Eosinophils: A Friend or Foe in human health and diseases
Since their discovery, around 150 years, eosinophils research has been a field of changing perspective, and new directions are emerging since then. Initially, eosinophils were perceived as terminally-differentiated cytotoxic effector cells. Clearly, eosinophils are capable of playing functions other...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2022-11-01
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| Series: | Kidney Diseases |
| Online Access: | https://www.karger.com/Article/FullText/528156 |
| _version_ | 1811177724311502848 |
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| author | Madiha Zahra Syeda Tu Hong Chao Zhang Songmin Ying Huahao Shen |
| author_facet | Madiha Zahra Syeda Tu Hong Chao Zhang Songmin Ying Huahao Shen |
| author_sort | Madiha Zahra Syeda |
| collection | DOAJ |
| description | Since their discovery, around 150 years, eosinophils research has been a field of changing perspective, and new directions are emerging since then. Initially, eosinophils were perceived as terminally-differentiated cytotoxic effector cells. Clearly, eosinophils are capable of playing functions other than immune responses, which is not surprising given their intricate interactions with pathogens as well as other circulating leukocytes. Attempts to comprehend the eosinophil biology and functions have yielded remarkable insights into their roles in human health and sickness. The use of FDA approved eosinophils-targeting biologics has provided exciting opportunities to directly explore the contributions of eosinophils in disease etiology in humans. In this review we will focus on the eosinophils’ lifecycle, and discuss the current state of knowledge from mouse models and retrospective human studies demonstrating eosinophils’ roles in the pathogenesis of human diseases such as asthma, cancer, and kidney disorders. Despite three recently approved anti-eosinophil agents, a number of key questions and challenges remain far from settled, thereby generating opportunity to further explore this enigmatic cell. A comprehensive understanding of eosinophils biology and function will surely aid in developing improved therapeutic strategies against eosinophils-associated disorders. |
| first_indexed | 2024-04-11T06:07:12Z |
| format | Article |
| id | doaj.art-19353c0835f74886bbad4e09ae0d1e21 |
| institution | Directory Open Access Journal |
| issn | 2296-9381 2296-9357 |
| language | English |
| last_indexed | 2024-04-11T06:07:12Z |
| publishDate | 2022-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney Diseases |
| spelling | doaj.art-19353c0835f74886bbad4e09ae0d1e212022-12-22T04:41:28ZengKarger PublishersKidney Diseases2296-93812296-93572022-11-0110.1159/000528156528156Eosinophils: A Friend or Foe in human health and diseasesMadiha Zahra SyedaTu HongChao ZhangSongmin YingHuahao ShenSince their discovery, around 150 years, eosinophils research has been a field of changing perspective, and new directions are emerging since then. Initially, eosinophils were perceived as terminally-differentiated cytotoxic effector cells. Clearly, eosinophils are capable of playing functions other than immune responses, which is not surprising given their intricate interactions with pathogens as well as other circulating leukocytes. Attempts to comprehend the eosinophil biology and functions have yielded remarkable insights into their roles in human health and sickness. The use of FDA approved eosinophils-targeting biologics has provided exciting opportunities to directly explore the contributions of eosinophils in disease etiology in humans. In this review we will focus on the eosinophils’ lifecycle, and discuss the current state of knowledge from mouse models and retrospective human studies demonstrating eosinophils’ roles in the pathogenesis of human diseases such as asthma, cancer, and kidney disorders. Despite three recently approved anti-eosinophil agents, a number of key questions and challenges remain far from settled, thereby generating opportunity to further explore this enigmatic cell. A comprehensive understanding of eosinophils biology and function will surely aid in developing improved therapeutic strategies against eosinophils-associated disorders.https://www.karger.com/Article/FullText/528156 |
| spellingShingle | Madiha Zahra Syeda Tu Hong Chao Zhang Songmin Ying Huahao Shen Eosinophils: A Friend or Foe in human health and diseases Kidney Diseases |
| title | Eosinophils: A Friend or Foe in human health and diseases |
| title_full | Eosinophils: A Friend or Foe in human health and diseases |
| title_fullStr | Eosinophils: A Friend or Foe in human health and diseases |
| title_full_unstemmed | Eosinophils: A Friend or Foe in human health and diseases |
| title_short | Eosinophils: A Friend or Foe in human health and diseases |
| title_sort | eosinophils a friend or foe in human health and diseases |
| url | https://www.karger.com/Article/FullText/528156 |
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