Seasonality of coronavirus shedding in tropical bats
Anticipating cross-species transmission of zoonotic diseases requires an understanding of pathogen infection dynamics within natural reservoir hosts. Although bats might be a source of coronaviruses (CoVs) for humans, the drivers of infection dynamics in bat populations have received limited attenti...
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| Format: | Article |
| Language: | English |
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The Royal Society
2022-02-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.211600 |
| _version_ | 1797837619097239552 |
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| author | Léa Joffrin Axel O. G. Hoarau Erwan Lagadec Olalla Torrontegi Marie Köster Gildas Le Minter Muriel Dietrich Patrick Mavingui Camille Lebarbenchon |
| author_facet | Léa Joffrin Axel O. G. Hoarau Erwan Lagadec Olalla Torrontegi Marie Köster Gildas Le Minter Muriel Dietrich Patrick Mavingui Camille Lebarbenchon |
| author_sort | Léa Joffrin |
| collection | DOAJ |
| description | Anticipating cross-species transmission of zoonotic diseases requires an understanding of pathogen infection dynamics within natural reservoir hosts. Although bats might be a source of coronaviruses (CoVs) for humans, the drivers of infection dynamics in bat populations have received limited attention. We conducted a fine-scale 2-year longitudinal study of CoV infection dynamics in the largest colony of Reunion free-tailed bats (Mormopterus francoismoutoui), a tropical insectivorous species. Real-time PCR screening of 1080 fresh individual faeces samples collected during the two consecutive years revealed an extreme variation of the detection rate of bats shedding viruses over the birthing season (from 0% to 80%). Shedding pulses were repeatedly observed and occurred both during late pregnancy and within two months after parturition. An additional shedding pulse at the end of the second year suggests some inter-annual variations. We also detected viral RNA in bat guano up to three months after bats had left the cave. Our results highlight the importance of fine-scale longitudinal studies to capture the rapid change of bat CoV infection over months, and that CoV shedding pulses in bats may increase spillover risk. |
| first_indexed | 2024-04-09T15:27:37Z |
| format | Article |
| id | doaj.art-1947d02df9da4406b59d7ee3d0b9b898 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-04-09T15:27:37Z |
| publishDate | 2022-02-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-1947d02df9da4406b59d7ee3d0b9b8982023-04-28T11:04:40ZengThe Royal SocietyRoyal Society Open Science2054-57032022-02-019210.1098/rsos.211600Seasonality of coronavirus shedding in tropical batsLéa Joffrin0Axel O. G. Hoarau1Erwan Lagadec2Olalla Torrontegi3Marie Köster4Gildas Le Minter5Muriel Dietrich6Patrick Mavingui7Camille Lebarbenchon8Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceUniversité de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceUniversité de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceUniversité de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceUniversité de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceUniversité de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceUniversité de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceUniversité de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceUniversité de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, GIP CYROI, 2 rue Maxime Rivière, Saint Denis, La Réunion, FranceAnticipating cross-species transmission of zoonotic diseases requires an understanding of pathogen infection dynamics within natural reservoir hosts. Although bats might be a source of coronaviruses (CoVs) for humans, the drivers of infection dynamics in bat populations have received limited attention. We conducted a fine-scale 2-year longitudinal study of CoV infection dynamics in the largest colony of Reunion free-tailed bats (Mormopterus francoismoutoui), a tropical insectivorous species. Real-time PCR screening of 1080 fresh individual faeces samples collected during the two consecutive years revealed an extreme variation of the detection rate of bats shedding viruses over the birthing season (from 0% to 80%). Shedding pulses were repeatedly observed and occurred both during late pregnancy and within two months after parturition. An additional shedding pulse at the end of the second year suggests some inter-annual variations. We also detected viral RNA in bat guano up to three months after bats had left the cave. Our results highlight the importance of fine-scale longitudinal studies to capture the rapid change of bat CoV infection over months, and that CoV shedding pulses in bats may increase spillover risk.https://royalsocietypublishing.org/doi/10.1098/rsos.211600alpha-coronavirusdisease ecologylongitudinal studyIndian OceanMolossidaeReunion Island |
| spellingShingle | Léa Joffrin Axel O. G. Hoarau Erwan Lagadec Olalla Torrontegi Marie Köster Gildas Le Minter Muriel Dietrich Patrick Mavingui Camille Lebarbenchon Seasonality of coronavirus shedding in tropical bats Royal Society Open Science alpha-coronavirus disease ecology longitudinal study Indian Ocean Molossidae Reunion Island |
| title | Seasonality of coronavirus shedding in tropical bats |
| title_full | Seasonality of coronavirus shedding in tropical bats |
| title_fullStr | Seasonality of coronavirus shedding in tropical bats |
| title_full_unstemmed | Seasonality of coronavirus shedding in tropical bats |
| title_short | Seasonality of coronavirus shedding in tropical bats |
| title_sort | seasonality of coronavirus shedding in tropical bats |
| topic | alpha-coronavirus disease ecology longitudinal study Indian Ocean Molossidae Reunion Island |
| url | https://royalsocietypublishing.org/doi/10.1098/rsos.211600 |
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