Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling
The development of the embryonic lung demands complex endodermal–mesodermal interactions, which are regulated by a variety of signaling proteins. Hedgehog (Hh) signaling is vital for lung development. It plays a key regulatory role during several morphogenic mechanisms, such as cell growth, differen...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/11/1774 |
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| author | Ling-Hui Zeng Muhammad Qasim Barkat Shahzada Khurram Syed Shahid Shah Ghulam Abbas Chengyun Xu Amina Mahdy Nadia Hussain Liaqat Hussain Abdul Majeed Kashif-ur-Rehman Khan Ximei Wu Musaddique Hussain |
| author_facet | Ling-Hui Zeng Muhammad Qasim Barkat Shahzada Khurram Syed Shahid Shah Ghulam Abbas Chengyun Xu Amina Mahdy Nadia Hussain Liaqat Hussain Abdul Majeed Kashif-ur-Rehman Khan Ximei Wu Musaddique Hussain |
| author_sort | Ling-Hui Zeng |
| collection | DOAJ |
| description | The development of the embryonic lung demands complex endodermal–mesodermal interactions, which are regulated by a variety of signaling proteins. Hedgehog (Hh) signaling is vital for lung development. It plays a key regulatory role during several morphogenic mechanisms, such as cell growth, differentiation, migration, and persistence of cells. On the other hand, abnormal expression or loss of regulation of Hh signaling leads to airway asthmatic remodeling, which is characterized by cellular matrix modification in the respiratory system, goblet cell hyperplasia, deposition of collagen, epithelial cell apoptosis, proliferation, and activation of fibroblasts. Hh also targets some of the pathogens and seems to have a significant function in tissue repairment and immune-related disorders. Similarly, aberrant Hh signaling expression is critically associated with the etiology of a variety of other airway lung diseases, mainly, bronchial or tissue fibrosis, lung cancer, and pulmonary arterial hypertension, suggesting that controlled regulation of Hh signaling is crucial to retain healthy lung functioning. Moreover, shreds of evidence imply that the Hh signaling pathway links to lung organogenesis and asthmatic airway remodeling. Here, we compiled all up-to-date investigations linked with the role of Hh signaling in the development of lungs as well as the attribution of Hh signaling in impairment of lung expansion, airway remodeling, and immune response. In addition, we included all current investigational and therapeutic approaches to treat airway asthmatic remodeling and immune system pathway diseases. |
| first_indexed | 2024-03-10T01:24:31Z |
| format | Article |
| id | doaj.art-194e5fdbccd64660ae2881c6ca6b5bb9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T01:24:31Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-194e5fdbccd64660ae2881c6ca6b5bb92023-11-23T13:52:33ZengMDPI AGCells2073-44092022-05-011111177410.3390/cells11111774Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway RemodelingLing-Hui Zeng0Muhammad Qasim Barkat1Shahzada Khurram Syed2Shahid Shah3Ghulam Abbas4Chengyun Xu5Amina Mahdy6Nadia Hussain7Liaqat Hussain8Abdul Majeed9Kashif-ur-Rehman Khan10Ximei Wu11Musaddique Hussain12Department of Pharmacology, Zhejiang University City College, 51 Huzhou Street, Hangzhou 310015, ChinaKey Laboratory of CFDA for Respiratory Drug Research, Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, ChinaDepartment of Basic Medical Sciences, School of Health Sciences, University of Management and Technology Lahore, Lahore 54000, PakistanFaculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, PakistanFaculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, PakistanKey Laboratory of CFDA for Respiratory Drug Research, Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, ChinaMedical Pharmacology Department, International School of Medicine, Istanbul Medipol University, Istanbul 34000, TurkeyDepartment of Pharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain 64141, United Arab EmiratesFaculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, PakistanFaculty of Pharmacy, Bahauddin Zakariya University, Mulatn 60000, PakistanFaculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, PakistanDepartment of Pharmacology, Zhejiang University City College, 51 Huzhou Street, Hangzhou 310015, ChinaFaculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, PakistanThe development of the embryonic lung demands complex endodermal–mesodermal interactions, which are regulated by a variety of signaling proteins. Hedgehog (Hh) signaling is vital for lung development. It plays a key regulatory role during several morphogenic mechanisms, such as cell growth, differentiation, migration, and persistence of cells. On the other hand, abnormal expression or loss of regulation of Hh signaling leads to airway asthmatic remodeling, which is characterized by cellular matrix modification in the respiratory system, goblet cell hyperplasia, deposition of collagen, epithelial cell apoptosis, proliferation, and activation of fibroblasts. Hh also targets some of the pathogens and seems to have a significant function in tissue repairment and immune-related disorders. Similarly, aberrant Hh signaling expression is critically associated with the etiology of a variety of other airway lung diseases, mainly, bronchial or tissue fibrosis, lung cancer, and pulmonary arterial hypertension, suggesting that controlled regulation of Hh signaling is crucial to retain healthy lung functioning. Moreover, shreds of evidence imply that the Hh signaling pathway links to lung organogenesis and asthmatic airway remodeling. Here, we compiled all up-to-date investigations linked with the role of Hh signaling in the development of lungs as well as the attribution of Hh signaling in impairment of lung expansion, airway remodeling, and immune response. In addition, we included all current investigational and therapeutic approaches to treat airway asthmatic remodeling and immune system pathway diseases.https://www.mdpi.com/2073-4409/11/11/1774hedgehog signalinglung developmentasthmatic airway remodelingtargets pathogenrepairment in tissue and immune system |
| spellingShingle | Ling-Hui Zeng Muhammad Qasim Barkat Shahzada Khurram Syed Shahid Shah Ghulam Abbas Chengyun Xu Amina Mahdy Nadia Hussain Liaqat Hussain Abdul Majeed Kashif-ur-Rehman Khan Ximei Wu Musaddique Hussain Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling Cells hedgehog signaling lung development asthmatic airway remodeling targets pathogen repairment in tissue and immune system |
| title | Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling |
| title_full | Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling |
| title_fullStr | Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling |
| title_full_unstemmed | Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling |
| title_short | Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling |
| title_sort | hedgehog signaling linking embryonic lung development and asthmatic airway remodeling |
| topic | hedgehog signaling lung development asthmatic airway remodeling targets pathogen repairment in tissue and immune system |
| url | https://www.mdpi.com/2073-4409/11/11/1774 |
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