Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru
Abstract Background There is little data on the association between the lower nutrition represented by serum albumin levels and related factors in a general population. The present study aimed to determine whether the albumin level positioned as some kind of biomarker with frailty measures, trace el...
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| Format: | Article |
| Language: | English |
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Komiyama Printing Co. Ltd
2021-02-01
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| Series: | Environmental Health and Preventive Medicine |
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| Online Access: | https://doi.org/10.1186/s12199-021-00946-0 |
| _version_ | 1828358929699045376 |
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| author | Maki Yamamoto Hisashi Adachi Mika Enomoto Ako Fukami Sachiko Nakamura Yume Nohara Akiko Sakaue Nagisa Morikawa Hitoshi Hamamura Kenta Toyomasu Yoshihiro Fukumoto |
| author_facet | Maki Yamamoto Hisashi Adachi Mika Enomoto Ako Fukami Sachiko Nakamura Yume Nohara Akiko Sakaue Nagisa Morikawa Hitoshi Hamamura Kenta Toyomasu Yoshihiro Fukumoto |
| author_sort | Maki Yamamoto |
| collection | DOAJ |
| description | Abstract Background There is little data on the association between the lower nutrition represented by serum albumin levels and related factors in a general population. The present study aimed to determine whether the albumin level positioned as some kind of biomarker with frailty measures, trace elements, and an inflammation marker. Methods In 2018, we performed an epidemiological survey in 1368 subjects who resided in Tanushimaru, Japan, in which we examined the blood chemistry including albumin, trace elements, hormone levels, and carotid ultrasonography. Albumin levels were categorized into 4 groups (G1 [3.2–3.9 mg/dL], G2 [4.0–4.3 mg/dL], G3 [4.4–4.6 mg/dL], and G4 [4.7–5.3 mg/dL]). The participants underwent measurements of handgrip strength and were tested by asking to walk 5 m. Their cognitive functions were evaluated by the mini-mental state examination (MMSE). Results Multiple stepwise regression analysis demonstrated that albumin levels were significantly and independently associated with age (inversely), systolic blood pressures, estimated glomerular filtration rate (eGFR), MMSE score, frailty measures (handgrip strength), an inflammation marker (high-sensitivity C-reactive protein), hormones (growth hormone (inversely) and insulin-like growth factor-1), and trace elements (calcium, magnesium, iron, and zinc), with a linear trend. Conclusions Lower albumin levels, even in the normal range, were found to be related factors of frailty measures, trace elements, and an inflammation marker in a general population. |
| first_indexed | 2024-04-14T03:35:23Z |
| format | Article |
| id | doaj.art-193f45230dde43fd9f9fa085fa5f9526 |
| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-04-14T03:35:23Z |
| publishDate | 2021-02-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-193f45230dde43fd9f9fa085fa5f95262022-12-22T02:14:47ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152021-02-012611810.1186/s12199-021-00946-0Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in TanushimaruMaki Yamamoto0Hisashi Adachi1Mika Enomoto2Ako Fukami3Sachiko Nakamura4Yume Nohara5Akiko Sakaue6Nagisa Morikawa7Hitoshi Hamamura8Kenta Toyomasu9Yoshihiro Fukumoto10Division of Cardio-Vascular Medicine, Kurume University School of MedicineDepartment of Community Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineDivision of Cardio-Vascular Medicine, Kurume University School of MedicineAbstract Background There is little data on the association between the lower nutrition represented by serum albumin levels and related factors in a general population. The present study aimed to determine whether the albumin level positioned as some kind of biomarker with frailty measures, trace elements, and an inflammation marker. Methods In 2018, we performed an epidemiological survey in 1368 subjects who resided in Tanushimaru, Japan, in which we examined the blood chemistry including albumin, trace elements, hormone levels, and carotid ultrasonography. Albumin levels were categorized into 4 groups (G1 [3.2–3.9 mg/dL], G2 [4.0–4.3 mg/dL], G3 [4.4–4.6 mg/dL], and G4 [4.7–5.3 mg/dL]). The participants underwent measurements of handgrip strength and were tested by asking to walk 5 m. Their cognitive functions were evaluated by the mini-mental state examination (MMSE). Results Multiple stepwise regression analysis demonstrated that albumin levels were significantly and independently associated with age (inversely), systolic blood pressures, estimated glomerular filtration rate (eGFR), MMSE score, frailty measures (handgrip strength), an inflammation marker (high-sensitivity C-reactive protein), hormones (growth hormone (inversely) and insulin-like growth factor-1), and trace elements (calcium, magnesium, iron, and zinc), with a linear trend. Conclusions Lower albumin levels, even in the normal range, were found to be related factors of frailty measures, trace elements, and an inflammation marker in a general population.https://doi.org/10.1186/s12199-021-00946-0AlbuminFrailty measuresCognitive functionTrace elementsEpidemiology |
| spellingShingle | Maki Yamamoto Hisashi Adachi Mika Enomoto Ako Fukami Sachiko Nakamura Yume Nohara Akiko Sakaue Nagisa Morikawa Hitoshi Hamamura Kenta Toyomasu Yoshihiro Fukumoto Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru Environmental Health and Preventive Medicine Albumin Frailty measures Cognitive function Trace elements Epidemiology |
| title | Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru |
| title_full | Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru |
| title_fullStr | Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru |
| title_full_unstemmed | Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru |
| title_short | Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru |
| title_sort | lower albumin levels are associated with frailty measures trace elements and an inflammation marker in a cross sectional study in tanushimaru |
| topic | Albumin Frailty measures Cognitive function Trace elements Epidemiology |
| url | https://doi.org/10.1186/s12199-021-00946-0 |
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