically significant (P = 0.019, P = 0.001, P = 0.014, respectively). No statistically significant difference was observed in the body temperature before and after treatment (P = 0.217). Conclusion For patients with intrathoracic anastomotic leakage after esophageal cancer surgery, endoscopic injection of human fibrin sealant to seal the anastomotic leakage has positive therapeutic effects of reducing exudation around the anastomotic leakage, reducing systemic inflammatory response, and improving clinical symptoms including dysphagia, weight loss without trying, chest pain, pressure or burning, worsening indigestion or heartburn and coughing or hoarseness.http://link.springer.com/article/10.1186/s13019-020-01127-wEsophageal cancerAnastomotic leakageFibrin sealant |
| spellingShingle | Xueyu Chen Xiaoqin Yuan Zhongyuan Chen Lianggang Zhu Endoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgery Journal of Cardiothoracic Surgery Esophageal cancer Anastomotic leakage Fibrin sealant |
| title | Endoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgery |
| title_full | Endoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgery |
| title_fullStr | Endoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgery |
| title_full_unstemmed | Endoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgery |
| title_short | Endoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgery |
| title_sort | endoscopic injection of human fibrin sealant in treatment of intrathoracic anastomotic leakage after esophageal cancer surgery |
| topic | Esophageal cancer Anastomotic leakage Fibrin sealant |
| url | http://link.springer.com/article/10.1186/s13019-020-01127-w |
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