Inverse relationship between 25 hydroxy Vitamin D and parathormone: Are there two inflection points?
Context: There is no consensus about the inflection point for 25 hydroxy vitamin D below which the intact PTH level increases. Objective: Determine the relationship/inflection point between 25 hydroxy vitamin D and parathormone levels. Materials and Methods: We performed a population-based analysis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2019;volume=23;issue=4;spage=422;epage=427;aulast=Mukhopadhyay |
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| author | Pradip Mukhopadhyay Sujoy Ghosh Kingshuk Bhattacharjee Subhankar Chowdhury |
| author_facet | Pradip Mukhopadhyay Sujoy Ghosh Kingshuk Bhattacharjee Subhankar Chowdhury |
| author_sort | Pradip Mukhopadhyay |
| collection | DOAJ |
| description | Context: There is no consensus about the inflection point for 25 hydroxy vitamin D below which the intact PTH level increases. Objective: Determine the relationship/inflection point between 25 hydroxy vitamin D and parathormone levels. Materials and Methods: We performed a population-based analysis on a nonobese cohort (n = 405). Results: Prevalence of vitamin D deficiency was 58.76% (n = 228). Vitamin D insufficiency was found in 34.56% (n = 140). An inverse relationship between 25 hydroxy vitamin D (25(OH)D) and intact PTH exist, but strength of such relationship is weak (r = −0.16, P = 0.018). With respect to the 25(OH)D cut-off of 16 ng/mL by IOM (EAR linked), proportion of persons with high intact PTH was higher in the group with lower 25(OH)D compared with higher 25(OH)D group (P = 0.005) and it was similar for RDA linked cut-off of 20 ng/mL also (P = 0.017). LOWESS method revealed two inflection points at which PTH levels change. A less conspicuous inflection point was found at 32 ng/mL (95% CI, 27–36), which reasonably corroborates with the current cutoff of definition of vitamin D sufficiency, and the second, steeper inflection point was found at 16.5 ng/ml (95% CI, 14.9–18.8) which corroborates with the IOM supported EAR linked value of 25(OH)D level in general population and possible definition of vitamin D deficiency. Conclusions: There are possibly two inflection points at which PTH levels change in relation to 25(OH)D levels |
| first_indexed | 2024-12-20T12:35:36Z |
| format | Article |
| id | doaj.art-193d737dd44648798840405d5d68d5fd |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-20T12:35:36Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-193d737dd44648798840405d5d68d5fd2022-12-21T19:40:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102019-01-0123442242710.4103/ijem.IJEM_322_19Inverse relationship between 25 hydroxy Vitamin D and parathormone: Are there two inflection points?Pradip MukhopadhyaySujoy GhoshKingshuk BhattacharjeeSubhankar ChowdhuryContext: There is no consensus about the inflection point for 25 hydroxy vitamin D below which the intact PTH level increases. Objective: Determine the relationship/inflection point between 25 hydroxy vitamin D and parathormone levels. Materials and Methods: We performed a population-based analysis on a nonobese cohort (n = 405). Results: Prevalence of vitamin D deficiency was 58.76% (n = 228). Vitamin D insufficiency was found in 34.56% (n = 140). An inverse relationship between 25 hydroxy vitamin D (25(OH)D) and intact PTH exist, but strength of such relationship is weak (r = −0.16, P = 0.018). With respect to the 25(OH)D cut-off of 16 ng/mL by IOM (EAR linked), proportion of persons with high intact PTH was higher in the group with lower 25(OH)D compared with higher 25(OH)D group (P = 0.005) and it was similar for RDA linked cut-off of 20 ng/mL also (P = 0.017). LOWESS method revealed two inflection points at which PTH levels change. A less conspicuous inflection point was found at 32 ng/mL (95% CI, 27–36), which reasonably corroborates with the current cutoff of definition of vitamin D sufficiency, and the second, steeper inflection point was found at 16.5 ng/ml (95% CI, 14.9–18.8) which corroborates with the IOM supported EAR linked value of 25(OH)D level in general population and possible definition of vitamin D deficiency. Conclusions: There are possibly two inflection points at which PTH levels change in relation to 25(OH)D levelshttp://www.ijem.in/article.asp?issn=2230-8210;year=2019;volume=23;issue=4;spage=422;epage=427;aulast=MukhopadhyayInflection pointvitamin D deficiencyvitamin D insufficiency |
| spellingShingle | Pradip Mukhopadhyay Sujoy Ghosh Kingshuk Bhattacharjee Subhankar Chowdhury Inverse relationship between 25 hydroxy Vitamin D and parathormone: Are there two inflection points? Indian Journal of Endocrinology and Metabolism Inflection point vitamin D deficiency vitamin D insufficiency |
| title | Inverse relationship between 25 hydroxy Vitamin D and parathormone: Are there two inflection points? |
| title_full | Inverse relationship between 25 hydroxy Vitamin D and parathormone: Are there two inflection points? |
| title_fullStr | Inverse relationship between 25 hydroxy Vitamin D and parathormone: Are there two inflection points? |
| title_full_unstemmed | Inverse relationship between 25 hydroxy Vitamin D and parathormone: Are there two inflection points? |
| title_short | Inverse relationship between 25 hydroxy Vitamin D and parathormone: Are there two inflection points? |
| title_sort | inverse relationship between 25 hydroxy vitamin d and parathormone are there two inflection points |
| topic | Inflection point vitamin D deficiency vitamin D insufficiency |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2019;volume=23;issue=4;spage=422;epage=427;aulast=Mukhopadhyay |
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