Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.

Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.

Terminal deoxynucleotidyltransferase (TdT), which template-independently synthesizes DNA during V(D)J recombination in lymphoid cells, is ubiquitylated by a BPOZ-2/Cul3 complex, as the ubiquitin ligase, and then degraded by the 26 S proteasome. We show here that TdT is ubiquitylated by the Cul3-base...

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Bibliographic Details
Main Authors: So Maezawa, Rie Fukushima, Toyofumi Matsushita, Tomoyoshi Kato, Yoshiki Takagaki, Yoshihiro Nishiyama, Sachiko Ando, Takuro Matsumoto, Kousuke Kouda, Takahide Hayano, Masahiro Suzuki, Kotaro Koiwai, Osamu Koiwai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3394778?pdf=render

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