Therapeutic Applications of the CRISPR-Cas System
The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/9/9/477 |
| _version_ | 1827663302029737984 |
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| author | Kyungmin Kang Youngjae Song Inho Kim Tae-Jung Kim |
| author_facet | Kyungmin Kang Youngjae Song Inho Kim Tae-Jung Kim |
| author_sort | Kyungmin Kang |
| collection | DOAJ |
| description | The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis and treatment, and its potential is unbounded as new methods are developed. The review focused on medical applications and discussed the most recent treatment trends and limitations, with an emphasis on CRISPR-based therapeutics for infectious disease, oncology, and genetic disease, as well as CRISPR-based diagnostics, screening, immunotherapy, and cell therapy. Given its promising results, the successful implementation of the CRISPR-Cas system in clinical practice will require further investigation into its therapeutic applications. |
| first_indexed | 2024-03-10T00:41:51Z |
| format | Article |
| id | doaj.art-194521d5fafe4fe795c267596c3df955 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T00:41:51Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-194521d5fafe4fe795c267596c3df9552023-11-23T15:06:14ZengMDPI AGBioengineering2306-53542022-09-019947710.3390/bioengineering9090477Therapeutic Applications of the CRISPR-Cas SystemKyungmin Kang0Youngjae Song1Inho Kim2Tae-Jung Kim3College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, KoreaCollege of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, KoreaCollege of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, KoreaDepartment of Hospital Pathology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul 07345, KoreaThe clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis and treatment, and its potential is unbounded as new methods are developed. The review focused on medical applications and discussed the most recent treatment trends and limitations, with an emphasis on CRISPR-based therapeutics for infectious disease, oncology, and genetic disease, as well as CRISPR-based diagnostics, screening, immunotherapy, and cell therapy. Given its promising results, the successful implementation of the CRISPR-Cas system in clinical practice will require further investigation into its therapeutic applications.https://www.mdpi.com/2306-5354/9/9/477CRISPR-Cas9Cas13Immunotherapygene editingcell therapy |
| spellingShingle | Kyungmin Kang Youngjae Song Inho Kim Tae-Jung Kim Therapeutic Applications of the CRISPR-Cas System Bioengineering CRISPR-Cas9 Cas13 Immunotherapy gene editing cell therapy |
| title | Therapeutic Applications of the CRISPR-Cas System |
| title_full | Therapeutic Applications of the CRISPR-Cas System |
| title_fullStr | Therapeutic Applications of the CRISPR-Cas System |
| title_full_unstemmed | Therapeutic Applications of the CRISPR-Cas System |
| title_short | Therapeutic Applications of the CRISPR-Cas System |
| title_sort | therapeutic applications of the crispr cas system |
| topic | CRISPR-Cas9 Cas13 Immunotherapy gene editing cell therapy |
| url | https://www.mdpi.com/2306-5354/9/9/477 |
| work_keys_str_mv | AT kyungminkang therapeuticapplicationsofthecrisprcassystem AT youngjaesong therapeuticapplicationsofthecrisprcassystem AT inhokim therapeuticapplicationsofthecrisprcassystem AT taejungkim therapeuticapplicationsofthecrisprcassystem |