Light-Mediated Transformation of Renieramycins and Semisynthesis of 4′-Pyridinecarbonyl-Substituted Renieramycin-Type Derivatives as Potential Cytotoxic Agents against Non-Small-Cell Lung Cancer Cells

Light-Mediated Transformation of Renieramycins and Semisynthesis of 4′-Pyridinecarbonyl-Substituted Renieramycin-Type Derivatives as Potential Cytotoxic Agents against Non-Small-Cell Lung Cancer Cells

The semisynthesis of renieramycin-type derivatives was achieved under mild and facile conditions by attaching a 1,3-dioxole-bridged phenolic moiety onto ring A of the renieramycin structure and adding a 4′-pyridinecarbonyl ester substituent at its C-5 or C-22 position. These were accomplished throug...

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Bibliographic Details
Main Authors: Suwimon Sinsook, Koonchira Buaban, Iksen Iksen, Korrakod Petsri, Bhurichaya Innets, Chaisak Chansriniyom, Khanit Suwanborirux, Masashi Yokoya, Naoki Saito, Varisa Pongrakhananon, Pithi Chanvorachote, Supakarn Chamni
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Marine Drugs
Subjects:
<i>Xestospongia</i> sp.
cytotoxicity
renieramycins
semisynthesis
light-induced intramolecular photoredox reaction
non-small-cell lung cancer
Online Access:https://www.mdpi.com/1660-3397/21/7/400

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https://www.mdpi.com/1660-3397/21/7/400

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