Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies
Advances in immunotherapy have brought significant therapeutic benefits to many cancer patients. Nonetheless, many cancer types are refractory to current immunotherapeutic approaches, meaning that further targets are required to increase the number of patients who benefit from these technologies. Pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/3/231 |
| _version_ | 1827354827896651776 |
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| author | Robert J. Salmond |
| author_facet | Robert J. Salmond |
| author_sort | Robert J. Salmond |
| collection | DOAJ |
| description | Advances in immunotherapy have brought significant therapeutic benefits to many cancer patients. Nonetheless, many cancer types are refractory to current immunotherapeutic approaches, meaning that further targets are required to increase the number of patients who benefit from these technologies. Protein tyrosine phosphatases (PTPs) have long been recognised to play a vital role in the regulation of cancer cell biology and the immune response. In this review, we summarize the evidence for both the pro-tumorigenic and tumour-suppressor function of non-receptor PTPs in cancer cells and discuss recent data showing that several of these enzymes act as intracellular immune checkpoints that suppress effective tumour immunity. We highlight new data showing that the deletion of inhibitory PTPs is a rational approach to improve the outcomes of adoptive T cell-based cancer immunotherapies and describe recent progress in the development of PTP inhibitors as anti-cancer drugs. |
| first_indexed | 2024-03-08T03:59:17Z |
| format | Article |
| id | doaj.art-1928387138264575864309430ec520eb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T03:59:17Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1928387138264575864309430ec520eb2024-02-09T15:09:39ZengMDPI AGCells2073-44092024-01-0113323110.3390/cells13030231Targeting Protein Tyrosine Phosphatases to Improve Cancer ImmunotherapiesRobert J. Salmond0Leeds Institute of Medical Research at St. James’s, School of Medicine, University of Leeds, Leeds LS9 7TF, UKAdvances in immunotherapy have brought significant therapeutic benefits to many cancer patients. Nonetheless, many cancer types are refractory to current immunotherapeutic approaches, meaning that further targets are required to increase the number of patients who benefit from these technologies. Protein tyrosine phosphatases (PTPs) have long been recognised to play a vital role in the regulation of cancer cell biology and the immune response. In this review, we summarize the evidence for both the pro-tumorigenic and tumour-suppressor function of non-receptor PTPs in cancer cells and discuss recent data showing that several of these enzymes act as intracellular immune checkpoints that suppress effective tumour immunity. We highlight new data showing that the deletion of inhibitory PTPs is a rational approach to improve the outcomes of adoptive T cell-based cancer immunotherapies and describe recent progress in the development of PTP inhibitors as anti-cancer drugs.https://www.mdpi.com/2073-4409/13/3/231protein tyrosine phosphatase (non-receptor type)cancer immunotherapytumour suppressoroncogeneT cellscell signalling |
| spellingShingle | Robert J. Salmond Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies Cells protein tyrosine phosphatase (non-receptor type) cancer immunotherapy tumour suppressor oncogene T cells cell signalling |
| title | Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies |
| title_full | Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies |
| title_fullStr | Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies |
| title_full_unstemmed | Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies |
| title_short | Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies |
| title_sort | targeting protein tyrosine phosphatases to improve cancer immunotherapies |
| topic | protein tyrosine phosphatase (non-receptor type) cancer immunotherapy tumour suppressor oncogene T cells cell signalling |
| url | https://www.mdpi.com/2073-4409/13/3/231 |
| work_keys_str_mv | AT robertjsalmond targetingproteintyrosinephosphatasestoimprovecancerimmunotherapies |