A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease
Sleep has an important role for long-term memory consolidation. As deficits in learning and memory are clinical characteristics of Alzheimer’s disease (AD), it has been suggested that disruptions in sleep-mediated consolidation processes are related to AD. Indeed, sleep disruptions and sleep disorde...
| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Elsevier
2023-12-01
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| coleção: | Biomarkers in Neuropsychiatry |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2666144623000084 |
| _version_ | 1827583676106407936 |
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| author | Jana Harenbrock Heinz Holling Graham Reid Ivan Koychev |
| author_facet | Jana Harenbrock Heinz Holling Graham Reid Ivan Koychev |
| author_sort | Jana Harenbrock |
| collection | DOAJ |
| description | Sleep has an important role for long-term memory consolidation. As deficits in learning and memory are clinical characteristics of Alzheimer’s disease (AD), it has been suggested that disruptions in sleep-mediated consolidation processes are related to AD. Indeed, sleep disruptions and sleep disorders are often comorbid with AD and perhaps precede the onset of AD symptoms as a risk factor. Additionally, research has shown that sleep disruptions and disorders are associated with accumulation of β-amyloid (AB), a neuropathologic hallmark and biomarker of AD. However, the studies that have investigated the relationship between sleep disturbances and AB burden have been heterogenous in design and quality, leaving it unclear whether the overall effect is statistically significant. As such, this paper investigated the relationship between sleep disturbances and AB burden by meta-analytically integrating reported correlations that have been published to date. Results revealed that higher levels of cerebral AB (lower AB42/40 ratios) were related to shorter sleep durations, highlighting the importance of total sleep time in supporting the clearance of AB during slow-wave sleep. Herein we also controlled for heterogeneity in the included studies by conducting several moderator analyses, showing an important role for age, sex, cognitive impairment, sleep disorders, and education in influencing the associations between sleep disturbances and AB. |
| first_indexed | 2024-03-08T23:10:07Z |
| format | Article |
| id | doaj.art-1939127f0b5842cbab415be934e8b869 |
| institution | Directory Open Access Journal |
| issn | 2666-1446 |
| language | English |
| last_indexed | 2024-03-08T23:10:07Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomarkers in Neuropsychiatry |
| spelling | doaj.art-1939127f0b5842cbab415be934e8b8692023-12-15T07:25:58ZengElsevierBiomarkers in Neuropsychiatry2666-14462023-12-019100068A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s diseaseJana Harenbrock0Heinz Holling1Graham Reid2Ivan Koychev3Institute of Psychology, University of Münster, Münster, GermanyInstitute of Psychology, University of Münster, Münster, GermanyDepartment of Psychiatry, University of Oxford, Oxford, UKDepartment of Psychiatry, University of Oxford, Oxford, UK; Corresponding author.Sleep has an important role for long-term memory consolidation. As deficits in learning and memory are clinical characteristics of Alzheimer’s disease (AD), it has been suggested that disruptions in sleep-mediated consolidation processes are related to AD. Indeed, sleep disruptions and sleep disorders are often comorbid with AD and perhaps precede the onset of AD symptoms as a risk factor. Additionally, research has shown that sleep disruptions and disorders are associated with accumulation of β-amyloid (AB), a neuropathologic hallmark and biomarker of AD. However, the studies that have investigated the relationship between sleep disturbances and AB burden have been heterogenous in design and quality, leaving it unclear whether the overall effect is statistically significant. As such, this paper investigated the relationship between sleep disturbances and AB burden by meta-analytically integrating reported correlations that have been published to date. Results revealed that higher levels of cerebral AB (lower AB42/40 ratios) were related to shorter sleep durations, highlighting the importance of total sleep time in supporting the clearance of AB during slow-wave sleep. Herein we also controlled for heterogeneity in the included studies by conducting several moderator analyses, showing an important role for age, sex, cognitive impairment, sleep disorders, and education in influencing the associations between sleep disturbances and AB.http://www.sciencedirect.com/science/article/pii/S2666144623000084Beta AmyloidSleepAlzheimer’s diseaseMeta-analysis |
| spellingShingle | Jana Harenbrock Heinz Holling Graham Reid Ivan Koychev A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease Biomarkers in Neuropsychiatry Beta Amyloid Sleep Alzheimer’s disease Meta-analysis |
| title | A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease |
| title_full | A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease |
| title_fullStr | A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease |
| title_full_unstemmed | A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease |
| title_short | A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease |
| title_sort | meta analysis of the relationship between sleep and β amyloid biomarkers in alzheimer s disease |
| topic | Beta Amyloid Sleep Alzheimer’s disease Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2666144623000084 |
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