FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity
Hypertriglyceridemia (HTG) has been associated with an increased risk of pancreatitis and cardiovascular disease. Adipose tissue plays a major role in lipid metabolism, mobilization and distribution. We have compared the histological and transcriptomic profiles of the subcutaneous (SAT) and visceral...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/3/1013 |
| _version_ | 1797624031800721408 |
|---|---|
| author | Óscar Osorio-Conles Ainitze Ibarzabal José María Balibrea Josep Vidal Emilio Ortega Ana de Hollanda |
| author_facet | Óscar Osorio-Conles Ainitze Ibarzabal José María Balibrea Josep Vidal Emilio Ortega Ana de Hollanda |
| author_sort | Óscar Osorio-Conles |
| collection | DOAJ |
| description | Hypertriglyceridemia (HTG) has been associated with an increased risk of pancreatitis and cardiovascular disease. Adipose tissue plays a major role in lipid metabolism, mobilization and distribution. We have compared the histological and transcriptomic profiles of the subcutaneous (SAT) and visceral (VAT) adipose tissues from subjects with severe obesity undergoing bariatric surgery with (Ob-HTG, <i>n</i> = 37) and without HTG (Ob-NTG, <i>n</i> = 67). Mean age and BMI were 51.87 ± 11.21 years, 45.78 ± 6.96 kg/m<sup>2</sup> and 50.03 ± 10.17 years, 44.04 ± 4.69 kg/m<sup>2</sup>, respectively. The Ob-HTG group showed higher levels of glycosylated hemoglobin, fasting plasma glucose, high-sensitivity C-reactive protein and prevalence of hypertension. The degree of fibrosis was increased by 14% in SAT from the Ob-HTG group (<i>p</i> = 0.028), while adipocyte size distribution was comparable. Twenty genes were found differentially expressed in SAT and VAT between study groups. Among them, only SAT expression of FABP4 resulted significantly associated with circulating triglyceride levels after adjusting for other covariates and independently explained 5% of the variance in triglyceride levels in the combined model. This relationship was not found in the cohort of lean or overweight patients with normotriglyceridemia (non-Ob, <i>n</i> = 21). These results emphasize the contribution of SAT to triglyceride concentrations in obesity and indicate that FABP4 may be a potential drug target for the treatment of HTG. |
| first_indexed | 2024-03-11T09:37:08Z |
| format | Article |
| id | doaj.art-194ac69132fb4f908c3c922d9f9cca73 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:37:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-194ac69132fb4f908c3c922d9f9cca732023-11-16T17:10:25ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-01123101310.3390/jcm12031013FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in ObesityÓscar Osorio-Conles0Ainitze Ibarzabal1José María Balibrea2Josep Vidal3Emilio Ortega4Ana de Hollanda5Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Monforte de Lemos Ave. 3–5, 28029 Madrid, SpainGastrointestinal Surgery Department, Hospital Clínic de Barcelona, Villarroel Street 170, 08036 Barcelona, SpainGastrointestinal Surgery Department, Hospital Clínic de Barcelona, Villarroel Street 170, 08036 Barcelona, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Monforte de Lemos Ave. 3–5, 28029 Madrid, SpainObesity Unit, Endocrinology and Nutrition Department, Hospital Clínic de Barcelona, Villarroel Street 170, 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló Street 149, 08036 Barcelona, SpainHypertriglyceridemia (HTG) has been associated with an increased risk of pancreatitis and cardiovascular disease. Adipose tissue plays a major role in lipid metabolism, mobilization and distribution. We have compared the histological and transcriptomic profiles of the subcutaneous (SAT) and visceral (VAT) adipose tissues from subjects with severe obesity undergoing bariatric surgery with (Ob-HTG, <i>n</i> = 37) and without HTG (Ob-NTG, <i>n</i> = 67). Mean age and BMI were 51.87 ± 11.21 years, 45.78 ± 6.96 kg/m<sup>2</sup> and 50.03 ± 10.17 years, 44.04 ± 4.69 kg/m<sup>2</sup>, respectively. The Ob-HTG group showed higher levels of glycosylated hemoglobin, fasting plasma glucose, high-sensitivity C-reactive protein and prevalence of hypertension. The degree of fibrosis was increased by 14% in SAT from the Ob-HTG group (<i>p</i> = 0.028), while adipocyte size distribution was comparable. Twenty genes were found differentially expressed in SAT and VAT between study groups. Among them, only SAT expression of FABP4 resulted significantly associated with circulating triglyceride levels after adjusting for other covariates and independently explained 5% of the variance in triglyceride levels in the combined model. This relationship was not found in the cohort of lean or overweight patients with normotriglyceridemia (non-Ob, <i>n</i> = 21). These results emphasize the contribution of SAT to triglyceride concentrations in obesity and indicate that FABP4 may be a potential drug target for the treatment of HTG.https://www.mdpi.com/2077-0383/12/3/1013adipose tissuetriglyceridesobesitytranscriptionFABP4subcutaneous adipose tissue |
| spellingShingle | Óscar Osorio-Conles Ainitze Ibarzabal José María Balibrea Josep Vidal Emilio Ortega Ana de Hollanda FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity Journal of Clinical Medicine adipose tissue triglycerides obesity transcription FABP4 subcutaneous adipose tissue |
| title | FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity |
| title_full | FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity |
| title_fullStr | FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity |
| title_full_unstemmed | FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity |
| title_short | FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity |
| title_sort | fabp4 expression in subcutaneous adipose tissue is independently associated with circulating triglycerides in obesity |
| topic | adipose tissue triglycerides obesity transcription FABP4 subcutaneous adipose tissue |
| url | https://www.mdpi.com/2077-0383/12/3/1013 |
| work_keys_str_mv | AT oscarosorioconles fabp4expressioninsubcutaneousadiposetissueisindependentlyassociatedwithcirculatingtriglyceridesinobesity AT ainitzeibarzabal fabp4expressioninsubcutaneousadiposetissueisindependentlyassociatedwithcirculatingtriglyceridesinobesity AT josemariabalibrea fabp4expressioninsubcutaneousadiposetissueisindependentlyassociatedwithcirculatingtriglyceridesinobesity AT josepvidal fabp4expressioninsubcutaneousadiposetissueisindependentlyassociatedwithcirculatingtriglyceridesinobesity AT emilioortega fabp4expressioninsubcutaneousadiposetissueisindependentlyassociatedwithcirculatingtriglyceridesinobesity AT anadehollanda fabp4expressioninsubcutaneousadiposetissueisindependentlyassociatedwithcirculatingtriglyceridesinobesity |