The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
Fasil Getu,1 Melak Aynalem,2 Segenet Bizuneh,3 Bamlaku Enawgaw2 1Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicin...
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| Format: | Article |
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Dove Medical Press
2022-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/the-prevalence-of-coagulopathy-and-associated-factors-among-adult-type-peer-reviewed-fulltext-article-DMSO |
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| author | Getu F Aynalem M Bizuneh S Enawgaw B |
| author_facet | Getu F Aynalem M Bizuneh S Enawgaw B |
| author_sort | Getu F |
| collection | DOAJ |
| description | Fasil Getu,1 Melak Aynalem,2 Segenet Bizuneh,3 Bamlaku Enawgaw2 1Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Fasil Getu, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Jigjiga University, PO Box 1020, Jigjiga, Ethiopia, Tel +251 927436332, Email fasilgetu85@gmail.comIntroduction: Diabetes mellitus is a heterogeneous disorder of metabolism which results hyperglycemic-related atherothrombotic complications. These complications are the leading cause of death in diabetes mellitus patients. Therefore, this study was aimed to determine the prevalence of coagulopathy and associated factors among adult type II diabetes mellitus patients attending at University of Gondar comprehensive specialized hospital.Methods: A facility-based cross-sectional study was conducted among 357 study participants. A questionnaire and a data collection sheet were used to collect the sociodemographic and clinical data, respectively. About 6mL of venous blood samples were collected for coagulation tests and complete blood count. For prolonged coagulation tests, a mixing test was performed. Data were entered into EpiInfo and exported to SPSS for statistical analysis. Then, descriptive statistics were done. A binary and multivariable logistic regression model was used to identify the associated factors. P-value < 0.05 was considered as statistically significant.Results: In this study, 357 study participants were included. Of them, 52.1% (186) and 80.7% (288) were females and urban residences, respectively. The prevalence of coagulopathy was 26.6% (95% CI: 22.1, 31.5%). Out of this, 12.3% and 8.7% showed shortened PT and aPTT, respectively. In addition, the prevalence of prolonged PT and aPTT were 5.6% and 3.9%, respectively. From the prolonged PT and aPTT, the prevalence of factor deficiency was 95% and 92.8%, respectively. Being female (AOR = 2.06; 95% CI: 1.11– 3.85%), abnormal BMI (AOR = 1.94; 95% CI: 1.08– 3.50), and educational status of high school (AOR = 0.26; 95% CI: 0.10– 0.83%) were significantly associated with hypercoagulation.Conclusion: Coagulopathy is an important public health problem among type II diabetes mellitus patients. Being female and having abnormal BMI were associated with hypercoagulation. Therefore, regular monitoring of coagulation parameters is vital to reduce the consequence of coagulopathy.Keywords: coagulopathy, mixing study, type II diabetes mellitus, Gondar, Ethiopia |
| first_indexed | 2024-04-10T18:30:39Z |
| format | Article |
| id | doaj.art-19344beec25f4396acf4cdb705fdc282 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:30:39Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-19344beec25f4396acf4cdb705fdc2822023-02-02T04:06:04ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-02-01Volume 1557959073202The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest EthiopiaGetu FAynalem MBizuneh SEnawgaw BFasil Getu,1 Melak Aynalem,2 Segenet Bizuneh,3 Bamlaku Enawgaw2 1Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Fasil Getu, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Jigjiga University, PO Box 1020, Jigjiga, Ethiopia, Tel +251 927436332, Email fasilgetu85@gmail.comIntroduction: Diabetes mellitus is a heterogeneous disorder of metabolism which results hyperglycemic-related atherothrombotic complications. These complications are the leading cause of death in diabetes mellitus patients. Therefore, this study was aimed to determine the prevalence of coagulopathy and associated factors among adult type II diabetes mellitus patients attending at University of Gondar comprehensive specialized hospital.Methods: A facility-based cross-sectional study was conducted among 357 study participants. A questionnaire and a data collection sheet were used to collect the sociodemographic and clinical data, respectively. About 6mL of venous blood samples were collected for coagulation tests and complete blood count. For prolonged coagulation tests, a mixing test was performed. Data were entered into EpiInfo and exported to SPSS for statistical analysis. Then, descriptive statistics were done. A binary and multivariable logistic regression model was used to identify the associated factors. P-value < 0.05 was considered as statistically significant.Results: In this study, 357 study participants were included. Of them, 52.1% (186) and 80.7% (288) were females and urban residences, respectively. The prevalence of coagulopathy was 26.6% (95% CI: 22.1, 31.5%). Out of this, 12.3% and 8.7% showed shortened PT and aPTT, respectively. In addition, the prevalence of prolonged PT and aPTT were 5.6% and 3.9%, respectively. From the prolonged PT and aPTT, the prevalence of factor deficiency was 95% and 92.8%, respectively. Being female (AOR = 2.06; 95% CI: 1.11– 3.85%), abnormal BMI (AOR = 1.94; 95% CI: 1.08– 3.50), and educational status of high school (AOR = 0.26; 95% CI: 0.10– 0.83%) were significantly associated with hypercoagulation.Conclusion: Coagulopathy is an important public health problem among type II diabetes mellitus patients. Being female and having abnormal BMI were associated with hypercoagulation. Therefore, regular monitoring of coagulation parameters is vital to reduce the consequence of coagulopathy.Keywords: coagulopathy, mixing study, type II diabetes mellitus, Gondar, Ethiopiahttps://www.dovepress.com/the-prevalence-of-coagulopathy-and-associated-factors-among-adult-type-peer-reviewed-fulltext-article-DMSOcoagulopathymixing studytype ii diabetes mellitusgondarand ethiopia |
| spellingShingle | Getu F Aynalem M Bizuneh S Enawgaw B The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia Diabetes, Metabolic Syndrome and Obesity coagulopathy mixing study type ii diabetes mellitus gondar and ethiopia |
| title | The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_full | The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_fullStr | The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_full_unstemmed | The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_short | The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_sort | prevalence of coagulopathy and associated factors among adult type ii diabetes mellitus patients attending the university of gondar comprehensive specialized hospital northwest ethiopia |
| topic | coagulopathy mixing study type ii diabetes mellitus gondar and ethiopia |
| url | https://www.dovepress.com/the-prevalence-of-coagulopathy-and-associated-factors-among-adult-type-peer-reviewed-fulltext-article-DMSO |
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