Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that can induce systemic inflammation. Ultraviolet-A and X-ray irradiation have been reported to have therapeutic effects in patients with SLE. We previously demonstrated that CD180-n...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2023/9969079 |
| _version_ | 1797649692308275200 |
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| author | Kazuko Fujita Taku Kuwabara Bing Wang Kaoru Tanaka Kei Ito Yuri Akishima-Fukasawa Tetuo Mikami Yoshikiyo Akasaka Toshiharu Ishii |
| author_facet | Kazuko Fujita Taku Kuwabara Bing Wang Kaoru Tanaka Kei Ito Yuri Akishima-Fukasawa Tetuo Mikami Yoshikiyo Akasaka Toshiharu Ishii |
| author_sort | Kazuko Fujita |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that can induce systemic inflammation. Ultraviolet-A and X-ray irradiation have been reported to have therapeutic effects in patients with SLE. We previously demonstrated that CD180-negative cells, these are radiosensitive, contribute to the development of SLE-like morbidity in NZBWF1 mice. In this study, the effects of irradiation on SLE-like morbidity manifestations in NZBWF1 mice and on CD180-negative cells were investigated. Whole-body irradiation, excluding the head, attenuated SLE-like morbidity in vivo, as indicated by the prevention of the renal lesion development, inhibition of anti-dsDNA antibody production, reduction of urinary protein levels, and prolongation of the lifespan. Irradiation also reduced the proportion of CD180-negative cells in the spleen. Although other immune cells or molecules may be triggered because of the whole-body irradiation treatment, previous research, and the current results suggest a strong relationship between the radiation-induced decrease in CD180-negative cells and the amelioration of SLE-like morbidities. Clinical trials assessing CD180-negative cells as a therapeutic target for SLE have been hampered by the lack of validated cell markers; nonetheless, the present findings suggest that radiotherapy may be a new therapeutic strategy for managing SLE symptoms. |
| first_indexed | 2024-03-11T15:50:38Z |
| format | Article |
| id | doaj.art-19308e1fd24740329f417b4f86089ef4 |
| institution | Directory Open Access Journal |
| issn | 2314-7156 |
| language | English |
| last_indexed | 2024-03-11T15:50:38Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj.art-19308e1fd24740329f417b4f86089ef42023-10-26T00:00:02ZengHindawi LimitedJournal of Immunology Research2314-71562023-01-01202310.1155/2023/9969079Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative CellsKazuko Fujita0Taku Kuwabara1Bing Wang2Kaoru Tanaka3Kei Ito4Yuri Akishima-Fukasawa5Tetuo Mikami6Yoshikiyo Akasaka7Toshiharu Ishii8Department of PathologyDepartment of Molecular ImmunologyInstitute for Radiological ScienceInstitute for Radiological ScienceDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologySystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that can induce systemic inflammation. Ultraviolet-A and X-ray irradiation have been reported to have therapeutic effects in patients with SLE. We previously demonstrated that CD180-negative cells, these are radiosensitive, contribute to the development of SLE-like morbidity in NZBWF1 mice. In this study, the effects of irradiation on SLE-like morbidity manifestations in NZBWF1 mice and on CD180-negative cells were investigated. Whole-body irradiation, excluding the head, attenuated SLE-like morbidity in vivo, as indicated by the prevention of the renal lesion development, inhibition of anti-dsDNA antibody production, reduction of urinary protein levels, and prolongation of the lifespan. Irradiation also reduced the proportion of CD180-negative cells in the spleen. Although other immune cells or molecules may be triggered because of the whole-body irradiation treatment, previous research, and the current results suggest a strong relationship between the radiation-induced decrease in CD180-negative cells and the amelioration of SLE-like morbidities. Clinical trials assessing CD180-negative cells as a therapeutic target for SLE have been hampered by the lack of validated cell markers; nonetheless, the present findings suggest that radiotherapy may be a new therapeutic strategy for managing SLE symptoms.http://dx.doi.org/10.1155/2023/9969079 |
| spellingShingle | Kazuko Fujita Taku Kuwabara Bing Wang Kaoru Tanaka Kei Ito Yuri Akishima-Fukasawa Tetuo Mikami Yoshikiyo Akasaka Toshiharu Ishii Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells Journal of Immunology Research |
| title | Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells |
| title_full | Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells |
| title_fullStr | Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells |
| title_full_unstemmed | Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells |
| title_short | Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells |
| title_sort | irradiation attenuates systemic lupus erythematosus like morbidity in nzbwf1 mice focusing on cd180 negative cells |
| url | http://dx.doi.org/10.1155/2023/9969079 |
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