Pharmacokinetic and Metabolism Studies of 12-Riboside-Pseudoginsengenin DQ by UPLC-MS/MS and UPLC-QTOF-MSE

Pharmacokinetic and Metabolism Studies of 12-Riboside-Pseudoginsengenin DQ by UPLC-MS/MS and UPLC-QTOF-MSE

Pharmacokinetic and metabolism studies of 12-riboside-pseudoginsengenin DQ (RPDQ), a novel ginsenoside with an anti-cancer effect, were carried out, aiming at discussing the characteristics of the ginsenoside with glycosylation site at C-12. In the pharmacokinetic analysis, we developed and validate...

Full description

Bibliographic Details
Main Authors:	Zhenzhou Wang, Hongqiang Lin, Hailin Zhu, Na Yang, Baisong Zhou, Cuizhu Wang, Pingya Li, Jinping Liu
Format:	Article
Language:	English
Published:	MDPI AG 2018-09-01
Series:	Molecules
Subjects:	12-riboside-pseudoginsengenin DQ pharmacokinetics metabolism UPLC-MS
Online Access:	http://www.mdpi.com/1420-3049/23/10/2499

Similar Items

Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice
by: Zeng Qi, et al.
Published: (2018-11-01)

Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1α-GLUT1 pathway
by: Sanchun Wang, et al.
Published: (2021-07-01)

UPLC-QTOF/MS-Based Nontargeted Metabolomic Analysis of Mountain- and Garden-Cultivated Ginseng of Different Ages in Northeast China
by: Hailin Zhu, et al.
Published: (2018-12-01)

Comparative Analysis of Chemical Constituents in Different Parts of Lotus by UPLC and QToF-MS
by: Haotian Pei, et al.
Published: (2021-03-01)

Metabolite Profiling of 14 Wuyi Rock Tea Cultivars Using UPLC-QTOF MS and UPLC-QqQ MS Combined with Chemometrics
by: Si Chen, et al.
Published: (2018-01-01)

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD<sup>+</sup> by Generating Dihydronicotinamide Riboside
by: Eleonora Ciarlo, et al.
Published: (2022-07-01)

Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis
by: Yaru Wang, et al.
Published: (2018-06-01)

Untargeted metabolomics profiles delineate metabolic alterations in mouse plasma during lung carcinoma development using UPLC-QTOF/MS in MSE mode
by: Huan Wu, et al.
Published: (2018-01-01)

Structural Characterization of Chemical Compounds Based on Their Fragmentation Rules in Sophorae Fructus by UPLC-QTOF-MS/MS
by: Zi-Hui He, et al.
Published: (2022-09-01)

Comprehensive Profiling and Quantification of Ginsenosides in the Root, Stem, Leaf, and Berry of Panax ginseng by UPLC-QTOF/MS
by: Jae Won Lee, et al.
Published: (2017-12-01)

Characterization of novel stress degradation products of Bempedoic acid and Ezetimibe using UPLC–MS/MS: development and validation of stability-indicating UPLC method
by: Anuradha Vejendla, et al.
Published: (2021-12-01)

UPLC-QTOF-MS Based Comparison of Rotundic Acid Metabolic Profiles in Normal and NAFLD Rats
by: Lvying Wu, et al.
Published: (2022-12-01)

UPLC–QTOF/MS tentative identification of phytochemicals from Vernonia amygdalina Delile acetone and ethanol leaf extracts
by: Christeldah Mkhonto, et al.
Published: (2023-06-01)

UPLC-QTOF/MSE and Bioassay Are Available Approaches for Identifying Quality Fluctuation of Xueshuantong Lyophilized Powder in Clinic
by: Zhi-Rui Yang, et al.
Published: (2018-06-01)

Quality Evaluation of Tricholoma matsutake Based on the Nucleic Acid Compounds by UPLC-TOF/MS and UPLC-QqQ/MS
by: Ying Xue, et al.
Published: (2018-12-01)

Comparison of the Metabolomics of Different <i>Dendrobium</i> Species by UPLC-QTOF-MS
by: Tingting Zhang, et al.
Published: (2023-12-01)

Diagnostic biomarker panels of osteoarthritis: UPLC-QToF/MS-based serum metabolic profiling
by: Xinxin Lin, et al.
Published: (2023-01-01)

