Bioengineered synthesis of phytochemical-adorned green silver oxide (Ag2O) nanoparticles via Mentha pulegium and Ficus carica extracts with high antioxidant, antibacterial, and antifungal activities
Abstract Silver oxide nanoparticles have various biomedical and pharmaceutical applications. However, conventional nanofabrication of Ag2O is associated with the use of toxic chemicals and organic solvents. To circumvent this hurdle, herein silver oxide quantum dots (Ag2O-QDs) were synthesized quick...
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| Format: | Article |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26021-4 |
| _version_ | 1828115148850593792 |
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| author | Maryam Shahzad Shirazi Mahdi Moridi Farimani Alireza Foroumadi Kamal Ghanemi Maurizio Benaglia Pooyan Makvandi |
| author_facet | Maryam Shahzad Shirazi Mahdi Moridi Farimani Alireza Foroumadi Kamal Ghanemi Maurizio Benaglia Pooyan Makvandi |
| author_sort | Maryam Shahzad Shirazi |
| collection | DOAJ |
| description | Abstract Silver oxide nanoparticles have various biomedical and pharmaceutical applications. However, conventional nanofabrication of Ag2O is associated with the use of toxic chemicals and organic solvents. To circumvent this hurdle, herein silver oxide quantum dots (Ag2O-QDs) were synthesized quickly (3 min) via the use of ultrasonic irradiation and plant-extract. Additionally, due to ultrasonic irradiation's effect on cell-wall destruction and augmentation of extraction efficiency, ultrasonic was also used in the preparation of Mentha pulegium and Ficus carica extracts (10 min, r.t) as natural eco-friendly reducing/capping agents. The UV–Vis result indicated a broad absorption peak at 400–500 nm. TEM/SEM analysis showed that ultrasound introduced a uniform spherical particle and significantly reduced particle size compared to the conventional heating method (∼ 9 nm vs. ∼ 100 nm). Silver and oxygen elements were found in the bio-synthesized Ag2O by EDS. The FTIR and phenol/flavonoid tests revealed the presence of phenol and flavonoid associated with the nanoparticles. Moreover, nanoparticles exhibited antioxidant/antibacterial/antifungal activities. The MIC and MBC results showed the Ag2O QDs synthesized with M. pulegium extract have the highest antibacterial activity against E. coli (MBC = MIC:15.6 ppm), which were significantly different from uncoated nanoparticles (MBC = MIC:500 ppm). The data reflects the role of phyto-synthesized Ag2O-QDs using ultrasonic-irradiation to develop versatile and green biomedical products. |
| first_indexed | 2024-04-11T12:36:20Z |
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| id | doaj.art-19383725f410463a97951bdbebdff137 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T12:36:20Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-19383725f410463a97951bdbebdff1372022-12-22T04:23:36ZengNature PortfolioScientific Reports2045-23222022-12-0112111510.1038/s41598-022-26021-4Bioengineered synthesis of phytochemical-adorned green silver oxide (Ag2O) nanoparticles via Mentha pulegium and Ficus carica extracts with high antioxidant, antibacterial, and antifungal activitiesMaryam Shahzad Shirazi0Mahdi Moridi Farimani1Alireza Foroumadi2Kamal Ghanemi3Maurizio Benaglia4Pooyan Makvandi5Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti UniversityDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti UniversityDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical SciencesDepartment of Marine Chemistry, Faculty of Marine Science, Khorramshahr University of Marine Science and TechnologyDipartimento di Chimica, Università degli Studi di MilanoCentre for Materials Interfaces, Istituto Italiano di TecnologiaAbstract Silver oxide nanoparticles have various biomedical and pharmaceutical applications. However, conventional nanofabrication of Ag2O is associated with the use of toxic chemicals and organic solvents. To circumvent this hurdle, herein silver oxide quantum dots (Ag2O-QDs) were synthesized quickly (3 min) via the use of ultrasonic irradiation and plant-extract. Additionally, due to ultrasonic irradiation's effect on cell-wall destruction and augmentation of extraction efficiency, ultrasonic was also used in the preparation of Mentha pulegium and Ficus carica extracts (10 min, r.t) as natural eco-friendly reducing/capping agents. The UV–Vis result indicated a broad absorption peak at 400–500 nm. TEM/SEM analysis showed that ultrasound introduced a uniform spherical particle and significantly reduced particle size compared to the conventional heating method (∼ 9 nm vs. ∼ 100 nm). Silver and oxygen elements were found in the bio-synthesized Ag2O by EDS. The FTIR and phenol/flavonoid tests revealed the presence of phenol and flavonoid associated with the nanoparticles. Moreover, nanoparticles exhibited antioxidant/antibacterial/antifungal activities. The MIC and MBC results showed the Ag2O QDs synthesized with M. pulegium extract have the highest antibacterial activity against E. coli (MBC = MIC:15.6 ppm), which were significantly different from uncoated nanoparticles (MBC = MIC:500 ppm). The data reflects the role of phyto-synthesized Ag2O-QDs using ultrasonic-irradiation to develop versatile and green biomedical products.https://doi.org/10.1038/s41598-022-26021-4 |
| spellingShingle | Maryam Shahzad Shirazi Mahdi Moridi Farimani Alireza Foroumadi Kamal Ghanemi Maurizio Benaglia Pooyan Makvandi Bioengineered synthesis of phytochemical-adorned green silver oxide (Ag2O) nanoparticles via Mentha pulegium and Ficus carica extracts with high antioxidant, antibacterial, and antifungal activities Scientific Reports |
| title | Bioengineered synthesis of phytochemical-adorned green silver oxide (Ag2O) nanoparticles via Mentha pulegium and Ficus carica extracts with high antioxidant, antibacterial, and antifungal activities |
| title_full | Bioengineered synthesis of phytochemical-adorned green silver oxide (Ag2O) nanoparticles via Mentha pulegium and Ficus carica extracts with high antioxidant, antibacterial, and antifungal activities |
| title_fullStr | Bioengineered synthesis of phytochemical-adorned green silver oxide (Ag2O) nanoparticles via Mentha pulegium and Ficus carica extracts with high antioxidant, antibacterial, and antifungal activities |
| title_full_unstemmed | Bioengineered synthesis of phytochemical-adorned green silver oxide (Ag2O) nanoparticles via Mentha pulegium and Ficus carica extracts with high antioxidant, antibacterial, and antifungal activities |
| title_short | Bioengineered synthesis of phytochemical-adorned green silver oxide (Ag2O) nanoparticles via Mentha pulegium and Ficus carica extracts with high antioxidant, antibacterial, and antifungal activities |
| title_sort | bioengineered synthesis of phytochemical adorned green silver oxide ag2o nanoparticles via mentha pulegium and ficus carica extracts with high antioxidant antibacterial and antifungal activities |
| url | https://doi.org/10.1038/s41598-022-26021-4 |
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