Biomarkers of Uremic Cardiotoxicity
Cardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV risk, and among them are markers of inflammation, oxidative st...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/9/639 |
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| author | Bojan Stopic Sandra Dragicevic Branislava Medic-Brkic Aleksandra Nikolic Marko Stojanovic Sreten Budisavljevic Nada Dimkovic |
| author_facet | Bojan Stopic Sandra Dragicevic Branislava Medic-Brkic Aleksandra Nikolic Marko Stojanovic Sreten Budisavljevic Nada Dimkovic |
| author_sort | Bojan Stopic |
| collection | DOAJ |
| description | Cardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV risk, and among them are markers of inflammation, oxidative stress, acute renal injury, and microRNAs. The study analyzed biomarkers in non-dialysis-dependent (NDD; stage 3a–4 CKD) and dialysis-dependent (DD) CKD patients. The prospective cohort study included 87 patients who were followed for 18 months, during which period newly occurred CV events were recorded. Cox regression analysis confirmed serum albumin, urea, interventricular septum thickness diameter (IVST), the use of calcium antagonist, and erythropoiesis-stimulating agent to be significant predictors of CV outcome. No significant difference was observed in biomarkers of inflammation, oxidative stress, acute kidney injury (IL-18, CRP, ferritin, IMA, SOD, NGAL, and KIM-1), and miR-133a, in regards to the presence/absence of CV event, CV death, and left ventricular hypertrophy. Serum albumin, urea, IVST, and the use of calcium antagonist and erythropoiesis-stimulating agents were confirmed to be factors associated with CV events in CKD patients. Apart from traditional risk factors, new research is needed to define novel and reliable biomarkers of cardiotoxicity in CKD patients. |
| first_indexed | 2024-03-10T07:09:20Z |
| format | Article |
| id | doaj.art-1942feb6698441288f93ec551096edad |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T07:09:20Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-1942feb6698441288f93ec551096edad2023-11-22T15:31:20ZengMDPI AGToxins2072-66512021-09-0113963910.3390/toxins13090639Biomarkers of Uremic CardiotoxicityBojan Stopic0Sandra Dragicevic1Branislava Medic-Brkic2Aleksandra Nikolic3Marko Stojanovic4Sreten Budisavljevic5Nada Dimkovic6Clinical Department for Nephrology, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, SerbiaDepartment of Pharmacology, Faculty of Medicine, University of Belgrade, Clinical Pharmacology and Toxicology, dr Subotica 1, 11000 Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, SerbiaDepartment of Pharmacology, Faculty of Medicine, University of Belgrade, Clinical Pharmacology and Toxicology, dr Subotica 1, 11000 Belgrade, SerbiaClinical Department for Cardiovascular Diseases, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, SerbiaClinical Department for Nephrology, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, SerbiaCardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV risk, and among them are markers of inflammation, oxidative stress, acute renal injury, and microRNAs. The study analyzed biomarkers in non-dialysis-dependent (NDD; stage 3a–4 CKD) and dialysis-dependent (DD) CKD patients. The prospective cohort study included 87 patients who were followed for 18 months, during which period newly occurred CV events were recorded. Cox regression analysis confirmed serum albumin, urea, interventricular septum thickness diameter (IVST), the use of calcium antagonist, and erythropoiesis-stimulating agent to be significant predictors of CV outcome. No significant difference was observed in biomarkers of inflammation, oxidative stress, acute kidney injury (IL-18, CRP, ferritin, IMA, SOD, NGAL, and KIM-1), and miR-133a, in regards to the presence/absence of CV event, CV death, and left ventricular hypertrophy. Serum albumin, urea, IVST, and the use of calcium antagonist and erythropoiesis-stimulating agents were confirmed to be factors associated with CV events in CKD patients. Apart from traditional risk factors, new research is needed to define novel and reliable biomarkers of cardiotoxicity in CKD patients.https://www.mdpi.com/2072-6651/13/9/639cardiovascular eventbiomarkersinflammationoxidative stressacute renal injurymicroRNAs |
| spellingShingle | Bojan Stopic Sandra Dragicevic Branislava Medic-Brkic Aleksandra Nikolic Marko Stojanovic Sreten Budisavljevic Nada Dimkovic Biomarkers of Uremic Cardiotoxicity Toxins cardiovascular event biomarkers inflammation oxidative stress acute renal injury microRNAs |
| title | Biomarkers of Uremic Cardiotoxicity |
| title_full | Biomarkers of Uremic Cardiotoxicity |
| title_fullStr | Biomarkers of Uremic Cardiotoxicity |
| title_full_unstemmed | Biomarkers of Uremic Cardiotoxicity |
| title_short | Biomarkers of Uremic Cardiotoxicity |
| title_sort | biomarkers of uremic cardiotoxicity |
| topic | cardiovascular event biomarkers inflammation oxidative stress acute renal injury microRNAs |
| url | https://www.mdpi.com/2072-6651/13/9/639 |
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