Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis
Abstract Tuberculosis (TB) diagnosis still remains to be a challenge with the currently used immune based diagnostic methods particularly Interferon Gamma Release Assay due to the sensitivity issues and their inability in differentiating stages of TB infection. Immune markers are valuable sources fo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34530-z |
| _version_ | 1827952708713185280 |
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| author | Pavithra Sampath Anuradha Rajamanickam Kannan Thiruvengadam Alangudi Palaniappan Natarajan Syed Hissar Madhavan Dhanapal Bharathiraja Thangavelu Lavanya Jayabal Paranchi Murugesan Ramesh Uma Devi Ranganathan Subash Babu Ramalingam Bethunaickan |
| author_facet | Pavithra Sampath Anuradha Rajamanickam Kannan Thiruvengadam Alangudi Palaniappan Natarajan Syed Hissar Madhavan Dhanapal Bharathiraja Thangavelu Lavanya Jayabal Paranchi Murugesan Ramesh Uma Devi Ranganathan Subash Babu Ramalingam Bethunaickan |
| author_sort | Pavithra Sampath |
| collection | DOAJ |
| description | Abstract Tuberculosis (TB) diagnosis still remains to be a challenge with the currently used immune based diagnostic methods particularly Interferon Gamma Release Assay due to the sensitivity issues and their inability in differentiating stages of TB infection. Immune markers are valuable sources for understanding disease biology and are easily accessible. Chemokines, the stimulant, and the shaper of host immune responses are the vital hub for disease mediated dysregulation and their varied levels in TB disease are considered as an important marker to define the disease status. Hence, we wanted to examine the levels of chemokines among the individuals with drug-resistant, drug-sensitive, and latent TB compared to healthy individuals. Our results demonstrated that the differential levels of chemokines between the study groups and revealed that CXCL10 and CXCL9 as potential markers of drug-resistant and drug-sensitive TB with better stage discriminating abilities. |
| first_indexed | 2024-04-09T14:01:52Z |
| format | Article |
| id | doaj.art-19418f51dbdc47359f41e17a2ce89773 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T14:01:52Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-19418f51dbdc47359f41e17a2ce897732023-05-07T11:13:05ZengNature PortfolioScientific Reports2045-23222023-05-011311910.1038/s41598-023-34530-zPlasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosisPavithra Sampath0Anuradha Rajamanickam1Kannan Thiruvengadam2Alangudi Palaniappan Natarajan3Syed Hissar4Madhavan Dhanapal5Bharathiraja Thangavelu6Lavanya Jayabal7Paranchi Murugesan Ramesh8Uma Devi Ranganathan9Subash Babu10Ramalingam Bethunaickan11Department of Immunology, ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)ICMR-NIRT-NIH-International Center for Excellence in ResearchDepartment of Statistics, ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)Department of Immunology, ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)Department of Clinical Pharmacology, ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)Greater Corporation of ChennaiGovernment Hospital for Thoracic Medicine (GHTM)Department of Immunology, ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)ICMR-NIRT-NIH-International Center for Excellence in ResearchDepartment of Immunology, ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)Abstract Tuberculosis (TB) diagnosis still remains to be a challenge with the currently used immune based diagnostic methods particularly Interferon Gamma Release Assay due to the sensitivity issues and their inability in differentiating stages of TB infection. Immune markers are valuable sources for understanding disease biology and are easily accessible. Chemokines, the stimulant, and the shaper of host immune responses are the vital hub for disease mediated dysregulation and their varied levels in TB disease are considered as an important marker to define the disease status. Hence, we wanted to examine the levels of chemokines among the individuals with drug-resistant, drug-sensitive, and latent TB compared to healthy individuals. Our results demonstrated that the differential levels of chemokines between the study groups and revealed that CXCL10 and CXCL9 as potential markers of drug-resistant and drug-sensitive TB with better stage discriminating abilities.https://doi.org/10.1038/s41598-023-34530-z |
| spellingShingle | Pavithra Sampath Anuradha Rajamanickam Kannan Thiruvengadam Alangudi Palaniappan Natarajan Syed Hissar Madhavan Dhanapal Bharathiraja Thangavelu Lavanya Jayabal Paranchi Murugesan Ramesh Uma Devi Ranganathan Subash Babu Ramalingam Bethunaickan Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis Scientific Reports |
| title | Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis |
| title_full | Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis |
| title_fullStr | Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis |
| title_full_unstemmed | Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis |
| title_short | Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis |
| title_sort | plasma chemokines cxcl10 and cxcl9 as potential diagnostic markers of drug sensitive and drug resistant tuberculosis |
| url | https://doi.org/10.1038/s41598-023-34530-z |
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