Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice

Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice

Parkinson's disease (PD) is characterized by dopaminergic (DAergic) neuronal loss in the substantia nigra pars compacta (SNpc), resulting from α-synuclein (αSyn) toxicity. We previously reported that αSyn oligomerization and toxicity are regulated by the fatty-acid binding protein 3 (FABP3), an...

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Bibliographic Details
Main Authors: Haoyang Wang, Kohji Fukunaga, An Cheng, Yifei Wang, Nariko Arimura, Hiroshi Yoshino, Takuya Sasaki, Ichiro Kawahata
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Pharmacological Sciences
Subjects:
HY-11-9
Fatty acid-binding protein 3
α-Synuclein
Dopaminergic neuron
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000051

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