Comparison of Radionuclide Impurities Activated during Irradiation of <sup>18</sup>O-Enriched Water in Tantalum and Silver Targets during the Production of <sup>18</sup>F in a Cyclotron
During the production of <sup>18</sup>F, as a result of the interaction of the beam of protons and secondary neutrons with the structural elements of the target body, many radionuclide impurities are created in the cyclotron. As part of this work, we theoretically predicted which isotope...
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3485 |
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| author | Teresa Jakubowska Magdalena Długosz-Lisiecka Michał Biegała |
| author_facet | Teresa Jakubowska Magdalena Długosz-Lisiecka Michał Biegała |
| author_sort | Teresa Jakubowska |
| collection | DOAJ |
| description | During the production of <sup>18</sup>F, as a result of the interaction of the beam of protons and secondary neutrons with the structural elements of the target body, many radionuclide impurities are created in the cyclotron. As part of this work, we theoretically predicted which isotopes would be activated in the target tantalum or silver bodies. Subsequently, we used gamma spectrometry analysis to verify these predictions. The results were compared with the work of other authors who studied titanium and niobium as materials for making the target body. Tantalum has been evaluated as the most favorable in terms of generating radionuclide impurities during the production of <sup>18</sup>F by irradiation of <sup>18</sup>O-enriched water in accelerated proton cyclotrons. Only three radionuclides were identified in the tested samples: <sup>181</sup>W, <sup>181</sup>Hf, and <sup>182</sup>Ta with a half-life of fewer than 120 days. The remaining reactions led to the formation of stable isotopes. |
| first_indexed | 2024-03-11T04:41:11Z |
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| id | doaj.art-1949975d444c4c28987c5b9d103eaa29 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:41:11Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1949975d444c4c28987c5b9d103eaa292023-11-17T20:39:39ZengMDPI AGMolecules1420-30492023-04-01288348510.3390/molecules28083485Comparison of Radionuclide Impurities Activated during Irradiation of <sup>18</sup>O-Enriched Water in Tantalum and Silver Targets during the Production of <sup>18</sup>F in a CyclotronTeresa Jakubowska0Magdalena Długosz-Lisiecka1Michał Biegała2Institute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, Wróblewskiego 15, 90-924 Łódź, PolandInstitute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, Wróblewskiego 15, 90-924 Łódź, PolandDepartment of Medical Physics, Copernicus Memorial Hospital in Lodz Comprehensive Cancer Center and Traumatology, Pabianicka 62, 93-513 Łódź, PolandDuring the production of <sup>18</sup>F, as a result of the interaction of the beam of protons and secondary neutrons with the structural elements of the target body, many radionuclide impurities are created in the cyclotron. As part of this work, we theoretically predicted which isotopes would be activated in the target tantalum or silver bodies. Subsequently, we used gamma spectrometry analysis to verify these predictions. The results were compared with the work of other authors who studied titanium and niobium as materials for making the target body. Tantalum has been evaluated as the most favorable in terms of generating radionuclide impurities during the production of <sup>18</sup>F by irradiation of <sup>18</sup>O-enriched water in accelerated proton cyclotrons. Only three radionuclides were identified in the tested samples: <sup>181</sup>W, <sup>181</sup>Hf, and <sup>182</sup>Ta with a half-life of fewer than 120 days. The remaining reactions led to the formation of stable isotopes.https://www.mdpi.com/1420-3049/28/8/3485tantalum target bodysilver target bodycyclotrongamma spectrometryactivation productFDG |
| spellingShingle | Teresa Jakubowska Magdalena Długosz-Lisiecka Michał Biegała Comparison of Radionuclide Impurities Activated during Irradiation of <sup>18</sup>O-Enriched Water in Tantalum and Silver Targets during the Production of <sup>18</sup>F in a Cyclotron Molecules tantalum target body silver target body cyclotron gamma spectrometry activation product FDG |
| title | Comparison of Radionuclide Impurities Activated during Irradiation of <sup>18</sup>O-Enriched Water in Tantalum and Silver Targets during the Production of <sup>18</sup>F in a Cyclotron |
| title_full | Comparison of Radionuclide Impurities Activated during Irradiation of <sup>18</sup>O-Enriched Water in Tantalum and Silver Targets during the Production of <sup>18</sup>F in a Cyclotron |
| title_fullStr | Comparison of Radionuclide Impurities Activated during Irradiation of <sup>18</sup>O-Enriched Water in Tantalum and Silver Targets during the Production of <sup>18</sup>F in a Cyclotron |
| title_full_unstemmed | Comparison of Radionuclide Impurities Activated during Irradiation of <sup>18</sup>O-Enriched Water in Tantalum and Silver Targets during the Production of <sup>18</sup>F in a Cyclotron |
| title_short | Comparison of Radionuclide Impurities Activated during Irradiation of <sup>18</sup>O-Enriched Water in Tantalum and Silver Targets during the Production of <sup>18</sup>F in a Cyclotron |
| title_sort | comparison of radionuclide impurities activated during irradiation of sup 18 sup o enriched water in tantalum and silver targets during the production of sup 18 sup f in a cyclotron |
| topic | tantalum target body silver target body cyclotron gamma spectrometry activation product FDG |
| url | https://www.mdpi.com/1420-3049/28/8/3485 |
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