UPLC-QTOF/MS-Based Metabolomics Applied for the Quality Evaluation of Four Processed Panax ginseng Products
by: Jae Won Lee, et al.
Published: (2018-08-01)

Identification of α-glucosidase inhibitors from Mulberry using UF-UPLC-QTOF-MS/MS and molecular docking
by: Adalaiti Abudurexiti, et al.
Published: (2023-02-01)

Determination of Aflatoxins in Grains by QuEChERS-UPLC-MS/MS
by: WU Qin-yan, et al.
Published: (2024-03-01)

Chemical characterization and metabolic profiling of Xiao-Er-An-Shen Decoction by UPLC-QTOF/MS
by: Ruipei Yang, et al.
Published: (2023-11-01)

Characterization of Saponins from Various Parts of <i>Platycodon grandiflorum</i> Using UPLC-QToF/MS
by: So-Jeong Lee, et al.
Published: (2021-12-01)

Analysis of metabolic differences in maize in different growth stages under nitrogen stress based on UPLC-QTOF-MS
by: Guipei Song, et al.
Published: (2023-04-01)

UPLC-QTOF-MS-based lipidomic study of wedelolactone in acute colitis mice induced by dextran sulfate sodium
by: Yuanyuan Gou, et al.
Published: (2023-09-01)

Qualitative dataset on UPLC-QTOF/MS tentative identification of phytochemicals from bioactive extract of Ipomoea mauritiana Jacq.
by: Istiak Alam, et al.
Published: (2021-04-01)

Chemical Comparison of Two Drying Methods of Mountain Cultivated Ginseng by UPLC-QTOF-MS/MS and Multivariate Statistical Analysis
by: Xin-fang Xu, et al.
Published: (2017-04-01)

Validation of UPLC-MS/MS Method for Determination of Urinary Lactulose/Mannitol
by: Jacopo Gervasoni, et al.
Published: (2018-10-01)

Profiling Phenolic Composition in Pomegranate Peel From Nine Selected Cultivars Using UHPLC-QTOF-MS and UPLC-QQQ-MS
by: Guowei Man, et al.
Published: (2022-01-01)

Metabolomic approach for discrimination of processed ginseng genus (Panax ginseng and Panax quinquefolius) using UPLC-QTOF MS
by: Hee-Won Park, et al.
Published: (2014-01-01)

Development and Validation of a Uplc-Qtof-Ms Method for Blood Analysis of Isomeric Amphetamine-Related Drugs
by: Ahmad Alamir, et al.
Published: (2022-10-01)

UPLC-QToF-ESI-MS identification and anthelmintic activity of Mitragyna inermis (Willd.) Kuntze (Rubiaceae)
by: Placide Mahougnan Toklo, et al.
Published: (2023-06-01)

Phytochemical Screening of Quaking Aspen (Populus tremuloides) Extracts by UPLC-QTOF-MS and Evaluation of their Antimicrobial Activity
by: Annabelle St-Pierre, et al.
Published: (2018-07-01)

Identification and Antioxidant Capacity of Free and Bound Phenolics in Six Varieties of Mulberry Seeds Using UPLC-ESI-QTOF-MS/MS
by: Huaqi Gao, et al.
Published: (2022-09-01)

Residue Depletion of Imidocarb in Bovine Tissues by UPLC-MS/MS
by: Yaoxin Tang, et al.
Published: (2022-12-01)

Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS
by: Ming Li, et al.
Published: (2022-07-01)

Comparative study on chemical components of Gannan navel orange in different maturity stages based on UPLC-QTOF-MS metabolomics
by: Jinxue Hou, et al.
Published: (2023-12-01)

Identification and Determination of Seven Phenolic Acids in Brazilian Green Propolis by UPLC-ESI-QTOF-MS and HPLC
by: Shengwei Sun, et al.
Published: (2019-05-01)

SPE–UPLC–MS/MS for Determination of 36 Monomers of Alkylphenol Ethoxylates in Tea
by: Qin Lin, et al.
Published: (2023-04-01)

Determination of oleandrin and adynerin in rat plasma by UPLC–MS/MS and their pharmacokinetic study
by: Meiling Zhang, et al.
Published: (2022-12-01)

Multi-Residue Analysis of Pesticide Residues in Crude Pollens by UPLC-MS/MS
by: Zhou Tong, et al.
Published: (2016-12-01)