Serological diagnosis of Chlamydia infections: proposal of a cost-effective approach
Infections caused by genus Chlamydia are challenging for phisicians, as a results of a complicated pathogenesis and a variable clinical picture. Furthermore, potential sequelae following Chlamydia trachomatis, Chlamydia pneumoniae, Chlamydia psittaci infections are of clinical relevant interest. Ser...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2008-06-01
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| Series: | Microbiologia Medica |
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| Online Access: | http://www.pagepressjournals.org/index.php/mm/article/view/2578 |
| _version_ | 1811318538792599552 |
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| author | Gino Ciarrocchi |
| author_facet | Gino Ciarrocchi |
| author_sort | Gino Ciarrocchi |
| collection | DOAJ |
| description | Infections caused by genus Chlamydia are challenging for phisicians, as a results of a complicated pathogenesis and a variable clinical picture. Furthermore, potential sequelae following Chlamydia trachomatis, Chlamydia pneumoniae, Chlamydia psittaci infections are of clinical relevant interest. Serodiagnosis is a clue tool when the direct antigen research or the bacteria fragments detection is impaired. Some serological tests such as the ELISA or the indirect micro-immunofluorescence methods are routinely performed. To improve the diagnostic efficiency of these tests, a selective coating of specie-specific reactive antigens on microwells or on microscopic slides is proposed.A highly selective coating is essential to generate a specific immune response for each Chlamydia species and high levels of distinct IgA, IgG, IgM antibody classes.The goal of serology is the diagnostic value of results, therefore the correct choice of the best screening and confirmation test is of extreme relevance due to the clinical impact of results for the therapeutical approach and management of acute and chronic infections. In conclusion, a quantitative specific anti-Chlamydia IgG and IgA antibody detection is a useful method to improve the follow up of complicated chronic clinical sequelae. |
| first_indexed | 2024-04-13T12:27:42Z |
| format | Article |
| id | doaj.art-194ec65c5efe4214ae348dcef394f37a |
| institution | Directory Open Access Journal |
| issn | 2280-6423 |
| language | English |
| last_indexed | 2024-04-13T12:27:42Z |
| publishDate | 2008-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Microbiologia Medica |
| spelling | doaj.art-194ec65c5efe4214ae348dcef394f37a2022-12-22T02:46:58ZengPAGEPress PublicationsMicrobiologia Medica2280-64232008-06-0123210.4081/mm.2008.25781831Serological diagnosis of Chlamydia infections: proposal of a cost-effective approachGino CiarrocchiInfections caused by genus Chlamydia are challenging for phisicians, as a results of a complicated pathogenesis and a variable clinical picture. Furthermore, potential sequelae following Chlamydia trachomatis, Chlamydia pneumoniae, Chlamydia psittaci infections are of clinical relevant interest. Serodiagnosis is a clue tool when the direct antigen research or the bacteria fragments detection is impaired. Some serological tests such as the ELISA or the indirect micro-immunofluorescence methods are routinely performed. To improve the diagnostic efficiency of these tests, a selective coating of specie-specific reactive antigens on microwells or on microscopic slides is proposed.A highly selective coating is essential to generate a specific immune response for each Chlamydia species and high levels of distinct IgA, IgG, IgM antibody classes.The goal of serology is the diagnostic value of results, therefore the correct choice of the best screening and confirmation test is of extreme relevance due to the clinical impact of results for the therapeutical approach and management of acute and chronic infections. In conclusion, a quantitative specific anti-Chlamydia IgG and IgA antibody detection is a useful method to improve the follow up of complicated chronic clinical sequelae.http://www.pagepressjournals.org/index.php/mm/article/view/2578Serodiagnosis, Antigens, ELISA, Sequelae |
| spellingShingle | Gino Ciarrocchi Serological diagnosis of Chlamydia infections: proposal of a cost-effective approach Microbiologia Medica Serodiagnosis, Antigens, ELISA, Sequelae |
| title | Serological diagnosis of Chlamydia infections: proposal of a cost-effective approach |
| title_full | Serological diagnosis of Chlamydia infections: proposal of a cost-effective approach |
| title_fullStr | Serological diagnosis of Chlamydia infections: proposal of a cost-effective approach |
| title_full_unstemmed | Serological diagnosis of Chlamydia infections: proposal of a cost-effective approach |
| title_short | Serological diagnosis of Chlamydia infections: proposal of a cost-effective approach |
| title_sort | serological diagnosis of chlamydia infections proposal of a cost effective approach |
| topic | Serodiagnosis, Antigens, ELISA, Sequelae |
| url | http://www.pagepressjournals.org/index.php/mm/article/view/2578 |
| work_keys_str_mv | AT ginociarrocchi serologicaldiagnosisofchlamydiainfectionsproposalofacosteffectiveapproach |