A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague

A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague

Mice were immunized with a combination of self-amplifying (sa) RNA constructs for the F1 and V antigens of Yersinia pestis at a dose level of 1 μg or 5 μg or with the respective protein sub-units as a reference vaccine. The immunization of outbred OF1 mice on day 0 and day 28 with the lowest dose us...

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Bibliographic Details
Main Authors: Robin John Shattock, Voahangy Andrianaivoarimanana, Paul F. McKay, Lovasoa Nomena Randriantseheno, Valarmathy Murugaiah, K. Samnuan, Paul Rogers, John S. Tregoning, Minoarisoa Rajerison, Kristoffer M. Moore, Thomas Robert Laws, E. Diane Williamson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Microbiology
Subjects:
saRNA
mRNA
vaccine
plague
efficacy
mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1247041/full

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