Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice.

Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice.

Isoniazid (INH) and Rifampicin (RFP) are widely used in the world for the treatment of tuberculosis, but the hepatotoxicity is a major concern during clinical therapy. Previous studies showed that these drugs induced oxidative stress in liver, and several antioxidants abated this effect. Metallothio...

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Bibliographic Details
Main Authors: Yong Lian, Jing Zhao, Peiyu Xu, Yimei Wang, Jun Zhao, Li Jia, Ze Fu, Li Jing, Gang Liu, Shuangqing Peng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3742471?pdf=render

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