Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort
BackgroundSpontaneous abortion is one of the prevalent adverse reproductive outcomes, which seriously threatens maternal health around the world.ObjectiveThe current study is aimed to evaluate the association between maternal age and risk for spontaneous abortion among pregnant women in China.Method...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.933654/full |
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| author | Man Zhang Man Zhang Bo-Yi Yang Yongqing Sun Yongqing Sun Zhengmin Qian Pamela K. Xaverius Hannah E. Aaron Xiaoting Zhao Xiaoting Zhao Zheng Zhang Zheng Zhang Ruixia Liu Ruixia Liu Guang-Hui Dong Chenghong Yin Chenghong Yin Wentao Yue Wentao Yue |
| author_facet | Man Zhang Man Zhang Bo-Yi Yang Yongqing Sun Yongqing Sun Zhengmin Qian Pamela K. Xaverius Hannah E. Aaron Xiaoting Zhao Xiaoting Zhao Zheng Zhang Zheng Zhang Ruixia Liu Ruixia Liu Guang-Hui Dong Chenghong Yin Chenghong Yin Wentao Yue Wentao Yue |
| author_sort | Man Zhang |
| collection | DOAJ |
| description | BackgroundSpontaneous abortion is one of the prevalent adverse reproductive outcomes, which seriously threatens maternal health around the world.ObjectiveThe current study is aimed to evaluate the association between maternal age and risk for spontaneous abortion among pregnant women in China.MethodsThis was a case-control study based on the China Birth Cohort, we compared 338 cases ending in spontaneous abortion with 1,352 controls resulting in normal live births. The main exposure indicator and outcome indicator were maternal age and spontaneous abortion, respectively. We used both a generalized additive model and a two-piece-wise linear model to determine the association. We further performed stratified analyses to test the robustness of the association between maternal age and spontaneous abortion in different subgroups.ResultsWe observed a J-shaped relationship between maternal age and spontaneous abortion risk, after adjusting for multiple covariates. Further, we found that the optimal threshold age was 29.68 years old. The adjusted odds ratio (95% confidence interval) of spontaneous abortion per 1 year increase in maternal age were 0.97 (0.90–1.06) on the left side of the turning point and 1.25 (1.28–1.31) on the right side. Additionally, none of the covariates studied modified the association between maternal age and spontaneous abortion (P > 0.05).ConclusionsAdvanced maternal age (>30 years old) was significantly associated with increased prevalence of spontaneous abortion, supporting a J-shaped association between maternal age and spontaneous abortion. |
| first_indexed | 2024-04-13T04:43:57Z |
| format | Article |
| id | doaj.art-19288ba0f97a479ea070c61585ff2a34 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T04:43:57Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-19288ba0f97a479ea070c61585ff2a342022-12-22T03:01:55ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-07-011010.3389/fpubh.2022.933654933654Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth CohortMan Zhang0Man Zhang1Bo-Yi Yang2Yongqing Sun3Yongqing Sun4Zhengmin Qian5Pamela K. Xaverius6Hannah E. Aaron7Xiaoting Zhao8Xiaoting Zhao9Zheng Zhang10Zheng Zhang11Ruixia Liu12Ruixia Liu13Guang-Hui Dong14Chenghong Yin15Chenghong Yin16Wentao Yue17Wentao Yue18Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, ChinaBeijing Maternal and Child Health Care Hospital, Beijing, ChinaGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaBeijing Maternal and Child Health Care Hospital, Beijing, ChinaPrenatal Diagnosis Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, United StatesDepartment of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, United StatesDepartment of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, United StatesCentral Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, ChinaBeijing Maternal and Child Health Care Hospital, Beijing, ChinaBeijing Maternal and Child Health Care Hospital, Beijing, ChinaPrenatal Diagnosis Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, ChinaCentral Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, ChinaBeijing Maternal and Child Health Care Hospital, Beijing, ChinaGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaBeijing Maternal and Child Health Care Hospital, Beijing, ChinaPrenatal Diagnosis Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, ChinaCentral Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, ChinaBeijing Maternal and Child Health Care Hospital, Beijing, ChinaBackgroundSpontaneous abortion is one of the prevalent adverse reproductive outcomes, which seriously threatens maternal health around the world.ObjectiveThe current study is aimed to evaluate the association between maternal age and risk for spontaneous abortion among pregnant women in China.MethodsThis was a case-control study based on the China Birth Cohort, we compared 338 cases ending in spontaneous abortion with 1,352 controls resulting in normal live births. The main exposure indicator and outcome indicator were maternal age and spontaneous abortion, respectively. We used both a generalized additive model and a two-piece-wise linear model to determine the association. We further performed stratified analyses to test the robustness of the association between maternal age and spontaneous abortion in different subgroups.ResultsWe observed a J-shaped relationship between maternal age and spontaneous abortion risk, after adjusting for multiple covariates. Further, we found that the optimal threshold age was 29.68 years old. The adjusted odds ratio (95% confidence interval) of spontaneous abortion per 1 year increase in maternal age were 0.97 (0.90–1.06) on the left side of the turning point and 1.25 (1.28–1.31) on the right side. Additionally, none of the covariates studied modified the association between maternal age and spontaneous abortion (P > 0.05).ConclusionsAdvanced maternal age (>30 years old) was significantly associated with increased prevalence of spontaneous abortion, supporting a J-shaped association between maternal age and spontaneous abortion.https://www.frontiersin.org/articles/10.3389/fpubh.2022.933654/fullnon-linear relationshipmaternal agespontaneous abortioncase-controlChina Birth Cohort |
| spellingShingle | Man Zhang Man Zhang Bo-Yi Yang Yongqing Sun Yongqing Sun Zhengmin Qian Pamela K. Xaverius Hannah E. Aaron Xiaoting Zhao Xiaoting Zhao Zheng Zhang Zheng Zhang Ruixia Liu Ruixia Liu Guang-Hui Dong Chenghong Yin Chenghong Yin Wentao Yue Wentao Yue Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort Frontiers in Public Health non-linear relationship maternal age spontaneous abortion case-control China Birth Cohort |
| title | Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort |
| title_full | Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort |
| title_fullStr | Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort |
| title_full_unstemmed | Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort |
| title_short | Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort |
| title_sort | non linear relationship of maternal age with risk of spontaneous abortion a case control study in the china birth cohort |
| topic | non-linear relationship maternal age spontaneous abortion case-control China Birth Cohort |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.933654/full |
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