Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe pneumonia
Background Legionella species are important causative organisms of severe pneumonia. However, data are limited on predictors of progression to severe Legionella pneumonia (LP). Therefore, the risk factors for LP progression from non-severe to the severe form were investigated in the present study. M...
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| Format: | Article |
| Language: | English |
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Korean Society of Critical Care Medicine
2022-11-01
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| Series: | Acute and Critical Care |
| Subjects: | |
| Online Access: | http://www.accjournal.org/upload/pdf/acc-2022-00521.pdf |
| _version_ | 1811197579343429632 |
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| author | Jin-Young Huh Sang-Ho Choi Kyung-Wook Jo Jin Won Huh Sang-Bum Hong Tae Sun Shim Chae-Man Lim Younsuck Koh |
| author_facet | Jin-Young Huh Sang-Ho Choi Kyung-Wook Jo Jin Won Huh Sang-Bum Hong Tae Sun Shim Chae-Man Lim Younsuck Koh |
| author_sort | Jin-Young Huh |
| collection | DOAJ |
| description | Background Legionella species are important causative organisms of severe pneumonia. However, data are limited on predictors of progression to severe Legionella pneumonia (LP). Therefore, the risk factors for LP progression from non-severe to the severe form were investigated in the present study. Methods This was a retrospective cohort study that included adult LP patients admitted to a 2,700-bed referral center between January 2005 and December 2019. Results A total of 155 patients were identified during the study period; 58 patients (37.4%) initially presented with severe pneumonia and 97 (62.6%) patients with non-severe pneumonia. Among the 97 patients, 28 (28.9%) developed severe pneumonia during hospitalization and 69 patients (71.1%) recovered without progression to severe pneumonia. Multivariate logistic regression analysis showed platelet count ≤150,000/mm3 (odds ratio [OR], 2.923; 95% confidence interval [CI], 1.100–8.105; P=0.034) and delayed antibiotic treatment >1 day (OR, 3.092; 95% CI, 1.167–8.727; P=0.026) were significant independent factors associated with progression to severe pneumonia. Conclusions A low platelet count and delayed antibiotic treatment were significantly associated with the progression of non-severe LP to severe LP. |
| first_indexed | 2024-04-12T01:16:14Z |
| format | Article |
| id | doaj.art-1928eb2fa61349d2a9a48da49423c8f5 |
| institution | Directory Open Access Journal |
| issn | 2586-6052 2586-6060 |
| language | English |
| last_indexed | 2024-04-12T01:16:14Z |
| publishDate | 2022-11-01 |
| publisher | Korean Society of Critical Care Medicine |
| record_format | Article |
| series | Acute and Critical Care |
| spelling | doaj.art-1928eb2fa61349d2a9a48da49423c8f52022-12-22T03:53:56ZengKorean Society of Critical Care MedicineAcute and Critical Care2586-60522586-60602022-11-0137454354910.4266/acc.2022.005211420Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe pneumoniaJin-Young Huh0Sang-Ho Choi1Kyung-Wook Jo2Jin Won Huh3Sang-Bum Hong4Tae Sun Shim5Chae-Man Lim6Younsuck Koh7 Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Korea Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground Legionella species are important causative organisms of severe pneumonia. However, data are limited on predictors of progression to severe Legionella pneumonia (LP). Therefore, the risk factors for LP progression from non-severe to the severe form were investigated in the present study. Methods This was a retrospective cohort study that included adult LP patients admitted to a 2,700-bed referral center between January 2005 and December 2019. Results A total of 155 patients were identified during the study period; 58 patients (37.4%) initially presented with severe pneumonia and 97 (62.6%) patients with non-severe pneumonia. Among the 97 patients, 28 (28.9%) developed severe pneumonia during hospitalization and 69 patients (71.1%) recovered without progression to severe pneumonia. Multivariate logistic regression analysis showed platelet count ≤150,000/mm3 (odds ratio [OR], 2.923; 95% confidence interval [CI], 1.100–8.105; P=0.034) and delayed antibiotic treatment >1 day (OR, 3.092; 95% CI, 1.167–8.727; P=0.026) were significant independent factors associated with progression to severe pneumonia. Conclusions A low platelet count and delayed antibiotic treatment were significantly associated with the progression of non-severe LP to severe LP.http://www.accjournal.org/upload/pdf/acc-2022-00521.pdfantibioticspneumoniaprognosisthrombocytopenia |
| spellingShingle | Jin-Young Huh Sang-Ho Choi Kyung-Wook Jo Jin Won Huh Sang-Bum Hong Tae Sun Shim Chae-Man Lim Younsuck Koh Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe pneumonia Acute and Critical Care antibiotics pneumonia prognosis thrombocytopenia |
| title | Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe pneumonia |
| title_full | Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe pneumonia |
| title_fullStr | Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe pneumonia |
| title_full_unstemmed | Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe pneumonia |
| title_short | Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe pneumonia |
| title_sort | incidence and risk factors associated with progression to severe pneumonia among adults with non severe pneumonia |
| topic | antibiotics pneumonia prognosis thrombocytopenia |
| url | http://www.accjournal.org/upload/pdf/acc-2022-00521.pdf |
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