In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma
Alveolar macrophages represent a cell type that is physiologic to the lung immune landscape, however, it is not known whether they play an active role to maintain the tumour immune microenvironment. Here authors show by single cell RNA sequencing and functional experiments, that intra-tumour alveola...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35701-8 |
| _version_ | 1797945787868512256 |
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| author | Seiji Taniguchi Takahiro Matsui Kenji Kimura Soichiro Funaki Yu Miyamoto Yutaka Uchida Takao Sudo Junichi Kikuta Tetsuya Hara Daisuke Motooka Yu-Chen Liu Daisuke Okuzaki Eiichi Morii Noriaki Emoto Yasushi Shintani Masaru Ishii |
| author_facet | Seiji Taniguchi Takahiro Matsui Kenji Kimura Soichiro Funaki Yu Miyamoto Yutaka Uchida Takao Sudo Junichi Kikuta Tetsuya Hara Daisuke Motooka Yu-Chen Liu Daisuke Okuzaki Eiichi Morii Noriaki Emoto Yasushi Shintani Masaru Ishii |
| author_sort | Seiji Taniguchi |
| collection | DOAJ |
| description | Alveolar macrophages represent a cell type that is physiologic to the lung immune landscape, however, it is not known whether they play an active role to maintain the tumour immune microenvironment. Here authors show by single cell RNA sequencing and functional experiments, that intra-tumour alveolar macrophages are phenotypically and transcriptionally different from the healthy ones, and likely play an aetio-pathologic role in tumorigenesis. |
| first_indexed | 2024-04-10T21:00:40Z |
| format | Article |
| id | doaj.art-19459ea4c7d247db999cc121c40ea53a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T21:00:40Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-19459ea4c7d247db999cc121c40ea53a2023-01-22T12:18:33ZengNature PortfolioNature Communications2041-17232023-01-0114111410.1038/s41467-022-35701-8In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinomaSeiji Taniguchi0Takahiro Matsui1Kenji Kimura2Soichiro Funaki3Yu Miyamoto4Yutaka Uchida5Takao Sudo6Junichi Kikuta7Tetsuya Hara8Daisuke Motooka9Yu-Chen Liu10Daisuke Okuzaki11Eiichi Morii12Noriaki Emoto13Yasushi Shintani14Masaru Ishii15Department of Immunology and Cell Biology, Osaka University Graduate School of MedicineDepartment of Immunology and Cell Biology, Osaka University Graduate School of MedicineDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of Immunology and Cell Biology, Osaka University Graduate School of MedicineDepartment of Immunology and Cell Biology, Osaka University Graduate School of MedicineDepartment of Immunology and Cell Biology, Osaka University Graduate School of MedicineDepartment of Immunology and Cell Biology, Osaka University Graduate School of MedicineLaboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical UniversityGenome Information Research Center, Research Institute for Microbial Diseases, Osaka UniversityLaboratory of Human Immunology (Single Cell Genomics), WPI-Immunology Frontier Research Center, Osaka UniversityGenome Information Research Center, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Pathology, Osaka University Graduate School of MedicineLaboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical UniversityDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of Immunology and Cell Biology, Osaka University Graduate School of MedicineAlveolar macrophages represent a cell type that is physiologic to the lung immune landscape, however, it is not known whether they play an active role to maintain the tumour immune microenvironment. Here authors show by single cell RNA sequencing and functional experiments, that intra-tumour alveolar macrophages are phenotypically and transcriptionally different from the healthy ones, and likely play an aetio-pathologic role in tumorigenesis.https://doi.org/10.1038/s41467-022-35701-8 |
| spellingShingle | Seiji Taniguchi Takahiro Matsui Kenji Kimura Soichiro Funaki Yu Miyamoto Yutaka Uchida Takao Sudo Junichi Kikuta Tetsuya Hara Daisuke Motooka Yu-Chen Liu Daisuke Okuzaki Eiichi Morii Noriaki Emoto Yasushi Shintani Masaru Ishii In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma Nature Communications |
| title | In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma |
| title_full | In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma |
| title_fullStr | In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma |
| title_full_unstemmed | In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma |
| title_short | In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma |
| title_sort | in vivo induction of activin a producing alveolar macrophages supports the progression of lung cell carcinoma |
| url | https://doi.org/10.1038/s41467-022-35701-8 |
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