Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer
Objectives To explore the effect of combined hematological and physical measurement indicators on the prognosis of patients undergoing surgery for gastric or colorectal cancer and to screen for the best prognostic indicators. Introduction Gastric and colorectal cancer is a widespread health concern...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-01-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748241230888 |
| _version_ | 1827364058522714112 |
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| author | Xin Zheng Jin-Yu Shi Zi-Wen Wang Guo-Tian Ruan Yi-Zhong Ge Shi-Qi Lin Chen-An Liu Yue Chen Hai-Lun Xie Meng-Meng Song Tong Liu Ming Yang Xiao-Yue Liu Li Deng Ming-Hua Cong Han-Ping Shi |
| author_facet | Xin Zheng Jin-Yu Shi Zi-Wen Wang Guo-Tian Ruan Yi-Zhong Ge Shi-Qi Lin Chen-An Liu Yue Chen Hai-Lun Xie Meng-Meng Song Tong Liu Ming Yang Xiao-Yue Liu Li Deng Ming-Hua Cong Han-Ping Shi |
| author_sort | Xin Zheng |
| collection | DOAJ |
| description | Objectives To explore the effect of combined hematological and physical measurement indicators on the prognosis of patients undergoing surgery for gastric or colorectal cancer and to screen for the best prognostic indicators. Introduction Gastric and colorectal cancer is a widespread health concern worldwide and one of the major contributors to cancer-related death. The hematological and physical measurement indicators have been shown to associate with the prognosis of patients undergoing surgery for gastric or colorectal cancer, respectively, but it is still unclear whether the combination of the two can reflect the prognosis more effectively. Methods Thirteen hematological indicators and 5 physical measurement indicators were selected in this study, and the most promising ones were screened using LASSO regression. Then, the best prognostic indicators were selected by time-ROC curves. Survival curves were constructed using the Kaplan–Meier method, and the effects of hematological and physical measurement indicators on the prognosis of patients undergoing surgery for gastric or colorectal cancers were evaluated by Cox proportional risk regression analysis. In addition, the relationship between hematological and physical measurement indicators on secondary outcomes, including length of stay, hospitalization costs, intensive care unit (ICU) admission, and patients’ subjective global assessment scores (PGSGA), was explored. Results After initial screening, among the hematological indicators, the geriatric nutritional risk index (GNRI) showed the highest mean area under the curve (AUC) values. Among body measures, calf circumference (CC) showed the highest mean AUC value. Further analyses showed that the combination of combined nutritional prognostic index (GNRI) and calf circumference (CC) (GNRI-CC) had the best performance in predicting the prognosis of patients undergoing surgery for gastric or colorectal cancers. Low GNRI, low CC, and low GNRI-low CC increased the risk of death by 44%, 48%, and 104%, respectively. Sensitivity analyses showed the same trend. In addition, low GNRI-low CC increased the risk of malnutrition by 17%. Conclusion This study emphasizes that a combination of blood measures and body measures is essential to accurately assess the prognosis of patients undergoing surgery for gastric or colorectal cancers. The GNRI-CC is a good prognostic indicator and can also assess the risk of possible malnutrition. |
| first_indexed | 2024-03-08T08:01:18Z |
| format | Article |
| id | doaj.art-1934ca6e37d44f8cab0c8e309f9f89ad |
| institution | Directory Open Access Journal |
| issn | 1526-2359 |
| language | English |
| last_indexed | 2024-03-08T08:01:18Z |
| publishDate | 2024-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-1934ca6e37d44f8cab0c8e309f9f89ad2024-02-02T12:03:43ZengSAGE PublishingCancer Control1526-23592024-01-013110.1177/10732748241230888Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal CancerXin ZhengJin-Yu ShiZi-Wen WangGuo-Tian RuanYi-Zhong GeShi-Qi LinChen-An LiuYue ChenHai-Lun XieMeng-Meng SongTong LiuMing YangXiao-Yue LiuLi DengMing-Hua CongHan-Ping ShiObjectives To explore the effect of combined hematological and physical measurement indicators on the prognosis of patients undergoing surgery for gastric or colorectal cancer and to screen for the best prognostic indicators. Introduction Gastric and colorectal cancer is a widespread health concern worldwide and one of the major contributors to cancer-related death. The hematological and physical measurement indicators have been shown to associate with the prognosis of patients undergoing surgery for gastric or colorectal cancer, respectively, but it is still unclear whether the combination of the two can reflect the prognosis more effectively. Methods Thirteen hematological indicators and 5 physical measurement indicators were selected in this study, and the most promising ones were screened using LASSO regression. Then, the best prognostic indicators were selected by time-ROC curves. Survival curves were constructed using the Kaplan–Meier method, and the effects of hematological and physical measurement indicators on the prognosis of patients undergoing surgery for gastric or colorectal cancers were evaluated by Cox proportional risk regression analysis. In addition, the relationship between hematological and physical measurement indicators on secondary outcomes, including length of stay, hospitalization costs, intensive care unit (ICU) admission, and patients’ subjective global assessment scores (PGSGA), was explored. Results After initial screening, among the hematological indicators, the geriatric nutritional risk index (GNRI) showed the highest mean area under the curve (AUC) values. Among body measures, calf circumference (CC) showed the highest mean AUC value. Further analyses showed that the combination of combined nutritional prognostic index (GNRI) and calf circumference (CC) (GNRI-CC) had the best performance in predicting the prognosis of patients undergoing surgery for gastric or colorectal cancers. Low GNRI, low CC, and low GNRI-low CC increased the risk of death by 44%, 48%, and 104%, respectively. Sensitivity analyses showed the same trend. In addition, low GNRI-low CC increased the risk of malnutrition by 17%. Conclusion This study emphasizes that a combination of blood measures and body measures is essential to accurately assess the prognosis of patients undergoing surgery for gastric or colorectal cancers. The GNRI-CC is a good prognostic indicator and can also assess the risk of possible malnutrition.https://doi.org/10.1177/10732748241230888 |
| spellingShingle | Xin Zheng Jin-Yu Shi Zi-Wen Wang Guo-Tian Ruan Yi-Zhong Ge Shi-Qi Lin Chen-An Liu Yue Chen Hai-Lun Xie Meng-Meng Song Tong Liu Ming Yang Xiao-Yue Liu Li Deng Ming-Hua Cong Han-Ping Shi Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer Cancer Control |
| title | Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer |
| title_full | Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer |
| title_fullStr | Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer |
| title_full_unstemmed | Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer |
| title_short | Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer |
| title_sort | geriatric nutritional risk index combined with calf circumference can be a good predictor of prognosis in patients undergoing surgery for gastric or colorectal cancer |
| url | https://doi.org/10.1177/10732748241230888 |
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