Docosahexaenoic Acid Suppresses Silica-Induced Inflammasome Activation and IL-1 Cytokine Release by Interfering With Priming Signal

Docosahexaenoic Acid Suppresses Silica-Induced Inflammasome Activation and IL-1 Cytokine Release by Interfering With Priming Signal

Occupational exposure to respirable crystalline silica (cSiO2) has been etiologically linked to human autoimmunity. Intranasal instillation with cSiO2 triggers profuse inflammation in the lung and onset of autoimmunity in lupus-prone mice; however, dietary supplementation with the omega-3 polyunsatu...

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Bibliographic Details
Main Authors: Kathryn A. Wierenga, Josephine Wee, Kristen N. Gilley, Lichchavi D. Rajasinghe, Melissa A. Bates, Mikhail A. Gavrilin, Andrij Holian, James J. Pestka
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
macrophage
cell death
inflammasome
silica
omega-3 fatty acids
in vitro
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02130/full

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