Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition
The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FF...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-01-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/50601 |
| _version_ | 1811236794654523392 |
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| author | E Mae Guthman Joshua D Garcia Ming Ma Philip Chu Serapio M Baca Katharine R Smith Diego Restrepo Molly M Huntsman |
| author_facet | E Mae Guthman Joshua D Garcia Ming Ma Philip Chu Serapio M Baca Katharine R Smith Diego Restrepo Molly M Huntsman |
| author_sort | E Mae Guthman |
| collection | DOAJ |
| description | The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FFI). Despite literature implicating parvalbumin expressing (PV+) INs in FFI in cortex and hippocampus, prior anatomical experiments in BLA implicate somatostatin expressing (Sst+) INs. The lateral entorhinal cortex (LEC) projects to BLA where it drives FFI. In the present study, we explored the role of interneurons in this circuit. Using mice, we combined patch clamp electrophysiology, chemogenetics, unsupervised cluster analysis, and predictive modeling and found that a previously unreported subpopulation of fast-spiking Sst+ INs mediate LEC→BLA FFI. |
| first_indexed | 2024-04-12T12:14:14Z |
| format | Article |
| id | doaj.art-1935d86d414344138ff9d6dc3c140a8b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:14:14Z |
| publishDate | 2020-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1935d86d414344138ff9d6dc3c140a8b2022-12-22T03:33:28ZengeLife Sciences Publications LtdeLife2050-084X2020-01-01910.7554/eLife.50601Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibitionE Mae Guthman0https://orcid.org/0000-0002-2190-7520Joshua D Garcia1Ming Ma2Philip Chu3Serapio M Baca4Katharine R Smith5Diego Restrepo6https://orcid.org/0000-0002-4972-446XMolly M Huntsman7https://orcid.org/0000-0002-5954-0023Neuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, United States; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, United States; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, United States; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, United StatesNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, United StatesNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, United States; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, United States; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, United StatesThe basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FFI). Despite literature implicating parvalbumin expressing (PV+) INs in FFI in cortex and hippocampus, prior anatomical experiments in BLA implicate somatostatin expressing (Sst+) INs. The lateral entorhinal cortex (LEC) projects to BLA where it drives FFI. In the present study, we explored the role of interneurons in this circuit. Using mice, we combined patch clamp electrophysiology, chemogenetics, unsupervised cluster analysis, and predictive modeling and found that a previously unreported subpopulation of fast-spiking Sst+ INs mediate LEC→BLA FFI.https://elifesciences.org/articles/50601inhibitionplasticityamygdalasomatostatinparvalbumin |
| spellingShingle | E Mae Guthman Joshua D Garcia Ming Ma Philip Chu Serapio M Baca Katharine R Smith Diego Restrepo Molly M Huntsman Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition eLife inhibition plasticity amygdala somatostatin parvalbumin |
| title | Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition |
| title_full | Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition |
| title_fullStr | Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition |
| title_full_unstemmed | Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition |
| title_short | Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition |
| title_sort | cell type specific control of basolateral amygdala neuronal circuits via entorhinal cortex driven feedforward inhibition |
| topic | inhibition plasticity amygdala somatostatin parvalbumin |
| url | https://elifesciences.org/articles/50601 |
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