Plasma Oxidized Albumin in Acute Ischemic Stroke Is Associated With Better Outcomes
Introduction: Plasma oxidized human serum albumin (OxHSA) is evidence of an active antioxidant mechanism as measured by oxidized species of HSA. CXCL-10 is a pro-inflammatory chemokine associated with ischemic conditions. Accordingly, we examined the relationship of admission OxHSA and CXCL-10 with...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-07-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00709/full |
| _version_ | 1828770252691865600 |
|---|---|
| author | Leonard T. Rael Jan Leonard Kristin Salottolo Raphael Bar-Or Russell E. Bartt Jeffrey C. Wagner David Bar-Or |
| author_facet | Leonard T. Rael Jan Leonard Kristin Salottolo Raphael Bar-Or Russell E. Bartt Jeffrey C. Wagner David Bar-Or |
| author_sort | Leonard T. Rael |
| collection | DOAJ |
| description | Introduction: Plasma oxidized human serum albumin (OxHSA) is evidence of an active antioxidant mechanism as measured by oxidized species of HSA. CXCL-10 is a pro-inflammatory chemokine associated with ischemic conditions. Accordingly, we examined the relationship of admission OxHSA and CXCL-10 with discharge mRS in acute ischemic stroke (AIS).Methods: Plasma samples and clinical data were collected prospectively at a Comprehensive Stroke Center. Admission biomarkers of oxidative stress, CXCL-10 and %OxHSA, were measured. We examined if CXCL-10 or %OxHSA correlated with age, admission NIHSS score, and discharge mRS score using Spearman's Rank correlation. Logistic regression was performed to identify independent predictors of a favorable discharge mRS (≤2).Results: In 106 consecutive AIS patients, the median age was 73 (IQR 61–84), 47% were male, and the median admission NIHSS score was 11 (IQR 5–19). %OxHSA and CXCL-10 were significantly correlated (r = 0.23, p = 0.02). Both biomarkers were significantly correlated with age: %OxHSA (r = 0.44, p < 0.001) and CXCL-10 (r = 0.32, p = 0.001). Neither biomarker was correlated with admission NIHSS. There was a borderline significant correlation with discharge mRS and %OxHSA (r = −0.17, p = 0.08), where higher %OxHSA correlated with lower discharge mRS scores. For every 1% increase in %OxHSA, the odds of a favorable discharge mRS increased 11%. The odds of a favorable discharge mRS decreased 18% for every 1-point increase in the initial NIHSS.Conclusions: OxHSA, the result of an oxidative environment and evidence of the strong antioxidant buffering capacity of HSA, correlated with CXCL-10 and discharge mRS, implying that strong antioxidant activity of albumin may confer better outcomes. |
| first_indexed | 2024-12-11T14:03:48Z |
| format | Article |
| id | doaj.art-194e0afc34554821866ee2b9fd1dbe9d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T14:03:48Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-194e0afc34554821866ee2b9fd1dbe9d2022-12-22T01:03:45ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-07-011010.3389/fneur.2019.00709467354Plasma Oxidized Albumin in Acute Ischemic Stroke Is Associated With Better OutcomesLeonard T. RaelJan LeonardKristin SalottoloRaphael Bar-OrRussell E. BarttJeffrey C. WagnerDavid Bar-OrIntroduction: Plasma oxidized human serum albumin (OxHSA) is evidence of an active antioxidant mechanism as measured by oxidized species of HSA. CXCL-10 is a pro-inflammatory chemokine associated with ischemic conditions. Accordingly, we examined the relationship of admission OxHSA and CXCL-10 with discharge mRS in acute ischemic stroke (AIS).Methods: Plasma samples and clinical data were collected prospectively at a Comprehensive Stroke Center. Admission biomarkers of oxidative stress, CXCL-10 and %OxHSA, were measured. We examined if CXCL-10 or %OxHSA correlated with age, admission NIHSS score, and discharge mRS score using Spearman's Rank correlation. Logistic regression was performed to identify independent predictors of a favorable discharge mRS (≤2).Results: In 106 consecutive AIS patients, the median age was 73 (IQR 61–84), 47% were male, and the median admission NIHSS score was 11 (IQR 5–19). %OxHSA and CXCL-10 were significantly correlated (r = 0.23, p = 0.02). Both biomarkers were significantly correlated with age: %OxHSA (r = 0.44, p < 0.001) and CXCL-10 (r = 0.32, p = 0.001). Neither biomarker was correlated with admission NIHSS. There was a borderline significant correlation with discharge mRS and %OxHSA (r = −0.17, p = 0.08), where higher %OxHSA correlated with lower discharge mRS scores. For every 1% increase in %OxHSA, the odds of a favorable discharge mRS increased 11%. The odds of a favorable discharge mRS decreased 18% for every 1-point increase in the initial NIHSS.Conclusions: OxHSA, the result of an oxidative environment and evidence of the strong antioxidant buffering capacity of HSA, correlated with CXCL-10 and discharge mRS, implying that strong antioxidant activity of albumin may confer better outcomes.https://www.frontiersin.org/article/10.3389/fneur.2019.00709/fullischemic strokeinflammationoxidative stressproteomicsalbumin |
| spellingShingle | Leonard T. Rael Jan Leonard Kristin Salottolo Raphael Bar-Or Russell E. Bartt Jeffrey C. Wagner David Bar-Or Plasma Oxidized Albumin in Acute Ischemic Stroke Is Associated With Better Outcomes Frontiers in Neurology ischemic stroke inflammation oxidative stress proteomics albumin |
| title | Plasma Oxidized Albumin in Acute Ischemic Stroke Is Associated With Better Outcomes |
| title_full | Plasma Oxidized Albumin in Acute Ischemic Stroke Is Associated With Better Outcomes |
| title_fullStr | Plasma Oxidized Albumin in Acute Ischemic Stroke Is Associated With Better Outcomes |
| title_full_unstemmed | Plasma Oxidized Albumin in Acute Ischemic Stroke Is Associated With Better Outcomes |
| title_short | Plasma Oxidized Albumin in Acute Ischemic Stroke Is Associated With Better Outcomes |
| title_sort | plasma oxidized albumin in acute ischemic stroke is associated with better outcomes |
| topic | ischemic stroke inflammation oxidative stress proteomics albumin |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00709/full |
| work_keys_str_mv | AT leonardtrael plasmaoxidizedalbumininacuteischemicstrokeisassociatedwithbetteroutcomes AT janleonard plasmaoxidizedalbumininacuteischemicstrokeisassociatedwithbetteroutcomes AT kristinsalottolo plasmaoxidizedalbumininacuteischemicstrokeisassociatedwithbetteroutcomes AT raphaelbaror plasmaoxidizedalbumininacuteischemicstrokeisassociatedwithbetteroutcomes AT russellebartt plasmaoxidizedalbumininacuteischemicstrokeisassociatedwithbetteroutcomes AT jeffreycwagner plasmaoxidizedalbumininacuteischemicstrokeisassociatedwithbetteroutcomes AT davidbaror plasmaoxidizedalbumininacuteischemicstrokeisassociatedwithbetteroutcomes |