Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data
Background: Perfluorooctanoic acid (PFOA) is detected in the blood of virtually all biomonitoring study participants. Assessing health risks associated with blood PFOA levels is challenging because exposure guidance values (EGVs) are typically expressed in terms of external dose. Biomonitoring equiv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412023004439 |
| _version_ | 1797683184692887552 |
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| author | Ernest-Louli Tewfik Nolwenn Noisel Marc-André Verner |
| author_facet | Ernest-Louli Tewfik Nolwenn Noisel Marc-André Verner |
| author_sort | Ernest-Louli Tewfik |
| collection | DOAJ |
| description | Background: Perfluorooctanoic acid (PFOA) is detected in the blood of virtually all biomonitoring study participants. Assessing health risks associated with blood PFOA levels is challenging because exposure guidance values (EGVs) are typically expressed in terms of external dose. Biomonitoring equivalents (BEs) consistent with EGVs could facilitate health-based interpretations. Objective: To i) derive BEs for serum/plasma PFOA corresponding to non-cancer EGVs of the U.S. Environmental Protection Agency (U.S. EPA), the Agency for Toxic Substances and Disease Registry (ATSDR) and Health Canada, and ii) compare with PFOA concentrations from national biomonitoring surveys. Methods: Starting from EGV points of departure, we employed pharmacokinetic data/models and uncertainty factors. Points of departure in pregnant rodents (U.S. EPA 2016, ATSDR) were converted into fetus and pup serum concentrations using an animal gestation/lactation pharmacokinetic model, and equivalent human fetus and child concentrations were converted into BEs in maternal serum using a human gestation/lactation model. The point of departure in adult rodents (Health Canada) was converted into a BE using experimental data. For epidemiology-based EGVs (U.S. EPA 2023, draft), BEs were directly based on epidemiological data or derived using a human gestation/lactation pharmacokinetic model. BEs were compared with Canadian/U.S. biomonitoring data. Results: Non-cancer BEs (ng/mL) were 684 (Health Canada, 2018) or ranged from 15 to 29 (U.S. EPA, 2016), 6–10 (ATSDR, 2021) and 0.2–0.8 (U.S. EPA, 2023, draft). Ninety-fifth percentiles of serum levels from the 2018–2019 Canadian Health Measures Survey (CHMS) and the 2017–2018 National Health and Nutrition Examination Survey (NHANES) were slightly below the BE for ATSDR, and geometric means were above the non-cancer BEs for the U.S. EPA (2023, draft). Conclusion: Non-cancer BEs spanned three orders of magnitude. The lowest BEs were for EGVs based on developmental endpoints in epidemiological studies. Concentrations in Canadian/U.S. national surveys were higher than or close to BEs for the most recent non-cancer EGVs. |
| first_indexed | 2024-03-12T00:10:51Z |
| format | Article |
| id | doaj.art-192a9aa0c7b64d2ca2e9fded153bdcd3 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-03-12T00:10:51Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-192a9aa0c7b64d2ca2e9fded153bdcd32023-09-16T05:28:45ZengElsevierEnvironment International0160-41202023-09-01179108170Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring dataErnest-Louli Tewfik0Nolwenn Noisel1Marc-André Verner2Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, Montreal, Canada; Centre de Recherche en Santé Publique, Université de Montréal and CIUSSS du Centre-Sud-de-l’Île-de-Montréal, CanadaDepartment of Occupational and Environmental Health, School of Public Health, Université de Montréal, Montreal, Canada; Centre de Recherche en Santé Publique, Université de Montréal and CIUSSS du Centre-Sud-de-l’Île-de-Montréal, CanadaDepartment of Occupational and Environmental Health, School of Public Health, Université de Montréal, Montreal, Canada; Centre de Recherche en Santé Publique, Université de Montréal and CIUSSS du Centre-Sud-de-l’Île-de-Montréal, Canada; Corresponding author at: Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, 2375 chemin de la Côte-Sainte-Catherine, office 4105, Montreal, QC H3T 1A8, Canada.Background: Perfluorooctanoic acid (PFOA) is detected in the blood of virtually all biomonitoring study participants. Assessing health risks associated with blood PFOA levels is challenging because exposure guidance values (EGVs) are typically expressed in terms of external dose. Biomonitoring equivalents (BEs) consistent with EGVs could facilitate health-based interpretations. Objective: To i) derive BEs for serum/plasma PFOA corresponding to non-cancer EGVs of the U.S. Environmental Protection Agency (U.S. EPA), the Agency for Toxic Substances and Disease Registry (ATSDR) and Health Canada, and ii) compare with PFOA concentrations from national biomonitoring surveys. Methods: Starting from EGV points of departure, we employed pharmacokinetic data/models and uncertainty factors. Points of departure in pregnant rodents (U.S. EPA 2016, ATSDR) were converted into fetus and pup serum concentrations using an animal gestation/lactation pharmacokinetic model, and equivalent human fetus and child concentrations were converted into BEs in maternal serum using a human gestation/lactation model. The point of departure in adult rodents (Health Canada) was converted into a BE using experimental data. For epidemiology-based EGVs (U.S. EPA 2023, draft), BEs were directly based on epidemiological data or derived using a human gestation/lactation pharmacokinetic model. BEs were compared with Canadian/U.S. biomonitoring data. Results: Non-cancer BEs (ng/mL) were 684 (Health Canada, 2018) or ranged from 15 to 29 (U.S. EPA, 2016), 6–10 (ATSDR, 2021) and 0.2–0.8 (U.S. EPA, 2023, draft). Ninety-fifth percentiles of serum levels from the 2018–2019 Canadian Health Measures Survey (CHMS) and the 2017–2018 National Health and Nutrition Examination Survey (NHANES) were slightly below the BE for ATSDR, and geometric means were above the non-cancer BEs for the U.S. EPA (2023, draft). Conclusion: Non-cancer BEs spanned three orders of magnitude. The lowest BEs were for EGVs based on developmental endpoints in epidemiological studies. Concentrations in Canadian/U.S. national surveys were higher than or close to BEs for the most recent non-cancer EGVs.http://www.sciencedirect.com/science/article/pii/S0160412023004439Perfluorooctanoic acid (PFOA)Biomonitoring equivalentsPharmacokinetic modeling |
| spellingShingle | Ernest-Louli Tewfik Nolwenn Noisel Marc-André Verner Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data Environment International Perfluorooctanoic acid (PFOA) Biomonitoring equivalents Pharmacokinetic modeling |
| title | Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data |
| title_full | Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data |
| title_fullStr | Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data |
| title_full_unstemmed | Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data |
| title_short | Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data |
| title_sort | biomonitoring equivalents for perfluorooctanoic acid pfoa for the interpretation of biomonitoring data |
| topic | Perfluorooctanoic acid (PFOA) Biomonitoring equivalents Pharmacokinetic modeling |
| url | http://www.sciencedirect.com/science/article/pii/S0160412023004439 |
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