FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells

FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells

FBW7 functions as a tumor suppressor by targeting oncoproteins for degradation. Our previous study found FBW7 was low expressed in pancreatic cancer due to sustained activation of Ras-Raf-MEK-ERK pathway, which destabilized FBW7 by phosphorylating at Thr205. MicroPET/CT imaging results revealed that...

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Bibliographic Details
Main Authors: Zeng Ye, Qifeng Zhuo, Qiangsheng Hu, Xiaowu Xu, Mengqi liu, Zheng Zhang, Wenyan Xu, Wensheng Liu, Guixiong Fan, Yi Qin, Xianjun Yu, Shunrong Ji
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
Pancreatic cancer
FBW7
Apoptosis
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720310120

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